Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Levin Jeremy Ian"'
Autor:
Rebecca Cowling, Michele A. Sharr, Jerauld S. Skotnicki, Zhang Bao Xu, Venkatesan Aranapakam, Vincent Sandanayaka, G. Jin, Arie Zask, Mila Du, John W. Ellingboe, Joseph Mcdevitt, Jannie Lea Baker, Jeff Tillett, Loran M. Killar, Jamie Marie Davis, Thomas Walter, Weiguang Zhao, Amy Sung, George Theodore Grosu, John F. DiJoseph, Levin Jeremy Ian
Publikováno v:
Journal of Medicinal Chemistry. 46:2376-2396
The matrix metalloproteinases (MMPs) are a family of zinc-containing endopeptidases that play a key role in both physiological and pathological tissue degradation. In our preceding paper, we have reported on a series of novel and orally active N-hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93592dc8a1e6940279319e17ff2512ee
https://doi.org/10.1021/jm0205550
https://doi.org/10.1021/jm0205550
Publikováno v:
Drug Discovery Today. 4:10-16
Simulation of biological processes, systems and organs is a necessary complement to genetic and molecular sequencing. Using the heart as an example, the authors describe the way in which such modelling can be used in drug discovery, development and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5380f28f743db8f59a01545644918541
https://doi.org/10.1016/s1359-6446(98)01277-x
https://doi.org/10.1016/s1359-6446(98)01277-x
Autor:
Aranapakam Mudumbai Venkatesan, Amy Sung, John W. Ellingboe, Diane Joseph Mccarthy, Jerauld S. Skotnicki, Jamie Marie Davis, Jannie Lea Baker, Weixin Xu, Arie Zask, Dauphine Barone, G. Jin, John F. DiJoseph, Levin Jeremy Ian, George Theodore Grosu
Publikováno v:
Journal of medicinal chemistry. 47(25)
A series of 4-alkynyloxy phenyl sulfanyl, sulfinyl and sulfony alkyl and piperidine-4-carboxylic acid hydroxamides were synthesized. Their structure-activity relationships, against tumor necrosis factor-alpha (TACE) and matrix metalloproteinase (MMP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a83e65668311fca711e49e65601ff34
https://pubmed.ncbi.nlm.nih.gov/15566296
https://pubmed.ncbi.nlm.nih.gov/15566296