Stimulation of CGRP-expressing neurons in the medial cerebellar nucleus induces light and touch sensitivity in mice

Autor: Mengya Wang, William C. Castonguay, Thomas L. Duong, Michael W. Huebner, Harold C. Flinn, Agatha M. Greenway, Andrew F. Russo, Levi P. Sowers

Publikováno v: Neurobiology of Pain, Vol 12, Iss , Pp 100098- (2022)

Calcitonin gene-related peptide (CGRP) is considered a major player in migraine pathophysiology. However, the location and mechanisms of CGRP actions in migraine are not clearly elucidated. One important question yet to be answered is: Does central C

Externí odkaz: https://doaj.org/article/618401c65c09491bb56383ad3c7027c7

ASIC1A in the bed nucleus of the stria terminalis mediates TMT-evoked freezing

Autor: Rebecca J. Taugher, Ali eGhobbeh, Levi P. Sowers, Rong eFan, John A. Wemmie

Publikováno v: Frontiers in Neuroscience, Vol 9 (2015)

Mice display an unconditioned freezing response to TMT, a predator odor isolated from fox feces. Here we found that in addition to freezing, TMT caused mice to decrease breathing rate, perhaps because of the aversive smell. Consistent with this possi

Externí odkaz: https://doaj.org/article/93c267f87802495a8952416cc6976f47

CGRP Administration into the Cerebellum Evokes Migraine-like Behaviors Predominately in Female Mice

Autor: Mengya Wang, Thomas L. Duong, Brandon J. Rea, Jayme S. Waite, Michael W. Huebner, Harold C. Flinn, Andrew F. Russo, Levi P. Sowers

The neuropeptide calcitonin gene-related peptide (CGRP) is a major player in migraine pathophysiology. Previous preclinical studies demonstrated that intracerebroventricular administration of CGRP caused migraine-like behaviors in mice, but the sites

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de06a30a2f4024ca84999bfacf7832a2
https://doi.org/10.1101/2022.01.24.477577

Seizures are regulated by ubiquitin-specific peptidase 9 X-linked (USP9X), a de-ubiquitinase.

Autor: Lily Paemka, Vinit B Mahajan, Salleh N Ehaideb, Jessica M Skeie, Men Chee Tan, Shu Wu, Allison J Cox, Levi P Sowers, Jozef Gecz, Lachlan Jolly, Polly J Ferguson, Benjamin Darbro, Amy Schneider, Ingrid E Scheffer, Gemma L Carvill, Heather C Mefford, Hatem El-Shanti, Stephen A Wood, J Robert Manak, Alexander G Bassuk

Publikováno v: PLoS Genetics, Vol 11, Iss 3, p e1005022 (2015)

Epilepsy is a common disabling disease with complex, multifactorial genetic and environmental etiology. The small fraction of epilepsies subject to Mendelian inheritance offers key insight into epilepsy disease mechanisms; and pathologies brought on

Externí odkaz: https://doaj.org/article/c8c9d088c9034e5f95796391fbe65f07

Amylin Analog Pramlintide Induces Migraine-like Attacks in Patients

Autor: Niklas Rye Jørgensen, Levi P. Sowers, Debbie L. Hay, Tayla A Rees, Jakeb Petersen, Jayme S Waite, Simon J. O'Carroll, Hashmat Ghanizada, Andrew Siow, Mohammad Al-Mahdi Al-Karagholi, Sheryl Tan, Mette Mørch-Rasmussen, Lene Theil Skovgaard, Nanna Arngrim, Brandon J. Rea, Messoud Ashina, Margaret A. Brimble, Christopher S. Walker, Andrew F. Russo, Paul W. R. Harris

Publikováno v: Ann Neurol
Ghanizada, H, Al-Karagholi, M A-M, Walker, C S, Arngrim, N, Rees, T, Petersen, J, Siow, A, Mørch-Rasmussen, M, Tan, S, O'Carroll, S J, Harris, P, Skovgaard, L T, Jørgensen, N R, Brimble, M, Waite, J S, Rea, B J, Sowers, L P, Russo, A F, Hay, D L & Ashina, M 2021, ' Amylin analog pramlintide induces migraine-like attacks in patients ', Annals of Neurology, vol. 89, no. 6, pp. 1157-1171 . https://doi.org/10.1002/ana.26072

OBJECTIVE: Migraine is a prevalent and disabling neurological disease. Its genesis is poorly understood and there remains unmet clinical need. We aimed to identify mechanisms and thus novel therapeutic targets for migraine using human models of migra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ece78f0e61f07be4bea4a9f5802687b
https://pubmed.ncbi.nlm.nih.gov/33772845