Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Levi L Blazer"'
Autor:
Samuel C Griffiths, Jia Tan, Armin Wagner, Levi L Blazer, Jarrett J Adams, Srisathya Srinivasan, Shayan Moghisaei, Sachdev S Sidhu, Christian Siebold, Hsin-Yi Henry Ho
Publikováno v:
eLife, Vol 13 (2024)
The receptor tyrosine kinase ROR2 mediates noncanonical WNT5A signaling to orchestrate tissue morphogenetic processes, and dysfunction of the pathway causes Robinow syndrome, brachydactyly B, and metastatic diseases. The domain(s) and mechanisms requ
Externí odkaz:
https://doaj.org/article/439dab7e296646b59ddc2e91b98ed24d
A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy
Autor:
Rony Chidiac, Md. Abedin, Graham Macleod, Andy Yang, Pierre E Thibeault, Levi L Blazer, Jarrett J Adams, Lingling Zhang, Heidi Roehrich, Ha‐Neul Jo, Somasekar Seshagiri, Sachdev S Sidhu, Harald J Junge, Stephane Angers
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 7, Pp 1-16 (2021)
Abstract The FZD4:LRP5:TSPAN12 receptor complex is activated by the secreted protein Norrin in retinal endothelial cells and leads to βcatenin‐dependent formation of the blood–retina–barrier during development and its homeostasis in adults. Mu
Externí odkaz:
https://doaj.org/article/823716d920524f3b8debfe84b49df873
Autor:
Abdulkhaliq Alsaadi, Mara Artibani, Zhiyuan Hu, Nina Wietek, Matteo Morotti, Laura Santana Gonzalez, Moiad Alazzam, Jason Jiang, Beena Abdul, Hooman Soleymani majd, Levi L. Blazer, Jarret Adams, Francesca Silvestri, Sachdev S. Sidhu, Joan S. Brugge, Ahmed Ashour Ahmed
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113354- (2023)
Summary: The study of fallopian tube (FT) function in health and disease has been hampered by limited knowledge of FT stem cells and lack of in vitro models of stem cell renewal and differentiation. Using optimized organoid culture conditions to addr
Externí odkaz:
https://doaj.org/article/b3b9c8430ef84ea8bc3a229beaff06ed
Autor:
Leonie Enderle, Karim H. Shalaby, Maryna Gorelik, Alexander Weiss, Levi L. Blazer, Marcin Paduch, Lia Cardarelli, Anthony Kossiakoff, Jarrett J. Adams, Sachdev S. Sidhu
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
In order to direct T cells to specific features of solid cancer cells, we engineered a bispecific antibody format, named Dual Antigen T cell Engager (DATE), by fusing a single-chain variable fragment targeting CD3 to a tumor-targeting antigen-binding
Externí odkaz:
https://doaj.org/article/777c600eb1a04893b2cef9f6918ac3c1
Autor:
Daniel Newsted, Sunandan Banerjee, Kathleen Watt, Sarah Nersesian, Peter Truesdell, Levi L. Blazer, Lia Cardarelli, Jarrett J. Adams, Sachdev S. Sidhu, Andrew W. Craig
Publikováno v:
OncoImmunology, Vol 8, Iss 2 (2019)
Epithelial ovarian cancer (EOC) is a leading cause of cancer-related death in women. EOC is often diagnosed at late stages, with peritoneal metastases and ascites production. Current surgery and platinum-based chemotherapy regimes fail to prevent rec
Externí odkaz:
https://doaj.org/article/130a6182e3ab4d159a039e7c5d973fe5
Autor:
Shikai Hu, Silvia Liu, Yu Bian, Minakshi Poddar, Sucha Singh, Catherine Cao, Jackson McGaughey, Aaron Bell, Levi L. Blazer, Jarret J. Adams, Sachdev S. Sidhu, Stephane Angers, Satdarshan P. Monga
Publikováno v:
Cell reports. Medicine. 3(10)
The conclusive identity of Wnts regulating liver zonation (LZ) and regeneration (LR) remains unclear despite an undisputed role of β-catenin. Using single-cell analysis, we identified a conserved Wnt2 and Wnt9b expression in endothelial cells (ECs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f340593a89b5ceffdf4a3400a30b51
https://pubmed.ncbi.nlm.nih.gov/36220068
https://pubmed.ncbi.nlm.nih.gov/36220068
Autor:
Shikai Hu, Silvia Liu, Yu Bian, Minakshi Poddar, Sucha Singh, Catherine Cao, Jackson McGaughey, Aaron Bell, Levi L Blazer, Jarret J Adams, Sachdev S Sidhu, Stephane Angers, Satdarshan P. Monga
The conclusive identity of Wnt proteins regulating liver zonation (LZ) and regeneration (LR) remains unclear despite an undisputed role of β-catenin. Using single-cell analysis of liver cells from various species, a conserved Wnt2 and Wnt9b expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a9c83074becc9862865c6e20742aae
https://doi.org/10.1101/2022.03.18.484868
https://doi.org/10.1101/2022.03.18.484868
Autor:
Kannan Sankar, Kyle Trainor, Levi L. Blazer, Jarrett J. Adams, Sachdev S. Sidhu, Tyler Day, Elizabeth Meiering, Johannes K. X. Maier
Publikováno v:
Molecular informaticsReferences. 41(9)
There has been a remarkable increase in the number of biologics, especially monoclonal antibodies, in the market over the last decade. In addition to attaining the desired binding to their targets, a crucial aspect is the 'developability' of these dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff545ad6532df8e2f2e620916fd06265
https://pubmed.ncbi.nlm.nih.gov/35277930
https://pubmed.ncbi.nlm.nih.gov/35277930
Autor:
Levi L. Blazer, Jarrett Adams, Ho H-Yh., Christian Siebold, S.C. Griffiths, Justin Tan, Sachdev S. Sidhu, Armin Wagner
The receptor tyrosine kinase ROR2 mediates noncanonical WNT5A signaling to orchestrate tissue morphogenetic processes, and dysfunction of the pathway causes Robinow syndrome, Brachydactyly B and metastatic diseases. The domain(s) and mechanisms requi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa5ac55b89c91fc9fb12381f82070983
https://doi.org/10.1101/2021.07.26.453829
https://doi.org/10.1101/2021.07.26.453829
Autor:
Maryna Gorelik, Alexander Weiss, Jarrett Adams, Sachdev S. Sidhu, Anthony A. Kossiakoff, Marcin Paduch, Lia Cardarelli, Karim H. Shalaby, Leonie Enderle, Levi L. Blazer
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
In order to direct T cells to specific features of solid cancer cells, we engineered a bispecific antibody format, named Dual Antigen T cell Engager (DATE), by fusing a single-chain variable fragment targeting CD3 to a tumor-targeting antigen-binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ea767b7206bb797aeda0ca536e21aff
http://europepmc.org/articles/PMC8253144
http://europepmc.org/articles/PMC8253144