Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Levi J. McClelland"'
Autor:
Levi J. McClelland, Kaiming Zhang, Tung-Chung Mou, Jake Johnston, Cindee Yates-Hansen, Shanshan Li, Celestine J. Thomas, Tzanko I. Doukov, Sarah Triest, Alexandre Wohlkonig, Gregory G. Tall, Jan Steyaert, Wah Chiu, Stephen R. Sprang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Ric-8A is guanine nucleotide exchange factor (GEF) that also acts as a folding chaperone for its Gα subunit. Here, the authors present the structure of Ric-8A bound to nucleotide-free Gαi1, revealing the mechanism by which Ric-8A exerts both GEF an
Externí odkaz:
https://doaj.org/article/a3332f800ecb43968d52458b851393bf
Autor:
Daniel Muñoz-Reyes, Levi J McClelland, Sandra Arroyo-Urea, Sonia Sánchez-Yepes, Juan Sabín, Sara Pérez-Suárez, Margarita Menendez, Alicia Mansilla, Javier García-Nafría, Stephen Sprang, Maria Jose Sanchez-Barrena
Publikováno v:
eLife, Vol 12 (2023)
The neuronal calcium sensor 1 (NCS-1), an EF-hand Ca2+ binding protein, and Ric-8A coregulate synapse number and probability of neurotransmitter release. Recently, the structures of Ric-8A bound to Gα have revealed how Ric-8A phosphorylation promote
Externí odkaz:
https://doaj.org/article/7d5b388bf3c64418aa041a168ab18b6e
Autor:
Mike T. Rothfuss, Dustin C. Becht, Baisen Zeng, Levi J. McClelland, Cindee Yates-Hansen, Bruce E. Bowler
Publikováno v:
Biophysical Journal. 121:48a-49a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bfac8f05abbb0f5acb6ce7e5a140b12
https://doi.org/10.1016/j.bpj.2021.11.2492
https://doi.org/10.1016/j.bpj.2021.11.2492
Autor:
Sarah Triest, Jake Johnston, Alexandre Wohlkonig, Gregory G. Tall, Wah Chiu, Cindee Yates-Hansen, Levi J. McClelland, Kaiming Zhang, Shanshan Li, Stephen R. Sprang, Jan Steyaert, Tzanko Doukov, Celestine J. Thomas, Tung-Chung Mou
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications
Nature Communications
Ric-8A is a cytosolic Guanine Nucleotide exchange Factor (GEF) that activates heterotrimeric G protein alpha subunits (Gα) and serves as an essential Gα chaperone. Mechanisms by which Ric-8A catalyzes these activities, which are stimulated by Casei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffc64e78c7a7f7bbd812a3e6e0551d03
https://doi.org/10.1038/s41467-020-14943-4
https://doi.org/10.1038/s41467-020-14943-4
Autor:
Kaiming Zhang, Sarah Triest, Celestine J. Thomas, Alexandre Wohlkonig, Tung-Chung Mou, Levi J. McClelland, Stephen R. Sprang, Shanshan Li, Gregory G. Tall, Cindee Yates-Hansen, Tzanko Doukov, Jan Steyaert, Jake Johnston, Wah Chiu
Ric-8A is a cytosolic Guanine Nucleotide exchange Factor (GEF) that activates heterotrimeric G protein alpha subunits (Gα)1. Ric-8A is essential to life in multicellular eukaryotes by virtue of its chaperone activity that is required for Gα biogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4136cc8f9295e3b372a1bf7833451621
https://doi.org/10.1101/2020.01.04.893156
https://doi.org/10.1101/2020.01.04.893156
Autor:
Harmen B. Steele, Stephen R. Sprang, Tung-Chung Mou, David C. Holley, Levi J. McClelland, Bruce E. Bowler, Frank G. Whitby, J.B. Alexander Ross
Publikováno v:
Journal of the American Chemical Society. 138:16770-16778
Cytochrome c can acquire peroxidase activity when it binds to cardiolipin in mitochondrial membranes. The resulting oxygenation of cardiolipin by cytochrome c provides an early signal for the onset of apoptosis. The structure of this enzyme-substrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706fc9307b1158b8575638bf74692e77
https://doi.org/10.1021/jacs.6b10745
https://doi.org/10.1021/jacs.6b10745
Autor:
Bruce E. Bowler, Levi J. McClelland
Publikováno v:
Biochemistry. 55:2681-2693
Overall protein stability is thought to have an important impact on the millisecond time scale dynamics modulating enzyme function. In order to better understand the effects of overall stability on the substructure dynamics of mitochondrial cytochrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac58a281e9d6aaa895bb6bb8415bd14
https://doi.org/10.1021/acs.biochem.5b01060
https://doi.org/10.1021/acs.biochem.5b01060
Autor:
Jan Steyaert, Wah Chiu, Tung-Chung Mou, Jake Johnston, Kaiming Zhang, Levi J. McClelland, Cindee Yates-Hansen, Stephen R. Sprang
Publikováno v:
Biophysical Journal. 118:335a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ca34137b38b70bdae09c33700156ea0
https://doi.org/10.1016/j.bpj.2019.11.1869
https://doi.org/10.1016/j.bpj.2019.11.1869
Autor:
Sean M. Seagraves, Melisa M. Cherney, Justin E. Culbertson, Md. Khurshid Alam Khan, Swati Bandi, Bruce E. Bowler, Levi J. McClelland
Publikováno v:
JBIC Journal of Biological Inorganic Chemistry. 20:805-819
Trimethyllysine 72 (tmK72) has been suggested to play a role in sterically constraining the heme crevice dynamics of yeast iso-1-cytochrome c mediated by the Ω-loop D cooperative substructure (residues 70 to 85). A tmK72A mutation causes a gain in p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc08595a704b674854d5389a78cbe9c
https://doi.org/10.1007/s00775-015-1267-1
https://doi.org/10.1007/s00775-015-1267-1
Autor:
Bruce E. Bowler, Levi J. McClelland, Tung-Chung Mou, Margaret E. Jeakins-Cooley, Stephen R. Sprang
Publikováno v:
Proceedings of the National Academy of Sciences. 111:6648-6653
At the onset of apoptosis, the peroxidation of cardiolipin at the inner mitochondrial membrane by cytochrome c requires an open coordination site on the heme. We report a 1.45-Å resolution structure of yeast iso-1-cytochrome c with the Met80 heme li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba520aafcc0f8326aa3fa4711f01fd6
https://doi.org/10.1073/pnas.1323828111
https://doi.org/10.1073/pnas.1323828111