Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Levi Gray-Rupp"'
Autor:
Lan Chen, Beatriz Millare, Jeremy Chen, Aaron Cooper, Natalie Bezman, Angela Boroughs, Suchismita Mohanty, David DeTomaso, Amy-Jo Casbon, Thomas J Gardner, Anzhi Yao, Ashley Cass, Alma Gomez, Manching Ku, Lionel Berthoin, Meng Lim, Azalea Ong, Vince Thomas, Nicholas Quant, Brian Hsu, Levi Gray-Rupp, W Nicholas Haining
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/5e4a90e7ee90474c9a89859560f13aa5
Publikováno v:
Cancer Research. 83:LB092-LB092
Chimeric antigen receptor T (CAR T) cell therapeutics have produced curative outcomes in hematological malignancies but have yet to be developed into safe and effective therapies for solid tumors. A major obstacle to developing targeted therapies aga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da2c2ab01f6acbe73dbdbcfecfbcaba4
https://doi.org/10.1158/1538-7445.am2023-lb092
https://doi.org/10.1158/1538-7445.am2023-lb092
Autor:
Thomas J. Gardner, Adam Litterman, Brenal K. Singh, Luisa Silva, Mukund Hari, Stanley Zhou, Colin Tang, Sahil Joshi, John Gagnon, Oliver Takacsi-Nagy, Jason Hall, Hans Pope, James Zhang, Alma Gomez, Jeremy Chen, Suchismita Mohanty, Vince Thomas, Nicholas Quant, Beatriz Millare, Amy-Jo Casbon, Natalie Bezman, Levi Gray-Rupp, Angela C. Boroughs, W. Nicholas Haining
Publikováno v:
Cancer Research. 83:1768-1768
T cell exhaustion resulting from chronic antigen stimulation and immunosuppression in the tumor microenvironment (TME) limits CAR T efficacy in the solid tumor setting. We have previously shown that engineering therapeutic T cell products using CRISP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80a8865a290a8e8b7ff29611bc03bcaf
https://doi.org/10.1158/1538-7445.am2023-1768
https://doi.org/10.1158/1538-7445.am2023-1768
Autor:
Thomas J. Gardner, Beatriz Millare, Anzhi Yao, Ashley Cass, Suchismita Mohanty, Jeremy Chen, Alma Gomez, David DeTomaso, Manching Ku, Lionel Berthoin, Meng Lim, Azalea Ong, Vince Thomas, Nicholas Quant, Brian Hsu, Amy-Jo Casbon, Natalie Bezman, Aaron Cooper, Levi Gray-Rupp, Angela C. Boroughs, W. Nicholas Haining
Publikováno v:
Cancer Research. 83:4073-4073
Clinically effective adoptive T cell therapy for the treatment of solid tumors will require robust T cell expansion, persistence, and potency. The Janus-kinase signal transducer and activator of transcription (JAK-STAT) pathway governs T cell activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::413fe48f49faa365be778206d2c11e9b
https://doi.org/10.1158/1538-7445.am2023-4073
https://doi.org/10.1158/1538-7445.am2023-4073
Autor:
Angela C. Boroughs, Irene Scarfo, Nickolas Attanasio, Thomas Gardner, Jenessa B. Smith, Jennifer McDevitt, Laura Lim, Nishant Mehta, Suchismita Mohanty, James Zhang, Eric Cui, Vibhavari Sail, Amanda Fearon, Samuel Williams, Stephen Santoro, W. Nicholas Haining, Levi Gray-Rupp
Publikováno v:
Cancer Research. 83:4088-4088
Clinically effective CAR-T cell therapy for solid tumors, such as clear cell renal cell carcinoma (ccRCC), will require substantial T cell engineering to increase their specificity and potency. We have developed an Integrated Circuit T cell (ICT) tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f9b23ffee994c2ec6e119dd522aa940
https://doi.org/10.1158/1538-7445.am2023-4088
https://doi.org/10.1158/1538-7445.am2023-4088