Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Levi C.M. Buil"'
Autor:
Hyeongju Kim, Sophie Lenoir, Angela Helfricht, Taeyang Jung, Zhana K. Karneva, Yejin Lee, Wouter Beumer, Geert B. van der Horst, Herma Anthonijsz, Levi C.M. Buil, Frits van der Ham, Gerard J. Platenburg, Pasi Purhonen, Hans Hebert, Sandrine Humbert, Frédéric Saudou, Pontus Klein, Ji-Joon Song
Publikováno v:
JCI Insight, Vol 7, Iss 17 (2022)
Huntington’s disease (HD) is a late-onset neurological disorder for which therapeutics are not available. Its key pathological mechanism involves the proteolysis of polyglutamine-expanded (polyQ-expanded) mutant huntingtin (mHTT), which generates N
Externí odkaz:
https://doaj.org/article/4386a98caf404dd9a84e53f674710b00
Autor:
Mark C. de Gooijer, Nienke A. de Vries, Tessa Buckle, Levi C.M. Buil, Jos H. Beijnen, Willem Boogerd, Olaf van Tellingen
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 7, Pp 710-720 (2018)
The anticancer drug temozolomide is the only drug with proven activity against high-grade gliomas and has therefore become a part of the standard treatment of these tumors. P-glycoprotein (P-gp; ABCB1) and breast cancer resistance protein (BCRP; ABCG
Externí odkaz:
https://doaj.org/article/2cdc215f2d024dcda47d7a99dc431f6c
Autor:
Esther Hulleman, Gertjan J.L. Kaspers, Dannis G. van Vuurden, Olaf van Tellingen, Timothy N. Phoenix, Marianna Bugiani, Ángel Montero Carcaboso, Eric H. Raabe, Rintaro Hashizume, Jan Koster, Jos W.R. Twisk, Laurine E. Wedekind, Tonny Lagerweij, Levi C.M. Buil, Marjolein Breur, Piotr Waranecki, Kenn Zwaan, A. Charlotte P. Sewing, Dennis S. Metselaar, Mark C. de Gooijer, Michaël H. Meel
Purpose:Diffuse intrinsic pontine glioma (DIPG) is an incurable type of pediatric brain cancer, which in the majority of cases is driven by mutations in genes encoding histone 3 (H3K27M). We here determined the preclinical therapeutic potential of co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426e325eb37e62297bb71b9385084f22
https://doi.org/10.1158/1078-0432.c.6529571
https://doi.org/10.1158/1078-0432.c.6529571
Autor:
Olaf van Tellingen, Tom Würdinger, Jos H. Beijnen, Rolf W. Sparidans, Nishita Thota, Levi C.M. Buil, Gayathri Chandrasekaran, Diana Hanekamp, Mark C. de Gooijer, Fan Lin
File contains information on the methods used to establish murine glioma cell lines and how they have been used to assess the effects of the PI3K inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec5a997b0f813b3da2f99448140e485
https://doi.org/10.1158/1078-0432.22465941
https://doi.org/10.1158/1078-0432.22465941
Autor:
Olaf van Tellingen, Jos H. Beijnen, Thomas Würdinger, Jan H. Beumer, Susan M. Christner, Levi C.M. Buil, Eloy Moreno Roig, Mark C. de Gooijer, Fan Lin
Purpose: Little is known about the optimal clinical use of ABT-888 (veliparib) for treatment of glioblastoma. ABT-888 is a PARP inhibitor undergoing extensive clinical evaluation in glioblastoma, because it may synergize with the standard-of-care tem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0546221e8be1770b5d267a9ae3bc3f
https://doi.org/10.1158/1078-0432.c.6523136
https://doi.org/10.1158/1078-0432.c.6523136
Autor:
Esther Hulleman, Gertjan J.L. Kaspers, Dannis G. van Vuurden, Olaf van Tellingen, Marianna Bugiani, Angel Montero Carcaboso, Eric H. Raabe, Rintaro Hashizume, Jan Koster, Jos W.R. Twisk, Laurine E. Wedekind, Levi C.M. Buil, Marjolein Breur, Piotr Waranecki, Miriam Guillén Navarro, Mark C. de Gooijer, Michaël H. Meel
Purpose: Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive pediatric brain tumor, for which no effective therapeutic options currently exist. We here determined the potential of inhibition of the maternal embryonic leucine zipper kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f90191fa7f06dd7271053385b6dae3
https://doi.org/10.1158/1078-0432.c.6527250
https://doi.org/10.1158/1078-0432.c.6527250
Autor:
Esther Hulleman, Gertjan J.L. Kaspers, Dannis G. van Vuurden, Olaf van Tellingen, Marianna Bugiani, Angel Montero Carcaboso, Eric H. Raabe, Rintaro Hashizume, Jan Koster, Jos W.R. Twisk, Laurine E. Wedekind, Levi C.M. Buil, Marjolein Breur, Piotr Waranecki, Miriam Guillén Navarro, Mark C. de Gooijer, Michaël H. Meel
Supplemental legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386360746eb22880fc05f2812c32e7e9
https://doi.org/10.1158/1078-0432.22469406.v1
https://doi.org/10.1158/1078-0432.22469406.v1
Autor:
Olaf van Tellingen, Jos H. Beijnen, Thomas Würdinger, Jan H. Beumer, Susan M. Christner, Levi C.M. Buil, Eloy Moreno Roig, Mark C. de Gooijer, Fan Lin
PDF file - 112K, Fig. S1. In vitro transwell assays. Fig. S2. PAR levels by Western blot analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a22c3af25d4dcad05e05addc321e56a
https://doi.org/10.1158/1078-0432.22455845.v1
https://doi.org/10.1158/1078-0432.22455845.v1
Autor:
Olaf van Tellingen, Tom Würdinger, Jos H. Beijnen, Rolf W. Sparidans, Nishita Thota, Levi C.M. Buil, Gayathri Chandrasekaran, Diana Hanekamp, Mark C. de Gooijer, Fan Lin
File contains data on the efficacy of the PI3K inhibitors against murine glioma derived cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe8b323262281c738068f18fa64f5c9
https://doi.org/10.1158/1078-0432.22465944
https://doi.org/10.1158/1078-0432.22465944
Autor:
Esther Hulleman, Gertjan J.L. Kaspers, Dannis G. van Vuurden, Olaf van Tellingen, Marianna Bugiani, Angel Montero Carcaboso, Eric H. Raabe, Rintaro Hashizume, Jan Koster, Jos W.R. Twisk, Laurine E. Wedekind, Levi C.M. Buil, Marjolein Breur, Piotr Waranecki, Miriam Guillén Navarro, Mark C. de Gooijer, Michaël H. Meel
List of off-target effects of OTSSP167 occurring at concentrations lower than 50nM, derived from the publicly available phosphoproteomics database at http://proteomicsdb.org.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de7597b75f8200094fd246fdbfd0169
https://doi.org/10.1158/1078-0432.22469400
https://doi.org/10.1158/1078-0432.22469400