Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Levi B Wood"'
Autor:
Kanupriya R. Daga, Andrew M. Larey, Maria G. Morfin, Kailin Chen, Sara Bitarafan, Jana M. Carpenter, Hannah M. Hynds, Kelly M. Hines, Levi B. Wood, Ross A. Marklein
Publikováno v:
Journal of Biological Engineering, Vol 18, Iss 1, Pp 1-21 (2024)
Abstract Background Mesenchymal stromal cell derived extracellular vesicles (MSC-EVs) are a promising therapeutic for neuroinflammation. MSC-EVs can interact with microglia, the resident immune cells of the brain, to exert their immunomodulatory effe
Externí odkaz:
https://doaj.org/article/ed07ae149d72409faf0f21728dc5d06e
Autor:
Alyssa F. Pybus, Sara Bitarafan, Rowan O. Brothers, Alivia Rohrer, Arushi Khaitan, Felix Rivera Moctezuma, Kareena Udeshi, Brae Davies, Sydney Triplett, Martin N. Griffin, Eric B. Dammer, Srikant Rangaraju, Erin M. Buckley, Levi B. Wood
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-21 (2024)
Abstract Repetitive mild traumatic brain injuries (rmTBI) sustained within a window of vulnerability can result in long term cognitive deficits, depression, and eventual neurodegeneration associated with tau pathology, amyloid beta (Aβ) plaques, gli
Externí odkaz:
https://doaj.org/article/33fb43db821e412cb4a51344d8ea1517
Autor:
Prateek Kumar, Annie M. Goettemoeller, Claudia Espinosa-Garcia, Brendan R. Tobin, Ali Tfaily, Ruth S. Nelson, Aditya Natu, Eric B. Dammer, Juliet V. Santiago, Sneha Malepati, Lihong Cheng, Hailian Xiao, Duc D. Duong, Nicholas T. Seyfried, Levi B. Wood, Matthew J. M. Rowan, Srikant Rangaraju
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-26 (2024)
Abstract Dysfunction in fast-spiking parvalbumin interneurons (PV-INs) may represent an early pathophysiological perturbation in Alzheimer’s Disease (AD). Defining early proteomic alterations in PV-INs can provide key biological and translationally
Externí odkaz:
https://doaj.org/article/4a3d7575d66340e7b52ba0e5a848ab2b
Autor:
Waleed A Farahat, Levi B Wood, Ioannis K Zervantonakis, Alisha Schor, Sharon Ong, Devin Neal, Roger D Kamm, H Harry Asada
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37333 (2012)
We demonstrate ensemble three-dimensional cell cultures and quantitative analysis of angiogenic growth from uniform endothelial monolayers. Our approach combines two key elements: a micro-fluidic assay that enables parallelized angiogenic growth inst
Externí odkaz:
https://doaj.org/article/7b95e2d5ac79447f9c6fe3783d8bf917
Autor:
Alexis N. Pulliam, Alyssa F. Pybus, David A. Gaul, Samuel G. Moore, Levi B. Wood, Facundo M. Fernández, Michelle C. LaPlaca
Publikováno v:
Metabolites, Vol 14, Iss 3, p 133 (2024)
Traumatic brain injury (TBI) is a significant source of disability in the United States and around the world and may lead to long-lasting cognitive deficits and a decreased quality of life for patients across injury severities. Following the primary
Externí odkaz:
https://doaj.org/article/aeea03b3b0b24d62b6e2747b295ee6b3
Autor:
Sruti Rayaprolu, Sara Bitarafan, Juliet V. Santiago, Ranjita Betarbet, Sydney Sunna, Lihong Cheng, Hailian Xiao, Ruth S. Nelson, Prateek Kumar, Pritha Bagchi, Duc M. Duong, Annie M. Goettemoeller, Viktor János Oláh, Matt Rowan, Allan I. Levey, Levi B. Wood, Nicholas T. Seyfried, Srikant Rangaraju
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Current isolation-based approaches for cell type-specific proteomics pose several challenges. Here, the authors present an approach for in vivo cell type-specific protein labeling to characterize proteomic differences between neurons and astrocytes i
Externí odkaz:
https://doaj.org/article/0366b13af39b4d438b5baee2a2a9c33d
Autor:
Elena Galea, Laura D. Weinstock, Raquel Larramona-Arcas, Alyssa F. Pybus, Lydia Giménez-Llort, Carole Escartin, Levi B. Wood
Publikováno v:
Neurobiology of Disease, Vol 166, Iss , Pp 105655- (2022)
The phenotypic transformation of astrocytes in Alzheimer's disease (AD) is still not well understood. Recent analyses based on single-nucleus RNA sequencing of postmortem Alzheimer's disease (AD) samples are limited by the low number of sequenced ast
Externí odkaz:
https://doaj.org/article/430adb167f2847c48b191784dd57b436
Autor:
Sitara B. Sankar, Carmen Infante-Garcia, Laura D. Weinstock, Juan Jose Ramos-Rodriguez, Carmen Hierro-Bujalance, Cecilia Fernandez-Ponce, Levi B. Wood, Monica Garcia-Alloza
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-15 (2020)
Abstract Background Diabetes is a risk factor for developing Alzheimer’s disease (AD); however, the mechanism by which diabetes can promote AD pathology remains unknown. Diabetes results in diverse molecular changes in the brain, including dysregul
Externí odkaz:
https://doaj.org/article/7227b2e433964c7c8ff4aaf50438bd39
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2022)
Externí odkaz:
https://doaj.org/article/a744068f6e1443719bc87f1129824eaa
Autor:
Sitara B. Sankar, Alyssa F. Pybus, Amanda Liew, Bharat Sanders, Kajol J. Shah, Levi B. Wood, Erin M. Buckley
Publikováno v:
Neurobiology of Disease, Vol 124, Iss , Pp 544-554 (2019)
Previous work has shown that non-invasive optical measurement of low cerebral blood flow (CBF) is an acute biomarker of poor long-term cognitive outcome after repetitive mild traumatic brain injury (rmTBI). Herein, we explore the relationship between
Externí odkaz:
https://doaj.org/article/7236c66246e54f41a27930619709ecfe