Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Levi B Wood"'
Autor:
Kanupriya R. Daga, Andrew M. Larey, Maria G. Morfin, Kailin Chen, Sara Bitarafan, Jana M. Carpenter, Hannah M. Hynds, Kelly M. Hines, Levi B. Wood, Ross A. Marklein
Publikováno v:
Journal of Biological Engineering, Vol 18, Iss 1, Pp 1-21 (2024)
Abstract Background Mesenchymal stromal cell derived extracellular vesicles (MSC-EVs) are a promising therapeutic for neuroinflammation. MSC-EVs can interact with microglia, the resident immune cells of the brain, to exert their immunomodulatory effe
Externí odkaz:
https://doaj.org/article/ed07ae149d72409faf0f21728dc5d06e
Autor:
Alyssa F. Pybus, Sara Bitarafan, Rowan O. Brothers, Alivia Rohrer, Arushi Khaitan, Felix Rivera Moctezuma, Kareena Udeshi, Brae Davies, Sydney Triplett, Martin N. Griffin, Eric B. Dammer, Srikant Rangaraju, Erin M. Buckley, Levi B. Wood
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-21 (2024)
Abstract Repetitive mild traumatic brain injuries (rmTBI) sustained within a window of vulnerability can result in long term cognitive deficits, depression, and eventual neurodegeneration associated with tau pathology, amyloid beta (Aβ) plaques, gli
Externí odkaz:
https://doaj.org/article/33fb43db821e412cb4a51344d8ea1517
Autor:
Prateek Kumar, Annie M. Goettemoeller, Claudia Espinosa-Garcia, Brendan R. Tobin, Ali Tfaily, Ruth S. Nelson, Aditya Natu, Eric B. Dammer, Juliet V. Santiago, Sneha Malepati, Lihong Cheng, Hailian Xiao, Duc D. Duong, Nicholas T. Seyfried, Levi B. Wood, Matthew J. M. Rowan, Srikant Rangaraju
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-26 (2024)
Abstract Dysfunction in fast-spiking parvalbumin interneurons (PV-INs) may represent an early pathophysiological perturbation in Alzheimer’s Disease (AD). Defining early proteomic alterations in PV-INs can provide key biological and translationally
Externí odkaz:
https://doaj.org/article/4a3d7575d66340e7b52ba0e5a848ab2b
Autor:
Alexis N. Pulliam, Alyssa F. Pybus, David A. Gaul, Samuel G. Moore, Levi B. Wood, Facundo M. Fernández, Michelle C. LaPlaca
Publikováno v:
Metabolites, Vol 14, Iss 3, p 133 (2024)
Traumatic brain injury (TBI) is a significant source of disability in the United States and around the world and may lead to long-lasting cognitive deficits and a decreased quality of life for patients across injury severities. Following the primary
Externí odkaz:
https://doaj.org/article/aeea03b3b0b24d62b6e2747b295ee6b3
Autor:
Sruti Rayaprolu, Sara Bitarafan, Juliet V. Santiago, Ranjita Betarbet, Sydney Sunna, Lihong Cheng, Hailian Xiao, Ruth S. Nelson, Prateek Kumar, Pritha Bagchi, Duc M. Duong, Annie M. Goettemoeller, Viktor János Oláh, Matt Rowan, Allan I. Levey, Levi B. Wood, Nicholas T. Seyfried, Srikant Rangaraju
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Current isolation-based approaches for cell type-specific proteomics pose several challenges. Here, the authors present an approach for in vivo cell type-specific protein labeling to characterize proteomic differences between neurons and astrocytes i
Externí odkaz:
https://doaj.org/article/0366b13af39b4d438b5baee2a2a9c33d
Autor:
Ari Sudwarts, Supriya Ramesha, Tianwen Gao, Moorthi Ponnusamy, Shuai Wang, Mitchell Hansen, Alena Kozlova, Sara Bitarafan, Prateek Kumar, David Beaulieu-Abdelahad, Xiaolin Zhang, Lisa Collier, Charles Szekeres, Levi B. Wood, Jubao Duan, Gopal Thinakaran, Srikant Rangaraju
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-27 (2022)
Abstract Background The BIN1 locus contains the second-most significant genetic risk factor for late-onset Alzheimer’s disease. BIN1 undergoes alternate splicing to generate tissue- and cell-type-specific BIN1 isoforms, which regulate membrane dyna
Externí odkaz:
https://doaj.org/article/5b885f3d291245d3b19ec792e0b820ed
Autor:
Elena Galea, Laura D. Weinstock, Raquel Larramona-Arcas, Alyssa F. Pybus, Lydia Giménez-Llort, Carole Escartin, Levi B. Wood
Publikováno v:
Neurobiology of Disease, Vol 166, Iss , Pp 105655- (2022)
The phenotypic transformation of astrocytes in Alzheimer's disease (AD) is still not well understood. Recent analyses based on single-nucleus RNA sequencing of postmortem Alzheimer's disease (AD) samples are limited by the low number of sequenced ast
Externí odkaz:
https://doaj.org/article/430adb167f2847c48b191784dd57b436
Autor:
Sruti Rayaprolu, Tianwen Gao, Hailian Xiao, Supriya Ramesha, Laura D. Weinstock, Jheel Shah, Duc M. Duong, Eric B. Dammer, James A. Webster, James J. Lah, Levi B. Wood, Ranjita Betarbet, Allan I. Levey, Nicholas T. Seyfried, Srikant Rangaraju
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-22 (2020)
Abstract Background Proteomic characterization of microglia provides the most proximate assessment of functionally relevant molecular mechanisms of neuroinflammation. However, microglial proteomics studies have been limited by low cellular yield and
Externí odkaz:
https://doaj.org/article/d7c72d1d44654f4abfd3eb413217f735
Autor:
Sitara B. Sankar, Carmen Infante-Garcia, Laura D. Weinstock, Juan Jose Ramos-Rodriguez, Carmen Hierro-Bujalance, Cecilia Fernandez-Ponce, Levi B. Wood, Monica Garcia-Alloza
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-15 (2020)
Abstract Background Diabetes is a risk factor for developing Alzheimer’s disease (AD); however, the mechanism by which diabetes can promote AD pathology remains unknown. Diabetes results in diverse molecular changes in the brain, including dysregul
Externí odkaz:
https://doaj.org/article/7227b2e433964c7c8ff4aaf50438bd39
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2022)
Externí odkaz:
https://doaj.org/article/a744068f6e1443719bc87f1129824eaa