Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Levi, Todd"'
Autor:
Thomas A. Reh, Levi Todd
Publikováno v:
Cold Spring Harbor perspectives in biology. 14(6)
The regenerative capacity of the vertebrate retina varies substantially across species. Whereas fish and amphibians can regenerate functional retina, mammals do not. In this perspective piece, we outline the various strategies nonmammalian vertebrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f08a0f495132229e69c79abb5e7bbc29
https://pubmed.ncbi.nlm.nih.gov/34580118
https://pubmed.ncbi.nlm.nih.gov/34580118
Autor:
Levi Todd, Marcus J. Hooper, Alexandra K. Haugan, Connor Finkbeiner, Nikolas Jorstad, Nicholas Radulovich, Claire K. Wong, Phoebe C. Donaldson, Wesley Jenkins, Qiang Chen, Fred Rieke, Thomas A. Reh
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109857- (2021)
Summary: Regenerative neuroscience aims to stimulate endogenous repair in the nervous system to replace neurons lost from degenerative diseases. Recently, we reported that overexpressing the transcription factor Ascl1 in Müller glia (MG) is sufficie
Externí odkaz:
https://doaj.org/article/4e22db68d209415691d36918e753da31
Autor:
Levi Todd, Isabella Palazzo, Lilianna Suarez, Xiaoyu Liu, Leo Volkov, Thanh V. Hoang, Warren A. Campbell, Seth Blackshaw, Ning Quan, Andy J. Fischer
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-19 (2019)
Abstract Background Microglia and inflammation have context-specific impacts upon neuronal survival in different models of central nervous system (CNS) disease. Herein, we investigate how inflammatory mediators, including microglia, interleukin 1 bet
Externí odkaz:
https://doaj.org/article/6ec390cb647a4ea68a86e0194b3aa2c9
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108507- (2020)
Summary: The innate immune system plays key roles in tissue regeneration. For example, microglia promote neurogenesis in Müller glia in birds and fish after injury. Although mammalian retina does not normally regenerate, neurogenesis can be induced
Externí odkaz:
https://doaj.org/article/532e3cf03b544f6a978bc547349489ed
Autor:
Nikolas L. Jorstad, Matthew S. Wilken, Levi Todd, Connor Finkbeiner, Paul Nakamura, Nicholas Radulovich, Marcus J. Hooper, Alex Chitsazan, Brent A. Wilkerson, Fred Rieke, Thomas A. Reh
Publikováno v:
Cell Reports, Vol 30, Iss 7, Pp 2195-2208.e5 (2020)
Summary: Müller glia (MG) serve as sources for retinal regeneration in non-mammalian vertebrates. We find that this process can be induced in mouse MG, after injury, by transgenic expression of the proneural transcription factor Ascl1 and the HDAC i
Externí odkaz:
https://doaj.org/article/92d77537dc5a471fb270672b687e7c22
Autor:
Margaret Hamner, Ashley McDonough, Cara Nielson, Davin Gong, Levi Todd, German Rojas, Thomas Reh, Bruce R Ransom, Jonathan R Weinstein
Publikováno v:
Stroke. 54
Background: Ischemic preconditioning (IPC) is a robust protective phenomenon whereby brief ischemic exposure confers protection against a subsequent prolonged ischemic challenge. IPC has been studied primarily in gray matter predominant models, howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf2f756b44d7c54628905b3760598d87
https://doi.org/10.1161/str.54.suppl_1.wp243
https://doi.org/10.1161/str.54.suppl_1.wp243
Autor:
Levi Todd, Wesley Jenkins, Connor Finkbeiner, Marcus J. Hooper, Phoebe C. Donaldson, Marina Pavlou, Juliette Wohlschlegel, Norianne Ingram, Fred Rieke, Thomas A. Reh
Publikováno v:
Science advances. 8(47)
Many neurodegenerative diseases cause degeneration of specific types of neurons. For example, glaucoma leads to death of retinal ganglion cells, leaving other neurons intact. Neurons are not regenerated in the adult mammalian central nervous system.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7abafb2946f16f79f69204d3e7b1a21c
https://pubmed.ncbi.nlm.nih.gov/36417510
https://pubmed.ncbi.nlm.nih.gov/36417510
Ongoing cell replacement studies and clinical trials have demonstrated the need to control donor and newborn cell behavior within their target tissue. Here we present a methodology to guide stem cell-derived and endogenously regenerated neurons by en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fdfc897b752abf628a7019689f501cf
https://doi.org/10.1101/2022.09.29.510158
https://doi.org/10.1101/2022.09.29.510158
Müller glia (MG) in mammalian retinas are incapable of regenerating neurons after damage, whereas the MG in lower vertebrates regenerate functional neurons. Identification networks that regulate MG-mediated regeneration is key to harnessing the rege
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74b709ca496de8636392cef6a910ae37
https://doi.org/10.1101/2021.10.05.463152
https://doi.org/10.1101/2021.10.05.463152
Autor:
Alexandra K. Haugan, Wesley Jenkins, Thomas A. Reh, Phoebe C. Donaldson, Qiang Chen, Claire K. Wong, Connor Finkbeiner, Marcus J. Hooper, Nikolas L. Jorstad, Levi Todd, Nicholas Radulovich, Fred Rieke
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109857-(2021)
Cell Rep
Cell Rep
Summary: Regenerative neuroscience aims to stimulate endogenous repair in the nervous system to replace neurons lost from degenerative diseases. Recently, we reported that overexpressing the transcription factor Ascl1 in Müller glia (MG) is sufficie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2d5a3fe0e7cb28f6950648d4dbef4f6
http://www.sciencedirect.com/science/article/pii/S2211124721013243
http://www.sciencedirect.com/science/article/pii/S2211124721013243