Alcohol consumption and telomere length: Mendelian randomization clarifies alcohol's effects

Autor: Topiwala, A, Taschler, B, Ebmeier, KP, Smith, S, Zhou, H, Levey, DF, Codd, V, Samani, NJ, Gelernter, J, Nichols, TE, Burgess, S

Funder: UK Medical Research Council (G1001354 & MR/K013351/1) European Commission (Horizon 2020 732592)
Funder: Wellcome Trust WIN
Funder: US Department of Veterans Affairs (I01CX001849)
Funder: Li Ka Shing Centre for Health Informatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f0bb947e63d22b8ff3526dfd497d57e

Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction.

Autor: Braun A; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Shekhar S; Department of Genetics, University of North Carolina at Chapel Hill, North Carolina, USA.; Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA., Levey DF; Department of Psychiatry, Yale School of Medicine, West Haven, CT, USA.; Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA., Straub P; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Kraft J; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Panagiotaropoulou GM; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Heilbron K; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Awasthi S; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Meleka Hanna R; Department of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Neuroscience Clinical Research Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany., Hoffmann S; Department of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Neuroscience Clinical Research Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany., Stein M; Department of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Neuroscience Clinical Research Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Department of Neurology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts, USA., Lehnerer S; Department of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Neuroscience Clinical Research Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany., Mergenthaler P; Department of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Neuroscience Clinical Research Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., Elnahas AG; Institute of Genomics, University of Tartu, Tartu, Estonia., Topaloudi A; Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA., Koromina M; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Palviainen T; Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland., Asbjornsdottir B; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Stefansson H; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Skuladóttir AT; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Jónsdóttir I; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Stefansson K; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Reis K; Institute of Genomics, University of Tartu, Tartu, Estonia., Esko T; Institute of Genomics, University of Tartu, Tartu, Estonia., Palotie A; Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland., Leypoldt F; Department of Neurology, Kiel University, Kiel, Schleswig-Holstein, Germany., Stein MB; Department of Psychiatry and School of Public Health, University of California San Diego, La Jolla, California, USA.; Veterans Affairs San Diego Healthcare System, Psychiatry Service, San Diego, California, USA., Fontanillas P; 23andMe, Inc., Sunnyvale, California, USA., Kaprio J; Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland., Gelernter J; Department of Psychiatry, Yale School of Medicine, West Haven, CT, USA.; Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA., Davis LK; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Paschou P; Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA., Tannemaat MR; Leiden University Medical Center, Department of Neurology, Leiden, Zuid Holland, Netherlands., Verschuuren JJGM; Leiden University Medical Center, Department of Neurology, Leiden, Zuid Holland, Netherlands., Kuhlenbäumer G; Department of Neurology, Kiel University, Kiel, Schleswig-Holstein, Germany.; Neuroimmunology, Kiel University, Institute of Clinical Chemistry, Kiel, Schleswig-Holstein, Germany., Gregersen PK; Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York, NY, USA., Huijbers MG; Leiden University Medical Center, Department of Neurology, Leiden, Zuid Holland, Netherlands.; Leiden University Medical Center, Department of Human Genetics, Leiden, Zuid Holland, Netherlands., Stascheit F; Department of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Neuroscience Clinical Research Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany., Meisel A; Department of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Neuroscience Clinical Research Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.; Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany., Ripke S; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany. sripke@broadinstitute.org.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. sripke@broadinstitute.org.; German Center for Mental Health (DZPG), partner site Berlin/Potsdam, Berlin, Germany. sripke@broadinstitute.org.

Publikováno v: Nature communications [Nat Commun] 2024 Nov 13; Vol. 15 (1), pp. 9839. Date of Electronic Publication: 2024 Nov 13.

Association between cannabis use and brain structure and function: an observational and Mendelian randomisation study.

Autor: Ishrat S; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK saba.ishrat@stx.ox.ac.uk.; Nuffield Department of Population Health, Big Data Institute, University of Oxford, Oxford, UK., Levey DF; Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; Department of Psychiatry, Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA., Gelernter J; Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; Department of Psychiatry, Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA., Ebmeier K; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.; Wellcome Centre for Integrative Neuroimaging (WIN), Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK., Topiwala A; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.; Nuffield Department of Population Health, Big Data Institute, University of Oxford, Oxford, UK.

Publikováno v: BMJ mental health [BMJ Ment Health] 2024 Oct 30; Vol. 27 (1). Date of Electronic Publication: 2024 Oct 30.

Epigenetic and Genetic Profiling of Comorbidity Patterns among Substance Dependence Diagnoses.

Autor: Pathak GA, Pietrzak RH, Lacobelle A, Overstreet C, Wendt FR, Deak JD, Friligkou E, Nunez Y, Montalvo-Ortiz JL, Levey DF, Kranzler HR, Gelernter J, Polimanti R

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Oct 08. Date of Electronic Publication: 2024 Oct 08.

Genetic Insights into Externalizing and Internalizing Traits through Integration of the Research Domain Criteria and Hierarchical Taxonomy of Psychopathology.

Autor: Davis CN; Mental Illness Research, Education and Clinical Center, Crescenz VAMC, Philadelphia, PA, USA.; Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA., Khan Y; Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA., Toikumo S; Mental Illness Research, Education and Clinical Center, Crescenz VAMC, Philadelphia, PA, USA.; Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA., Jinwala Z; Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA., Boomsma DI; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, The Netherlands and Amsterdam Reproduction and Development Research Institute, Amsterdam, The Netherlands., Levey DF; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; VA Connecticut Healthcare Center, West Haven, CT, USA., Gelernter J; VA Connecticut Healthcare Center, West Haven, CT, USA.; Departments of Psychiatry, Genetics, and Neuroscience, Yale University School of Medicine, New Haven, CT, USA., Kember RL; Mental Illness Research, Education and Clinical Center, Crescenz VAMC, Philadelphia, PA, USA.; Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA., Kranzler HR; Mental Illness Research, Education and Clinical Center, Crescenz VAMC, Philadelphia, PA, USA.; Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Sep 24. Date of Electronic Publication: 2024 Sep 24.