Designer high-density lipoprotein particles enhance endothelial barrier function and suppress inflammation.

Autor: Lin YC; Vascular Biology Program, Boston Children's Hospital and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA., Swendeman S; Vascular Biology Program, Boston Children's Hospital and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA., Moreira IS; Department of Life Sciences, University of Coimbra, Calçada Martim de Freitas, 3000-456 Coimbra, Portugal.; CNC-Center for Neuroscience and Cell Biology, Center for Innovative Biomedicine and Biotechnology, University of Coimbra, 3000-456 Coimbra, Portugal., Ghosh A; Vascular Biology Program, Boston Children's Hospital and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA., Kuo A; Vascular Biology Program, Boston Children's Hospital and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA., Rosário-Ferreira N; CNC-Center for Neuroscience and Cell Biology, Center for Innovative Biomedicine and Biotechnology, University of Coimbra, 3000-456 Coimbra, Portugal., Guo S; Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115 USA., Culbertson A; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA., Levesque MV; Vascular Biology Program, Boston Children's Hospital and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA., Cartier A; Vascular Biology Program, Boston Children's Hospital and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA., Seno T; Vascular Biology Program, Boston Children's Hospital and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA., Schmaier A; Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115 USA.; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA., Galvani S; Vascular Biology Program, Boston Children's Hospital and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA., Inoue A; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi 980-8578, Japan., Parikh SM; Division of Nephrology and Department of Medicine, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA., FitzGerald GA; Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA., Zurakowski D; Department of Anesthesia and Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA., Liao M; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.; Department of Chemical Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.; Institute for Biological Electron Microscopy, Southern University of Science and Technology, Shenzhen 518055, China., Flaumenhaft R; Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115 USA., Gümüş ZH; Department of Genetics and Genomic Sciences and Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Hla T; Vascular Biology Program, Boston Children's Hospital and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA.

Publikováno v: Science signaling [Sci Signal] 2024 Feb 20; Vol. 17 (824), pp. eadg9256. Date of Electronic Publication: 2024 Feb 20.

Sphingosine 1-Phosphate Receptor Signaling Establishes AP-1 Gradients to Allow for Retinal Endothelial Cell Specialization.

Autor: Yanagida K; Vascular Biology Program, Boston Children's Hospital, Department of Surgery, Harvard Medical School, Boston, MA, USA., Engelbrecht E; Vascular Biology Program, Boston Children's Hospital, Department of Surgery, Harvard Medical School, Boston, MA, USA., Niaudet C; Vascular Biology Program, Boston Children's Hospital, Department of Surgery, Harvard Medical School, Boston, MA, USA., Jung B; Vascular Biology Program, Boston Children's Hospital, Department of Surgery, Harvard Medical School, Boston, MA, USA., Gaengel K; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden., Holton K; Harvard Medical School Research Computing, Boston, MA, USA., Swendeman S; Vascular Biology Program, Boston Children's Hospital, Department of Surgery, Harvard Medical School, Boston, MA, USA., Liu CH; Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Levesque MV; Vascular Biology Program, Boston Children's Hospital, Department of Surgery, Harvard Medical School, Boston, MA, USA., Kuo A; Vascular Biology Program, Boston Children's Hospital, Department of Surgery, Harvard Medical School, Boston, MA, USA., Fu Z; Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Smith LEH; Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Betsholtz C; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; ICMC (Integrated Cardio Metabolic Centre), Karolinska Institutet, Novum, Huddinge, Sweden., Hla T; Vascular Biology Program, Boston Children's Hospital, Department of Surgery, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address: timothy.hla@childrens.harvard.edu.

Publikováno v: Developmental cell [Dev Cell] 2020 Mar 23; Vol. 52 (6), pp. 779-793.e7. Date of Electronic Publication: 2020 Feb 13.