Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Levente Ondi"'
Autor:
Szabolcs Sipos, Balázs Bálint, Zoltán B. Szabó, Levente Ondi, Márton Csékei, Zoltán Szlávik, Ágnes Proszenyák, James B. Murray, James Davidson, Ijen Chen, Pawel Dokurno, Allan E. Surgenor, Christopher Pedder, Roderick E. Hubbard, Ana-Leticia Maragno, Maia Chanrion, Frederic Colland, Olivier Geneste, András Kotschy
Publikováno v:
ACS Omega, Vol 6, Iss 34, Pp 22073-22102 (2021)
Externí odkaz:
https://doaj.org/article/8920fac56cd04386b0126955f672d5f2
Autor:
I-Jen Chen, Proszenyák Ágnes, Zoltán B. Szabó, Levente Ondi, Csékei Márton, Olivier Geneste, Szabolcs Sipos, Allan E. Surgenor, Frédéric Colland, C. Pedder, Maïa Chanrion, Balázs Bálint, Ana-Leticia Maragno, Roderick E. Hubbard, Szlávik Zoltán, Pawel Dokurno, András Kotschy, James B. Murray, James R. Davidson
Publikováno v:
ACS Omega, Vol 6, Iss 34, Pp 22073-22102 (2021)
ACS Omega
ACS Omega
Following the identification of thieno[2,3-d]pyrimidine-based selective and potent inhibitors of MCL-1, we explored the effect of core swapping at different levels of advancement. During hit-to-lead optimization, X-ray-guided S-N replacement in the c
Publikováno v:
Organic Process Research & Development. 20:1709-1716
Molybdenum- and tungsten-based olefin metathesis catalysts have demonstrated excellent results in the control of cis (Z-) selectivity as well as enantioselectivity. However, their air and moisture sensitivity, which requires the use of a glovebox, ha
Autor:
James A. H. Murray, Fabien Melchiore, Natalia Matassova, C. Pedder, Frédéric Colland, Catherine Chang, Levente Ondi, Laura C. A. Galbraith, Pawel Dokurno, Andrew W. Roberts, Chris D. Riffkin, Nolwen Guigal-Stephan, Proszenyák Ágnes, John A. Hickman, Andreas Strasser, Aurélie Studeny, Gaëlle Lysiak-Auvity, András Kotschy, Gemma L. Kelly, Fabienne Gravé, Ghislaine Guasconi, Brandon J. Aubrey, Attila Paczal, Julia Smith, Szlávik Zoltán, Gabor Radics, Brian Lockhart, David C.S. Huang, Maïa Chanrion, Gaëtane Le Toumelin-Braizat, Jia-Nan Gong, Nicolas Cauquil, Szabolcs Sipos, Alan P. Robertson, Giovanna Pomilio, James Edward Paul Davidson, Zoltán B. Szabó, Ana Leticia Maragno, Chris Graham, Marco J Herold, Gábor Blasko, Margs S. Brennan, Anne-Marie Girard, Allan E. Surgenor, Andrew H. Wei, Csékei Márton, Olivier Geneste, Chen I-Jen, Alain Bruno, David J. Segal, Guillaume Lessene, Balázs Bálint, Donia M Moujalled
Publikováno v:
Nature. 538:477-482
Avoidance of apoptosis is critical for the development and sustained growth of tumours. The pro-survival protein myeloid cell leukemia 1 (MCL1) is overexpressed in many cancers, but the development of small molecules targeting this protein that are a
Autor:
Didier Demarles, James Edward Paul Davidson, Levente Ondi, Allan E. Surgenor, Frédéric Colland, Attila Paczal, Marion Zarka, Alan P. Robertson, Zoltán B. Szabó, András Kotschy, Julia Smith, Perron-Sierra Françoise, Gabor Radics, Audrey Claperon, Ben Davis, Pawel Dokurno, Szlávik Zoltán, Csékei Márton, Gaetane LeToumelin-Braizat, Roderick E. Hubbard, Chen I-Jen, C. Pedder, Olivier Geneste, James Murray, Nicolas Cauquil
Publikováno v:
Journal of medicinal chemistry. 62(15)
Myeloid cell leukemia 1 (Mcl-1), an antiapoptotic member of the Bcl-2 family of proteins, whose upregulation when observed in human cancers is associated with high tumor grade, poor survival, and resistance to chemotherapy, has emerged as an attracti
Autor:
András Kotschy, Isabelle Theret, Attila Paczal, Frédéric De Ceuninck, Zoltán B. Szabó, Catherine Bernard, Alain Ktorza, Balázs Bálint, Csaba Wéber, Perron-Sierra Françoise, Levente Ondi
Publikováno v:
Journal of Medicinal Chemistry. 59:687-706
7-Azaindole has been identified as a novel bidentate anchor point for allosteric glucokinase activators. A systematic investigation around three principal parts of the new small molecule glucokinase activators led to a robust SAR in agreement with st
Publikováno v:
European Journal of Organic Chemistry. 2006:1593-1598
5-Pyrimidyllithium species are fairly stable when the metal is flanked by two electron-withdrawing substituents such as trifluoromethyl and chlorine or bromine. Thus, the corresponding 5-carboxylic acids are produced in high yields from 4,5-dibromo-6
Autor:
Levente Ondi, Manfred Schlosser
Publikováno v:
European Journal of Organic Chemistry; May2006, Vol. 2006 Issue 10, p2417-2422, 6p
Publikováno v:
European Journal of Organic Chemistry; Sep2004, Vol. 2004 Issue 17, p3714-3718, 5p
Mono- and disubstituted 2-bromo-3-fluoroquinolines are readily accessible. They can be converted into the 3-fluoroquinoline-2-carboxylic acids by consecutive halogen/metal permutation and into the 2-bromo-3-fluoroquinoline-4-carboxylic acids by conse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afafa960a37d4bd63f98700c89141339
https://infoscience.epfl.ch/record/81779
https://infoscience.epfl.ch/record/81779