Insulin Prevents Hypercholesterolemia by Suppressing 12α-Hydroxylated Bile Acids.

Autor: Semova I; Division of Endocrinology (I.S., A.E.L., J.K., M.E.G., A.V.L., J.M., S.S.A., D.-J.S., S.C., S.B.B.), Boston Children's Hospital, Harvard Medical School, MA., Levenson AE; Division of Endocrinology (I.S., A.E.L., J.K., M.E.G., A.V.L., J.M., S.S.A., D.-J.S., S.C., S.B.B.), Boston Children's Hospital, Harvard Medical School, MA., Krawczyk J; Division of Endocrinology (I.S., A.E.L., J.K., M.E.G., A.V.L., J.M., S.S.A., D.-J.S., S.C., S.B.B.), Boston Children's Hospital, Harvard Medical School, MA., Bullock K; Broad Institute of MIT and Harvard, Cambridge, MA (K.B., C.B.C.)., Gearing ME; Division of Endocrinology (I.S., A.E.L., J.K., M.E.G., A.V.L., J.M., S.S.A., D.-J.S., S.C., S.B.B.), Boston Children's Hospital, Harvard Medical School, MA., Ling AV; Division of Endocrinology (I.S., A.E.L., J.K., M.E.G., A.V.L., J.M., S.S.A., D.-J.S., S.C., S.B.B.), Boston Children's Hospital, Harvard Medical School, MA., Williams KA; Biostatistics and Research Design Center, ICCTR, Boston Children's Hospital, MA (K.A.W.)., Miao J; Division of Endocrinology (I.S., A.E.L., J.K., M.E.G., A.V.L., J.M., S.S.A., D.-J.S., S.C., S.B.B.), Boston Children's Hospital, Harvard Medical School, MA., Adamson SS; Division of Endocrinology (I.S., A.E.L., J.K., M.E.G., A.V.L., J.M., S.S.A., D.-J.S., S.C., S.B.B.), Boston Children's Hospital, Harvard Medical School, MA., Shin DJ; Division of Endocrinology (I.S., A.E.L., J.K., M.E.G., A.V.L., J.M., S.S.A., D.-J.S., S.C., S.B.B.), Boston Children's Hospital, Harvard Medical School, MA., Chahar S; Division of Endocrinology (I.S., A.E.L., J.K., M.E.G., A.V.L., J.M., S.S.A., D.-J.S., S.C., S.B.B.), Boston Children's Hospital, Harvard Medical School, MA., Graham MJ; Ionis Pharmaceuticals, Carlsbad, CA (M.J.G., R.M.C.)., Crooke RM; Ionis Pharmaceuticals, Carlsbad, CA (M.J.G., R.M.C.)., Hagey LR; Department of Medicine, University of California, San Diego (L.R.H.)., Vicent D; Instituto de Investigación Sanitaria del Hospital Universitario La Paz (IdiPAZ), Madrid, Spain (D.V.)., de Ferranti SD; Department of Cardiology (S.D.d.F.), Boston Children's Hospital, Harvard Medical School, MA., Kidambi S; Department of Medicine, Medical College of Wisconsin, Milwaukee (S.K.)., Clish CB; Broad Institute of MIT and Harvard, Cambridge, MA (K.B., C.B.C.)., Biddinger SB; Division of Endocrinology (I.S., A.E.L., J.K., M.E.G., A.V.L., J.M., S.S.A., D.-J.S., S.C., S.B.B.), Boston Children's Hospital, Harvard Medical School, MA.

Publikováno v: Circulation [Circulation] 2022 Mar 29; Vol. 145 (13), pp. 969-982. Date of Electronic Publication: 2022 Feb 23.

Type 1 diabetes is associated with an increase in cholesterol absorption markers but a decrease in cholesterol synthesis markers in a young adult population.

Autor: Semova I; Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Levenson AE; Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Krawczyk J; Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Bullock K; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Williams KA; Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Biostatistics and Research Design Center, Boston Children's Hospital, Boston, MA, USA., Wadwa RP; Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, CO, USA., Shah AS; Division of Endocrinology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH, USA., Khoury PR; Division of Endocrinology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH, USA., Kimball TR; Division of Cardiology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH, USA., Urbina EM; Division of Cardiology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH, USA., de Ferranti SD; Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Bishop FK; Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, CO, USA., Maahs DM; Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, CO, USA., Dolan LM; Division of Endocrinology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH, USA., Clish CB; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Biddinger SB; Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: sudha.biddinger@childrens.harvard.edu.

Publikováno v: Journal of clinical lipidology [J Clin Lipidol] 2019 Nov - Dec; Vol. 13 (6), pp. 940-946. Date of Electronic Publication: 2019 Sep 25.

PCSK9 Is Increased in Youth With Type 1 Diabetes.

Autor: Levenson AE; Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA., Wadwa RP; Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, CO., Shah AS; Division of Endocrinology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH., Khoury PR; Division of Endocrinology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH., Kimball TR; Division of Cardiology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH., Urbina EM; Division of Cardiology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH., de Ferranti SD; Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MA., Bishop FK; Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, CO., Maahs DM; Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, CO.; Division of Endocrinology and Diabetes, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA., Dolan LM; Division of Endocrinology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH., Biddinger SB; Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA sudha.biddinger@childrens.harvard.edu.

Publikováno v: Diabetes care [Diabetes Care] 2017 Jul; Vol. 40 (7), pp. e85-e87. Date of Electronic Publication: 2017 Jun 06.

The Role of Proprotein Convertase Subtilisin/Kexin Type 9 in Nephrotic Syndrome-Associated Hypercholesterolemia.

Autor: Haas ME; From Division of Endocrinology, Boston Children's Hospital; Department of Pediatrics, Harvard Medical School, MA (M.E.H., A.E.L., X.S., W.-H.L., S.B.B.); Touchstone Diabetes Center, Departments of Internal Medicine and Cell Biology, University of Texas Southwestern Medical Center, Dallas (J.M.R., P.E.S.); Division of Cardiology, Boston Children's Hospital; Department of Pediatrics, Harvard Medical School, MA (S.D.d.F.); Division of Nephrology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA (V.A.S.); and Department of Medicine, Section of Nephrology, Boston University Medical Center, MA (D.J.S.)., Levenson AE; From Division of Endocrinology, Boston Children's Hospital; Department of Pediatrics, Harvard Medical School, MA (M.E.H., A.E.L., X.S., W.-H.L., S.B.B.); Touchstone Diabetes Center, Departments of Internal Medicine and Cell Biology, University of Texas Southwestern Medical Center, Dallas (J.M.R., P.E.S.); Division of Cardiology, Boston Children's Hospital; Department of Pediatrics, Harvard Medical School, MA (S.D.d.F.); Division of Nephrology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA (V.A.S.); and Department of Medicine, Section of Nephrology, Boston University Medical Center, MA (D.J.S.)., Sun X; From Division of Endocrinology, Boston Children's Hospital; Department of Pediatrics, Harvard Medical School, MA (M.E.H., A.E.L., X.S., W.-H.L., S.B.B.); Touchstone Diabetes Center, Departments of Internal Medicine and Cell Biology, University of Texas Southwestern Medical Center, Dallas (J.M.R., P.E.S.); Division of Cardiology, Boston Children's Hospital; Department of Pediatrics, Harvard Medical School, MA (S.D.d.F.); Division of Nephrology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA (V.A.S.); and Department of Medicine, Section of Nephrology, Boston University Medical Center, MA (D.J.S.)., Liao WH; From Division of Endocrinology, Boston Children's Hospital; Department of Pediatrics, Harvard Medical School, MA (M.E.H., A.E.L., X.S., W.-H.L., S.B.B.); Touchstone Diabetes Center, Departments of Internal Medicine and Cell Biology, University of Texas Southwestern Medical Center, Dallas (J.M.R., P.E.S.); Division of Cardiology, Boston Children's Hospital; Department of Pediatrics, Harvard Medical School, MA (S.D.d.F.); Division of Nephrology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA (V.A.S.); and Department of Medicine, Section of Nephrology, Boston University Medical Center, MA (D.J.S.)., Rutkowski JM; From Division of Endocrinology, Boston Children's Hospital; Department of Pediatrics, Harvard Medical School, MA (M.E.H., A.E.L., X.S., W.-H.L., S.B.B.); Touchstone Diabetes Center, Departments of Internal Medicine and Cell Biology, University of Texas Southwestern Medical Center, Dallas (J.M.R., P.E.S.); Division of Cardiology, Boston Children's Hospital; Department of Pediatrics, Harvard Medical School, MA (S.D.d.F.); Division of Nephrology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA (V.A.S.); and Department of Medicine, Section of Nephrology, Boston University Medical Center, MA (D.J.S.)., de Ferranti SD; From Division of Endocrinology, Boston Children's Hospital; Department of Pediatrics, Harvard Medical School, MA (M.E.H., A.E.L., X.S., W.-H.L., S.B.B.); Touchstone Diabetes Center, Departments of Internal Medicine and Cell Biology, University of Texas Southwestern Medical Center, Dallas (J.M.R., P.E.S.); Division of Cardiology, Boston Children's Hospital; Department of Pediatrics, Harvard Medical School, MA (S.D.d.F.); Division of Nephrology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA (V.A.S.); and Department of Medicine, Section of Nephrology, Boston University Medical Center, MA (D.J.S.)., Schumacher VA; From Division of Endocrinology, Boston Children's Hospital; Department of Pediatrics, Harvard Medical School, MA (M.E.H., A.E.L., X.S., W.-H.L., S.B.B.); Touchstone Diabetes Center, Departments of Internal Medicine and Cell Biology, University of Texas Southwestern Medical Center, Dallas (J.M.R., P.E.S.); Division of Cardiology, Boston Children's Hospital; Department of Pediatrics, Harvard Medical School, MA (S.D.d.F.); Division of Nephrology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA (V.A.S.); and Department of Medicine, Section of Nephrology, Boston University Medical Center, MA (D.J.S.)., Scherer PE; From Division of Endocrinology, Boston Children's Hospital; Department of Pediatrics, Harvard Medical School, MA (M.E.H., A.E.L., X.S., W.-H.L., S.B.B.); Touchstone Diabetes Center, Departments of Internal Medicine and Cell Biology, University of Texas Southwestern Medical Center, Dallas (J.M.R., P.E.S.); Division of Cardiology, Boston Children's Hospital; Department of Pediatrics, Harvard Medical School, MA (S.D.d.F.); Division of Nephrology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA (V.A.S.); and Department of Medicine, Section of Nephrology, Boston University Medical Center, MA (D.J.S.)., Salant DJ; From Division of Endocrinology, Boston Children's Hospital; Department of Pediatrics, Harvard Medical School, MA (M.E.H., A.E.L., X.S., W.-H.L., S.B.B.); Touchstone Diabetes Center, Departments of Internal Medicine and Cell Biology, University of Texas Southwestern Medical Center, Dallas (J.M.R., P.E.S.); Division of Cardiology, Boston Children's Hospital; Department of Pediatrics, Harvard Medical School, MA (S.D.d.F.); Division of Nephrology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA (V.A.S.); and Department of Medicine, Section of Nephrology, Boston University Medical Center, MA (D.J.S.)., Biddinger SB; From Division of Endocrinology, Boston Children's Hospital; Department of Pediatrics, Harvard Medical School, MA (M.E.H., A.E.L., X.S., W.-H.L., S.B.B.); Touchstone Diabetes Center, Departments of Internal Medicine and Cell Biology, University of Texas Southwestern Medical Center, Dallas (J.M.R., P.E.S.); Division of Cardiology, Boston Children's Hospital; Department of Pediatrics, Harvard Medical School, MA (S.D.d.F.); Division of Nephrology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA (V.A.S.); and Department of Medicine, Section of Nephrology, Boston University Medical Center, MA (D.J.S.). sudha.biddinger@childrens.harvard.edu.

Publikováno v: Circulation [Circulation] 2016 Jul 05; Vol. 134 (1), pp. 61-72.

Effect of Leptin Replacement on PCSK9 in ob/ob Mice and Female Lipodystrophic Patients.

Autor: Levenson AE; Division of Endocrinology (A.E.L., M.E.H., J.M., S.B.B.), Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Diabetes, Endocrinology, and Obesity Branch (R.J.B., R.M.), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892; and Department of Cardiology (S.D.d.F.), Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115., Haas ME; Division of Endocrinology (A.E.L., M.E.H., J.M., S.B.B.), Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Diabetes, Endocrinology, and Obesity Branch (R.J.B., R.M.), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892; and Department of Cardiology (S.D.d.F.), Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115., Miao J; Division of Endocrinology (A.E.L., M.E.H., J.M., S.B.B.), Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Diabetes, Endocrinology, and Obesity Branch (R.J.B., R.M.), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892; and Department of Cardiology (S.D.d.F.), Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115., Brown RJ; Division of Endocrinology (A.E.L., M.E.H., J.M., S.B.B.), Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Diabetes, Endocrinology, and Obesity Branch (R.J.B., R.M.), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892; and Department of Cardiology (S.D.d.F.), Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115., de Ferranti SD; Division of Endocrinology (A.E.L., M.E.H., J.M., S.B.B.), Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Diabetes, Endocrinology, and Obesity Branch (R.J.B., R.M.), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892; and Department of Cardiology (S.D.d.F.), Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115., Muniyappa R; Division of Endocrinology (A.E.L., M.E.H., J.M., S.B.B.), Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Diabetes, Endocrinology, and Obesity Branch (R.J.B., R.M.), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892; and Department of Cardiology (S.D.d.F.), Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115., Biddinger SB; Division of Endocrinology (A.E.L., M.E.H., J.M., S.B.B.), Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Diabetes, Endocrinology, and Obesity Branch (R.J.B., R.M.), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892; and Department of Cardiology (S.D.d.F.), Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115.

Publikováno v: Endocrinology [Endocrinology] 2016 Apr; Vol. 157 (4), pp. 1421-9. Date of Electronic Publication: 2016 Jan 29.