Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Levenia Baker"'
Autor:
Derek M Erion, Amanda Lapworth, Paul A Amor, Guoyun Bai, Nicholas B Vera, Ronald W Clark, Qingyun Yan, Yimin Zhu, Trenton T Ross, Julie Purkal, Matthew Gorgoglione, Guodong Zhang, Vinicius Bonato, Levenia Baker, Nicole Barucci, Theresa D'Aquila, Alan Robertson, Robert J Aiello, Jiangli Yan, Jeff Trimmer, Timothy P Rolph, Jeffrey A Pfefferkorn
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97139 (2014)
Hyperglycemia resulting from type 2 diabetes mellitus (T2DM) is the main cause of diabetic complications such as retinopathy and neuropathy. A reduction in hyperglycemia has been shown to prevent these associated complications supporting the importan
Externí odkaz:
https://doaj.org/article/646e9e91d00f42f6a75e558c5e50e7cf
Autor:
Caitlin S Kelly, Huyen Nguyen, Weixiu Luo, Katherine S Chapman, Jiat Ling Poon, Levenia Baker, Wendy A Wolf, Magaly Perez-Nieves, Beth D Mitchell, Alexander Stöckl
Publikováno v:
Diabetologie und Stoffwechsel.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f4821a1a4ebdea564a167e3d160359b
https://doi.org/10.1055/s-0043-1767904
https://doi.org/10.1055/s-0043-1767904
Autor:
Karen Atkinson, Timothy P. Rolph, Kris A. Borzilleri, Robert J. Aiello, Levenia Baker, Xiayang Qiu, Theresa D’Aquila, Angel Guzman-Perez, Meihua Tu, Xi Song, Jeffrey A. Pfefferkorn, Shenping Liu, David R. Derksen, Boris A. Chrunyk, James A. Landro, John Litchfield, Kevin J. Filipski, Jane M. Withka, Patricia Bourassa, Francis Bourbonais, Nicole Barrucci
Publikováno v:
Med. Chem. Commun.. 5:802-807
Activation of glucokinase represents a promising strategy for the treatment of type 2 diabetes; however, drug candidates have failed in clinical trials due to narrow therapeutic index between glucose-lowering efficacy and hypoglycemia. Described here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e8d245e5965543e527636b54f722cb3
https://doi.org/10.1039/c4md00027g
https://doi.org/10.1039/c4md00027g
Autor:
Jeffrey A, Pfefferkorn, Meihua, Tu, Kevin J, Filipski, Angel, Guzman-Perez, Jianwei, Bian, Gary E, Aspnes, Matthew F, Sammons, Wei, Song, Jian-Cheng, Li, Christopher S, Jones, Leena, Patel, Tim, Rasmusson, Dongxiang, Zeng, Kapil, Karki, Michael, Hamilton, Richard, Hank, Karen, Atkinson, John, Litchfield, Robert, Aiello, Levenia, Baker, Nicole, Barucci, Patricia, Bourassa, Francis, Bourbonais, Francis, Bourbounais, Theresa, D'Aquila, David R, Derksen, Margit, MacDougall, Alan, Robertson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7100-7105
Glucokinase activators represent a promising potential treatment for patients with Type 2 diabetes. Herein, we report the identification and optimization of a series of novel indazole and pyrazolopyridine based activators leading to the identificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::decea8e508a8ec84ae478bd0cc878d20
https://doi.org/10.1016/j.bmcl.2012.09.082
https://doi.org/10.1016/j.bmcl.2012.09.082
Autor:
Jing Chen, Spiros Liras, Manthena V.S. Varma, Judith L. Treadway, Martha L. Minich, Laurel Sweet, John D. Knafels, Karen Atkinson, Nahor Haddish-Berhane, Angel Guzman-Perez, Benjamin D. Stevens, Alan Robertson, Sharad B. Murdande, David B. Duignan, Mark Ammirati, Timothy P. Rolph, William J. Zavadoski, Christopher S. Jones, Patricia Bourassa, Jeffrey A. Pfefferkorn, John Litchfield, Lili Yao, Kevin J. Filipski, Margit MacDougall, Levenia Baker, John C. Pettersen, Theresa D’Aquila, Ayman El-Kattan, Bo Feng, Francis Bourbonais, Meihua Tu, Robert J. Aiello, Gary Erik Aspnes, Jianwei Bian, David R. Derksen, Paul DaSilva-Jardine, Beijing Tan, James A. Landro, Over Cabrera, Rachel E. Kosa, Hud Lawrence Risley, Shenping Liu, Amanda L. Lapworth, Nicole Barucci
Publikováno v:
Journal of Medicinal Chemistry. 55:1318-1333
Glucokinase is a key regulator of glucose homeostasis, and small molecule allosteric activators of this enzyme represent a promising opportunity for the treatment of type 2 diabetes. Systemically acting glucokinase activators (liver and pancreas) hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4c2ff700899b62627c8e68d3696bfd
https://doi.org/10.1021/jm2014887
https://doi.org/10.1021/jm2014887
Autor:
Timothy P. Rolph, Jiangli Yan, Levenia Baker, Alan Robertson, Vinicius Bonato, Jeffrey A. Pfefferkorn, Paul A. Amor, Jeff K. Trimmer, Theresa D’Aquila, Guoyun Bai, Derek M. Erion, Qingyun Yan, Yimin Zhu, Nicole Barucci, Matthew Gorgoglione, Nicholas B. Vera, Ronald W. Clark, Julie Purkal, Robert J. Aiello, Amanda L. Lapworth, Trenton T. Ross, Guodong Zhang
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97139 (2014)
PLoS ONE
PLoS ONE
Hyperglycemia resulting from type 2 diabetes mellitus (T2DM) is the main cause of diabetic complications such as retinopathy and neuropathy. A reduction in hyperglycemia has been shown to prevent these associated complications supporting the importan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393ea8ae1d1d8d29924dda2ab8dfedf2
http://europepmc.org/articles/PMC4032240?pdf=render
http://europepmc.org/articles/PMC4032240?pdf=render
Autor:
Christopher Bennet, Samuel L White, Kiran Kumar Bokara, Rajanna Bettaiya, Sharada Rajanna, Prabhakara Rao Yallapragada, Levenia Baker, Jon J Brice
Publikováno v:
Free radical research. 41(3)
The objective of this study is to determine the effect of lead (pb) on antioxidant enzymes and lipid peroxidation products in different regions of rat brain. Wistar male rats were treated with lead acetate (500 ppm) through drinking water for a perio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::320ba78f789010c2d4357169781a9aa1
https://pubmed.ncbi.nlm.nih.gov/17364954
https://pubmed.ncbi.nlm.nih.gov/17364954
Autor:
Jeffrey A. Pfefferkorn, Meihua Tu, Kevin J. Filipski, Angel Guzman-Perez, Jianwei Bian, Gary E. Aspnes, Matthew F. Sammons, Wei Song, Jian-Cheng Li, Christopher S. Jones, Leena Patel, Tim Rasmusson, Dongxiang Zeng, Kapil Karki, Michael Hamilton, Richard Hank, Karen Atkinson, John Litchfield, Robert Aiello, Levenia Baker, Nicole Barucci, Patricia Bourassa, Francis Bourbonais, Theresa D’Aquila, David R. Derksen, Margit MacDougall, Alan Robertson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:5022
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e273925fb9d66346c7b51be62c5e68cd
https://doi.org/10.1016/j.bmcl.2013.06.063
https://doi.org/10.1016/j.bmcl.2013.06.063