Výsledky vyhledávání - "Levan J. Lezhava"

Allogeneic T Cells Treated with Amotosalen Prevent Lethal Cytomegalovirus Disease without Producing Graft-versus-Host Disease Following Bone Marrow Transplantation

Autor: John E. Hearst, David L. Jaye, Sabina A. Alexander, Levan J. Lezhava, John W. Gorechlad, John D. Roback, Christopher D. Hillyer, Stephen Mittelstaedt, Mohammad S. Hossain, Sohel Talib, Edmund K. Waller

Publikováno v: The Journal of Immunology. 171:6023-6031

Infusion of donor antiviral T cells can provide protective immunity for recipients of hemopoietic progenitor cell transplants, but may cause graft-vs-host disease (GVHD). Current methods of separating antiviral T cells from the alloreactive T cells t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d30369a78f4f0182e97b804fb6329f1d
https://doi.org/10.4049/jimmunol.171.11.6023

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Transfusion-transmitted cytomegalovirus (CMV) infections in a murine model: characterization of CMV-infected donor mice

Autor: John D. Roback, Levan J. Lezhava, Leon Su, Christopher D. Hillyer, James L. Newman, Natia Saakadze

Publikováno v: Transfusion. 46(6)

BACKGROUND: Donor and recipient mechanisms that modulate the incidence and severity of transfusion-transmitted cytomegalovirus (TT-CMV) are unclear. The kinetics of murine CMV (MCMV) infection in the peripheral blood of donor mice were investigated t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b4b65ea248fb6fb05829c7ca0637a31
https://pubmed.ncbi.nlm.nih.gov/16734804

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Photochemical treatment of platelet concentrates with amotosalen hydrochloride and ultraviolet A light inactivates free and latent cytomegalovirus in a murine transfusion model

Autor: Cetherine T, Jordan, Natia, Saakadze, James L, Newman, Levan J, Lezhava, Tanya T, Maiers, Whitney M, Hillyer, John D, Roback, Christopher D, Hillyer

Publikováno v: Transfusion. 44(8)

A photochemical treatment (PCT) process utilizing amotosalen hydrochloride and long wavelength UVA light has been developed to inactivate pathogens in PLTs. This study investigated the effects of amotosalen/UVA treatment on free and latent murine CMV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::86150a4ac5f66f552e6143c027387d78
https://pubmed.ncbi.nlm.nih.gov/15265119

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Live-Attenuated and Novel Non-Replicating Listeria Vaccines Encoding CMV Antigen Produce Persistent Functional Antiviral Immunity

Autor: William S. Luckett, Christopher D. Hillyer, Levan J. Lezhava, Thomas W. Dubensky, John D. Roback, Martin Giedlin

Publikováno v: Blood. 106:575-575

Background: We previously described a live-attenuated (L/A) Listeria monocytogenes (Lm)-based vaccine encoding murine CMV (MCMV) epitopes (Lm-MCMV) that effectively drives expansion of antiviral CD8+ T-cells in wild-type mice and following bone marro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5f9ed692fe06c3621299e5a0cdac9ed
https://doi.org/10.1182/blood.v106.11.575.575

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Immunization with Live-Attenuated Listeria Encoding CMV Antigen Induces Extensive Expansion of CMV-Specific CD8+ T-Cells Following HSCT: An Alternative to Adoptive Antiviral Immunotherapy

Autor: William S. Luckett, John D. Roback, Elisabeth Hesse, Thomas W. Dubensky, Christopher D. Hillyer, Martin A. Giedlin, Levan J. Lezhava

Publikováno v: Blood. 104:2129-2129

Background : Recipients of hematopoietic stem cell transplantation (HSCT) can be severely immunocompromised, predisposing to opportunistic infections including cytomegalovirus (CMV). While adoptive transfer of ex vivo expanded donor antiviral T-cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c57ab10a5188befa7c411e2d089d000
https://doi.org/10.1182/blood.v104.11.2129.2129

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Amotosalen-treated donor T cells have polyclonal antigen-specific long-term function without graft-versus-host disease after allogeneic bone marrow transplantation

Autor: Christopher D. Hillyer, John D. Roback, Mohammad S. Hossain, Edmund K. Waller, Levan J. Lezhava

Publikováno v: Biology of Blood and Marrow Transplantation. (3):169-180

We have previously shown that amotosalen HCl (S-59 psoralen)-treated donor splenocytes, which have limited proliferative capacity in vitro, can protect major histocompatibility complex-mismatched bone marrow transplant (BMT) recipients from lethal mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd06344b4b4878f2997edd755ee230d9

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Akademický článek

Transfusion-transmitted cytomegalovirus (CMV) infections in a murine model: characterization of CMV-infected donor mice.

Autor: Roback, John D., Su, Leon, Newman, James L., Saakadze, Natia, Lezhava, Levan J., Hillyer, Christopher D.

Publikováno v: Transfusion; Jun2006, Vol. 46 Issue 6, p889-895, 7p, 1 Diagram, 5 Graphs

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Akademický článek

Photochemical treatment of platelet concentrates with amotosalen hydrochloride and ultraviolet A light inactivates free and latent cytomegalovirus in a murine transfusion model.

Autor: Jordan, Cetherine T., Saakadze, Natia, Newman, James L., Lezhava, Levan J., Maiers, Tanya T., Hillyer, Whitney M., Roback, John D., Hillyer, Christopher D.

Publikováno v: Transfusion; Aug2004, Vol. 44 Issue 8, p1159-1165, 7p

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