Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Lev Sirota"'
Autor:
Sharon E. Frey, Pei Zhang, Frances Wells, Alla Kachko, Lev Sirota, Marian E. Major, Ranjit Ray, Iryna Zubkova
Publikováno v:
Hepatology
Hepatitis C virus (HCV) neutralization occurring at the E2 region 412-426 (EP-I) could be enhanced when antibodies directed specifically to the E2 region 434-446 (EP-II) were removed from serum samples of persistently infected patients and vaccinated
Publikováno v:
Biologicals. 41:111-114
We examined the capability of a mouse immunogenicity assay to detect improper storage of a recombinant protective antigen (rPA)-based anthrax vaccine formulated with an aluminum adjuvant, using ELISA and a toxin neutralization assay (TNA) to measure
Autor:
Juan Arciniega, Esther D. Valerdi-Madrigal, Lev Sirota, Rocío I. Domínguez-Castillo, Juan C. Amador-Molina
Publikováno v:
Vaccine. 34(35)
Anthrax vaccines containing recombinant PA (rPA) as the only antigen face a stability issue: rPA forms aggregates in solution after exposure to temperatures ⩾40°C, thus losing its ability to form lethal toxin (LeTx) with Lethal Factor. To study rP
Autor:
Lev Sirota, Patricia Parreiras, Alicia Jiménez-Alberto, Juan A. Castelán-Vega, Juan Arciniega
Publikováno v:
Biologicals. 39:236-241
Complexities of lethal challenge animal models have prompted the investigation of immunogenicity assays as potency tests of anthrax vaccines. An ELISA was used to measure the antibody response to protective antigen (PA) in mice immunized once with a
Autor:
Jody Manischewitz, Lisa R. King, John Scott, Senta M. Kapnick, Shantha Kodihalli, Hana Golding, Marina Zaitseva, Lev Sirota
Publikováno v:
Journal of Virology. 83:10437-10447
To find an alternative endpoint for the efficacy of antismallpox treatments, bioluminescence was measured in live BALB/c mice following lethal challenge with a recombinant WR vaccinia virus expressing luciferase. Intravenous vaccinia immunoglobulin t
Autor:
Elena Cherkasova, N. I. Romanenkova, Gennady V. Rezapkin, Krasnoproshina Li, Eremeeva Tp, Konstantin Chumakov, Maria L. Yakovenko, N. R. Rozaeva, Olga Ivanova, Vadim I. Agol, Lev Sirota, Ekaterina A. Korotkova
Publikováno v:
Journal of Virology. 79:1062-1070
Sabin strains used in the manufacture of oral polio vaccine (OPV) replicate in the human organism and can give rise to vaccine-derived polioviruses. The increased neurovirulence of vaccine derivatives has been known since the beginning of OPV use, bu
Publikováno v:
Clinical and vaccine immunology : CVI. 18(2)
We report that a toxin neutralization assay (TNA) can detect a decrease in the immunogenicity of anthrax vaccines as a consequence of brief exposure to elevated temperature. This attribute of TNA may help in adopting immunogenicity as a replacement o
Publikováno v:
Vaccine. 27(33)
Complexities of lethal challenge models have prompted the investigation of immunogenicity assays as potency tests of anthrax vaccines. An ELISA and a lethal toxin neutralization assay (TNA) were used to measure antibody response to Protective Antigen
Autor:
Steven A. Rubin, Judy A. Beeler, Susette Audet, Paul A. Rota, William J. Bellini, Li Qi, Bradley J. Sullivan, Lev Sirota, Kathryn M. Carbone
Publikováno v:
The Journal of infectious diseases. 198(4)
Recent mumps outbreaks in older vaccinated populations were caused primarily by genotype G viruses, which are phylogenetically distinct from the genotype A vaccine strains used in the countries affected by the outbreaks. This finding suggests that ge
Autor:
Jody Manischewitz, Clement A. Meseda, Hana Golding, Michael Merchlinsky, Russell Vassell, Lev Sirota, Yong He, Ira Berkower, Carol D. Weiss
Publikováno v:
The Journal of infectious diseases. 196(7)
The smallpox vaccine Dryvax, which consists of replication-competent vaccinia virus, elicits antibodies that play a major role in protection. Several vaccinia proteins generate neutralizing antibodies, but their importance for protection is unknown.