Zobrazeno 1 - 10
of 207
pro vyhledávání: '"Lev S. Tsimring"'
Publikováno v:
Translational Medicine of Aging, Vol 4, Iss , Pp 151-160 (2020)
Aging is a complex, yet pervasive phenomenon in biology. As human cells steadily succumb to the deteriorating effects of aging, so too comes a host of age-related ailments such as neurodegenerative disorders, cardiovascular disease and cancer. Theref
Externí odkaz:
https://doaj.org/article/15f33c91c5894ffb88187e73b51b188c
Autor:
Zhen Zhou, Yuting Liu, Yushen Feng, Stephen Klepin, Lev S. Tsimring, Lorraine Pillus, Jeff Hasty, Nan Hao
Publikováno v:
Science. 380:376-381
Synthetic biology enables the design of gene networks to confer specific biological functions, yet it remains a challenge to rationally engineer a biological trait as complex as longevity. A naturally occurring toggle switch underlies fate decisions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9edd23ea5a6c76bfdc9b5a0b8388320f
https://doi.org/10.1126/science.add7631
https://doi.org/10.1126/science.add7631
Macrophages must respond appropriately to pathogens and other pro-inflammatory stimuli in order to perform their roles in fighting infection. One way in which inflammatory stimuli can vary is in their dynamics – that is, the amplitude and duration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51b79dab3c3f89bc7785888443b6b0e6
https://doi.org/10.1101/2023.05.19.541501
https://doi.org/10.1101/2023.05.19.541501
Autor:
Zhen Zhou, Julie Paxman, Richard O'Laughlin, Yuting Liu, Yang Li, Wanying Tian, Hetian Su, Yanfei Jiang, Shayna E Holness, Elizabeth Stasiowski, Lev S Tsimring, Lorraine Pillus, Jeff Hasty, Nan Hao
Chromatin instability and protein homeostasis (proteostasis) stress are two well-established hallmarks of aging, which have been considered largely independent of each other. Using microfluidics and single-cell imaging approaches, we observed that, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7390565de28c9cee00d7665579630c10
https://escholarship.org/uc/item/96h8k9h8
https://escholarship.org/uc/item/96h8k9h8
Autor:
Zhen Zhou, Julie Paxman, Richard O'Laughlin, Yuting Liu, Yang Li, Wanying Tian, Hetian Su, Yanfei Jiang, Shayna E Holness, Elizabeth Stasiowski, Lev S Tsimring, Lorraine Pillus, Jeff Hasty, Nan Hao
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5af0cacc07463f14d0a9e1f9180db9b
https://doi.org/10.7554/elife.75978.sa2
https://doi.org/10.7554/elife.75978.sa2
Autor:
Arkady Pikovsky, Lev S. Tsimring
Publikováno v:
Mathematical Biosciences. 358:108980
Asymmetric damage segregation (ADS) is ubiquitous among unicellular organisms: After a mother cell divides, its two daughter cells receive sometimes slightly, sometimes strongly different fractions of damaged proteins accumulated in the mother cell.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd01e3c35194b4af48a1ce11ab7d07b
https://doi.org/10.1016/j.mbs.2023.108980
https://doi.org/10.1016/j.mbs.2023.108980
Publikováno v:
Biophysical journal. 121(21)
Cellular responses to the presence of toxic compounds in their environment require prompt expression of the correct levels of the appropriate enzymes, which are typically regulated by transcription factors that control gene expression for the duratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::446d047954a1eeb22a298e72f939f4af
https://pubmed.ncbi.nlm.nih.gov/36168291
https://pubmed.ncbi.nlm.nih.gov/36168291
Publikováno v:
Translational Medicine of Aging, Vol 4, Iss, Pp 151-160 (2020)
Aging is a complex, yet pervasive phenomenon in biology. As human cells steadily succumb to the deteriorating effects of aging, so too comes a host of age-related ailments such as neurodegenerative disorders, cardiovascular disease and cancer. Theref
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f23c02571cdfe7f4cb7cd36ed1bbf271
http://www.sciencedirect.com/science/article/pii/S2468501119300112
http://www.sciencedirect.com/science/article/pii/S2468501119300112
Autor:
Julie Paxman, Zhen Zhou, Richard O’Laughlin, Yang Li, Wanying Tian, Hetian Su, Yanfei Jiang, Shayna E. Holness, Elizabeth Stasiowski, Lev S. Tsimring, Lorraine Pillus, Jeff Hasty, Nan Hao
SummaryChromatin instability and loss of protein homeostasis (proteostasis) are two well-established hallmarks of aging, which have been considered largely independent of each other. Using microfluidics and single-cell imaging approaches, we observed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7050b11a2bb0502d90f5d0428183ac5
https://doi.org/10.1101/2021.12.06.471495
https://doi.org/10.1101/2021.12.06.471495
Autor:
Natalie A Cookson, William H Mather, Tal Danino, Octavio Mondragón‐Palomino, Ruth J Williams, Lev S Tsimring, Jeff Hasty
Publikováno v:
Molecular Systems Biology, Vol 7, Iss 1, Pp 1-9 (2011)
Abstract High‐throughput technologies have led to the generation of complex wiring diagrams as a post‐sequencing paradigm for depicting the interactions between vast and diverse cellular species. While these diagrams are useful for analyzing biol
Externí odkaz:
https://doaj.org/article/7509c9323d874f10a48122a309c2e61e