Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Lev Khmelnitsky"'
Autor:
Shira Warszawski, Aliza Borenstein Katz, Rosalie Lipsh, Lev Khmelnitsky, Gili Ben Nissan, Gabriel Javitt, Orly Dym, Tamar Unger, Orli Knop, Shira Albeck, Ron Diskin, Deborah Fass, Michal Sharon, Sarel J Fleishman
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 10, p e1008382 (2020)
[This corrects the article DOI: 10.1371/journal.pcbi.1007207.].
Externí odkaz:
https://doaj.org/article/34a7c7852e7c4ed68840834016e7017c
Autor:
Shira Warszawski, Aliza Borenstein Katz, Rosalie Lipsh, Lev Khmelnitsky, Gili Ben Nissan, Gabriel Javitt, Orly Dym, Tamar Unger, Orli Knop, Shira Albeck, Ron Diskin, Deborah Fass, Michal Sharon, Sarel J Fleishman
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 8, p e1007207 (2019)
Antibodies developed for research and clinical applications may exhibit suboptimal stability, expressibility, or affinity. Existing optimization strategies focus on surface mutations, whereas natural affinity maturation also introduces mutations in t
Externí odkaz:
https://doaj.org/article/8ac5f6b2550b469daacf44c1a218e827
Publikováno v:
Blood. 140:2835-2843
The von Willebrand factor (VWF) glycoprotein is stored in tubular form in Weibel-Palade bodies (WPBs) before secretion from endothelial cells into the bloodstream. The organization of VWF in the tubules promotes formation of covalently linked VWF pol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60fd10e17071ab52bd72651fe0f17291
https://doi.org/10.1182/blood.2022017153
https://doi.org/10.1182/blood.2022017153
Autor:
Ariel Tennenhouse, Lev Khmelnitsky, Razi Khalaila, Noa Yeshaya, Ashish Noronha, Moshit Lindzen, Emily Makowski, Ira Zaretsky, Yael Fridmann Sirkis, Yael Galon-Wolfenson, Peter M. Tessier, Jakub Abramson, Yosef Yarden, Deborah Fass, Sarel J. Fleishman
Humanization is an essential step in developing animal-derived antibodies into therapeutics, and approximately one third of approved antibodies have been humanized. Conventional humanization approaches graft the complementarity-determining regions (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::035c82beebe5e97b06e0fdd86324b028
https://doi.org/10.1101/2022.08.14.503891
https://doi.org/10.1101/2022.08.14.503891
SUMMARYThe respiratory and intestinal tracts are exposed to physical and biological hazards accompanying the intake of air and food. Likewise, the vasculature is threatened by inflammation and trauma. Mucin glycoproteins and the related von Willebran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13737f4cb612bed55f62fdf4ea95174e
https://doi.org/10.1101/2020.03.08.982447
https://doi.org/10.1101/2020.03.08.982447
Autor:
Deborah Fass, David Morgenstern, Yaakov Levy, Lavi S. Bigman, Lev Khmelnitsky, Ron Diskin, Gabriel Javitt, Tal Ilani, Nadav Elad, Lis Albert
Publikováno v:
Cell
Summary The respiratory and intestinal tracts are exposed to physical and biological hazards accompanying the intake of air and food. Likewise, the vasculature is threatened by inflammation and trauma. Mucin glycoproteins and the related von Willebra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3456e46d584fc79f89ae372f31f879c
https://pubmed.ncbi.nlm.nih.gov/33031746
https://pubmed.ncbi.nlm.nih.gov/33031746