Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Lev G Lis"'
Publikováno v:
International Journal of Mass Spectrometry. 413:163-167
The equilibrium acidity of styrene was measured (ΔH°acid(PhCH CH2) = 390.6 ± 0.5 kcal mol−1) and its deprotonation site was revised from the ortho position on the aromatic ring to the α-hydrogen atom based upon deuterium-labeling studies and ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::483499ace026a139ed6b304270a4882c
https://doi.org/10.1016/j.ijms.2016.03.009
https://doi.org/10.1016/j.ijms.2016.03.009
Autor:
Beverly Norris, Rebecca A. D. Cuellar, Satish Patil, Robert J. Schumacher, Bruce R. Blazar, Lev G Lis, Raj Suryanarayanan, Vadim J. Gurvich, Monique Morgan, Gunda I. Georg
Publikováno v:
Journal of Medicinal Chemistry
A disodium phosphonooxymethyl prodrug of the antitumor agent triptolide was prepared from the natural product in three steps (39% yield) and displayed excellent aqueous solubility at pH 7.4 (61 mg/mL) compared to the natural product (17 μg/mL). The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d70ac155da712a5c54c8738d17c028
https://doi.org/10.1021/acs.jmedchem.5b01329
https://doi.org/10.1021/acs.jmedchem.5b01329
Autor:
Ameya R. Kirtane, Jayanth Panyam, Lev G Lis, Vadim J. Gurvich, Henry L. Wong, Bharath Raja Guru, Gunda I. Georg
Publikováno v:
Molecular Pharmaceutics
Several promising anticancer drug candidates have been sidelined owing to their poor physicochemical properties or unfavorable pharmacokinetics, resulting in high overall cost of drug discovery and development. Use of alternative formulation strategi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::782ffd442e6a1d0d099fe371adcc9c54
https://doi.org/10.1021/acs.molpharmaceut.5b00173
https://doi.org/10.1021/acs.molpharmaceut.5b00173
Autor:
Victor M.F. Morais, Joel F. Liebman, Lev G Lis, Margarida S. Miranda, Steven R. Kass, M. Agostinha R. Matos, Alireza Fattahi
Publikováno v:
International Journal of Mass Spectrometry. 378:175-179
The heat of hydrogenation of indenone was measured via two partially independent thermodynamic cycles by carrying out energetic measurements (i.e., electron affinities, proton affinities and ionization potentials) on both negative and positive ions (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a386307c755055dad2a20e3ec12912c6
https://doi.org/10.1016/j.ijms.2014.07.042
https://doi.org/10.1016/j.ijms.2014.07.042
Publikováno v:
The AAPS Journal. 16:577-585
Current treatments for seizure emergencies, such as status epilepticus, include intravenous or rectal administration of benzodiazepines. While intranasal delivery of these drugs is desirable, the small volume of the nasal cavity and low drug solubili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be7abb40f6096aaa2c8db20040ed2963
https://doi.org/10.1208/s12248-014-9596-5
https://doi.org/10.1208/s12248-014-9596-5
Autor:
James Fisher, Arkadiusz Z. Dudek, Mark N. Kirstein, Brent W. Williams, Vadim J. Gurvich, Jatinder K. Lamba, Robert A. Kratzke, Edward W Greeno, Richard C. Brundage, Keith M. Skubitz, Amit Khatri, Lev G Lis
Publikováno v:
British Journal of Cancer
Background: Gemcitabine is used for the treatment of several solid tumours and exhibits high inter-individual pharmacokinetic variability. In this study, we explore possible predictive covariates on drug and metabolite disposition. Methods: Forty pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c784c8332ae81e7cbb26c446f17dc7fa
http://europepmc.org/articles/PMC3899768
http://europepmc.org/articles/PMC3899768
Publikováno v:
The Journal of organic chemistry. 81(19)
The α-C–H bond dissociation energy (BDE) of phenylcyclopropane (1) was experimentally determined using Hess’ law. An equilibrium acidity determination of 1 afforded ΔH°acid = 389.1 ± 0.8 kcal mol–1, and isotopic labeling established that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a728ed351578d3af74ea9661ae2e544
https://pubmed.ncbi.nlm.nih.gov/27598540
https://pubmed.ncbi.nlm.nih.gov/27598540
Synthesis and Biological Evaluation of a Biotinylated Paclitaxel with an Extra-Long Chain Spacer Arm
Publikováno v:
ACS Medicinal Chemistry Letters. 3:745-748
A biotinylated paclitaxel derivative with an extra-long-chain (LC-LC-Biotin) spacer arm was synthesized using an improved synthetic reaction sequence. The biotinylated paclitaxel analogue retained excellent microtubule stabilizing activity in vitro.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed6010a37c192c2ba633b51cef75e61
https://doi.org/10.1021/ml300149z
https://doi.org/10.1021/ml300149z
Publikováno v:
The Journal of Organic Chemistry. 77:1909-1914
Bridgehead C-H bond dissociation enthalpies of 105.7 ± 2.0, 102.9 ± 1.7, and 102.4 ± 1.9 kcal mol(-1) for bicyclo[2.2.1]heptane, bicyclo[2.2.2]octane, and adamantane, respectively, were determined in the gas phase by making use of a thermodynamic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7103735c0c0d6554b691b439a8c30ac8
https://doi.org/10.1021/jo202519w
https://doi.org/10.1021/jo202519w
Publikováno v:
ChemMedChem. 6:457-464
Recent evidence has shown that the gemcitabine metabolite, dFdU, is pharmacologically active. Though less potent, dFdU has a longer half-life and could potentiate or antagonize the activity of gemcitabine. Hence, studies were undertaken to evaluate t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcccf815483b85912a85e39368444e03
https://doi.org/10.1002/cmdc.201000447
https://doi.org/10.1002/cmdc.201000447