Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Leutz Buon"'
Autor:
Arghya Ray, Yan Song, Ting Du, Leutz Buon, Yu-Tzu Tai, Dharminder Chauhan, Kenneth C. Anderson
Publikováno v:
Blood Cancer Journal, Vol 12, Iss 4, Pp 1-9 (2022)
Abstract Interaction of plasmacytoid dendritic cells (pDCs) with multiple myeloma (MM) cells, T- or NK-effector cells in the bone marrow (BM) microenvironment induces tumor cell growth, as well as inhibits innate and adaptive immune responses. Defini
Externí odkaz:
https://doaj.org/article/611fa179f07b433aa1412b229508b4e1
Autor:
Srikanth Talluri, Mehmet K. Samur, Leutz Buon, Subodh Kumar, Lakshmi B. Potluri, Jialan Shi, Rao H. Prabhala, Masood A. Shammas, Nikhil C. Munshi
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 10, Pp 1-11 (2021)
Abstract Multiple myeloma (MM) is a heterogeneous disease characterized by significant genomic instability. Recently, a causal role for the AID/APOBEC deaminases in inducing somatic mutations in myeloma has been reported. We have identified APOBEC/AI
Externí odkaz:
https://doaj.org/article/d13895ee298b46c692921d6655cf5d13
Autor:
Subodh Kumar, Leutz Buon, Srikanth Talluri, Marco Roncador, Chengcheng Liao, Jiangning Zhao, Jialan Shi, Chandraditya Chakraborty, Gabriel Gonzalez, Yu-Tzu Tai, Rao Prabhala, Mehmet K. Samur, Nikhil C. Munshi, Masood A. Shammas
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Subodh Kumar et al. identify a gene signature correlated with genomic instability and poor survival in esophageal adenocarcinoma (EAC), using a combination of integrative genomic analysis of patient data and laboratory validation in cell line models
Externí odkaz:
https://doaj.org/article/6f113318075d4e0bb3590bebd59eb8e1
Autor:
David A. Alagpulinsa, Subodh Kumar, Srikanth Talluri, Purushothama Nanjappa, Leutz Buon, Chandraditya Chakraborty, Mehmet K. Samur, Raphael Szalat, Masood A. Shammas, Nikhil C. Munshi
Publikováno v:
Blood Advances, Vol 3, Iss 23, Pp 3968-3972 (2019)
Externí odkaz:
https://doaj.org/article/68f9b9f0a81b4636ba4f852e7becd60b
Autor:
Subodh Kumar, Jiangning Zhao, Srikanth Talluri, Leutz Buon, Shidai Mu, Bhavani Potluri, Chengcheng Liao, Jialan Shi, Chandraditya Chakraborty, Gabriel B. Gonzalez, Yu-Tzu Tai, Jaymin Patel, Jagannath Pal, Hiroshi Mashimo, Mehmet K. Samur, Nikhil C. Munshi, Masood A. Shammas
Publikováno v:
Gastroenterology.
Autor:
Constantine S. Mitsiades, Andrew L. Kung, Steven P. Treon, Kenneth C. Anderson, Paul G. Richardson, Peter G. Smith, Jie Yu, Val Monrose, Zachary R. Hunter, Leutz Buon, Jake E. Delmore, Hannah M. Jacobs, Douglas W. McMillin
The NEDD8-activating enzyme is upstream of the 20S proteasome in the ubiquitin/proteasome pathway and catalyzes the first step in the neddylation pathway. NEDD8 modification of cullins is required for ubiquitination of cullin-ring ligases that regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5809ba0a491ec39cb9debc8d3ccb5b25
https://doi.org/10.1158/1535-7163.c.6536155.v1
https://doi.org/10.1158/1535-7163.c.6536155.v1
Autor:
Constantine S. Mitsiades, Andrew L. Kung, Steven P. Treon, Kenneth C. Anderson, Paul G. Richardson, Peter G. Smith, Jie Yu, Val Monrose, Zachary R. Hunter, Leutz Buon, Jake E. Delmore, Hannah M. Jacobs, Douglas W. McMillin
PDF file - 116K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697722da78719ccaee9974a21f2db782
https://doi.org/10.1158/1535-7163.22499470.v1
https://doi.org/10.1158/1535-7163.22499470.v1
Autor:
Nicholas Mitsiades, Kenneth C. Anderson, Constantine S. Mitsiades, Paul G. Richardson, Peter O'Gorman, Martin Clynes, Leutz Buon, Teru Hideshima, Dharminder Chauhan, Nikhil C. Munshi, Noopur S. Raje, Emily Daskalaki, Elpida Charalambous, Douglas W. McMillin, Vassiliki Kotoula, Patrick J. Hayden, Melissa G. Ooi
Supplementary Data from Interactions of the Hdm2/p53 and Proteasome Pathways May Enhance the Antitumor Activity of Bortezomib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a845c66dc7589f8466201841a601261
https://doi.org/10.1158/1078-0432.22439989
https://doi.org/10.1158/1078-0432.22439989
Autor:
Nicholas Mitsiades, Kenneth C. Anderson, Constantine S. Mitsiades, Paul G. Richardson, Peter O'Gorman, Martin Clynes, Leutz Buon, Teru Hideshima, Dharminder Chauhan, Nikhil C. Munshi, Noopur S. Raje, Emily Daskalaki, Elpida Charalambous, Douglas W. McMillin, Vassiliki Kotoula, Patrick J. Hayden, Melissa G. Ooi
Purpose: p53 is inactivated in many human malignancies through missense mutations or overexpression of the human homologue of Mdm2 (Hdm2), an E3 ubiquitin ligase that ubiquitinates p53, thereby promoting its proteasomal degradation. The cis-imidazoli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::728045ed524eeea6ccdefabb43cb52bf
https://doi.org/10.1158/1078-0432.c.6517366.v1
https://doi.org/10.1158/1078-0432.c.6517366.v1
Autor:
Chengcheng Liao, Srikanth Talluri, Jiangning Zhao, Shidai Mu, Subodh Kumar, Jialan Shi, Leutz Buon, Nikhil C. Munshi, Masood A. Shammas
Publikováno v:
Cancers; Volume 14; Issue 22; Pages: 5697
Background: In normal cells, homologous recombination (HR) is tightly regulated and plays an important role in the maintenance of genomic integrity and stability through precise repair of DNA damage. RAD51 is a recombinase that mediates homologous ba