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Stearoyl-CoA desaturase regulates sorafenib resistance via modulation of ER stress-induced differentiation.

Autor: Ma MKF; State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong., Lau EYT; State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong; Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong., Leung DHW; State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong., Lo J; State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong., Ho NPY; State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong., Cheng LKW; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong., Ma S; State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong., Lin CH; Centre for Genomic Science, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong., Copland JA; Department of Cancer Biology, Mayo Clinic Florida, Jacksonville, United States., Ding J; Eastern Hepatobiliary Surgery Hospital, The International Cooperation Laboratory on Signal Transduction, China., Lo RCL; State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong., Ng IOL; State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong. Electronic address: iolng@hku.hk., Lee TKW; State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong; State Key Laboratory of Chirosciences, The Hong Kong Polytechnic University, Hong Kong. Electronic address: terence.kw.lee@polyu.edu.hk.

Publikováno v: Journal of hepatology [J Hepatol] 2017 Nov; Vol. 67 (5), pp. 979-990. Date of Electronic Publication: 2017 Jun 22.