Alterations in lipid metabolism gene expression and abnormal lipid accumulation in fibroblast explants from giant axonal neuropathy patients

Autor: Goryunov Dmitry, Shu Chang, Pang Yinghua, Leung Conrad L, Liem Ronald KH

Publikováno v: BMC Genetics, Vol 8, Iss 1, p 6 (2007)

Abstract Background Giant axonal neuropathy (GAN) is a hereditary neurological disorder that affects both central and peripheral nerves. The main pathological hallmark of the disease is abnormal accumulations of intermediate filaments (IFs) in giant

Externí odkaz: https://doaj.org/article/948375dcbb87414fa168b9125f6759b6

Protocol to track the biosynthesis of cholesterol in cultured HCC cells using ¹³ C compound-specific stable isotopic tracers.

Autor: Cybulski JD; School of Biological Sciences, Faculty of Science, The University of Hong Kong, Hong Kong, Hong Kong SAR; Smithsonian Tropical Research Institute, Balboa, Republic of Panama. Electronic address: cybulski.j@gmail.com., Leung KS; Smithsonian Tropical Research Institute, Balboa, Republic of Panama., Leung CON; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, Hong Kong SAR., Baker DM; Smithsonian Tropical Research Institute, Balboa, Republic of Panama. Electronic address: dmbaker@hku.hk., Lee TKW; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, Hong Kong SAR; State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hong Kong, Hong Kong SAR. Electronic address: terence.kw.lee@polyu.edu.hk.

Publikováno v: STAR protocols [STAR Protoc] 2023 Sep 15; Vol. 4 (3), pp. 102506. Date of Electronic Publication: 2023 Aug 17.

Caspase-3-Induced Activation of SREBP2 Drives Drug Resistance via Promotion of Cholesterol Biosynthesis in Hepatocellular Carcinoma.

Autor: Mok EHK; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong., Leung CON; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong., Zhou L; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong., Lei MML; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong., Leung HW; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong., Tong M; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong., Wong TL; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong., Lau EYT; Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong., Ng IOL; Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong.; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong., Ding J; The International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Shanghai, China., Yun JP; Department of Pathology, Sun Yat Sen University Cancer Center, Guangzhou, China., Yu J; Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong., Zhu HL; School of Public Health, Sun Yat Sen University, Guangzhou, China., Lin CH; Centre for PanorOmic Science, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong., Lindholm D; Medicum, Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland., Leung KS; School of Biological Sciences, Faculty of Science, The University of Hong Kong, Hong Kong., Cybulski JD; School of Biological Sciences, Faculty of Science, The University of Hong Kong, Hong Kong., Baker DM; School of Biological Sciences, Faculty of Science, The University of Hong Kong, Hong Kong., Ma S; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong., Lee TKW; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong.; State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hong Kong.

Publikováno v: Cancer research [Cancer Res] 2022 Sep 02; Vol. 82 (17), pp. 3102-3115.

EPHB2 Activates β-Catenin to Enhance Cancer Stem Cell Properties and Drive Sorafenib Resistance in Hepatocellular Carcinoma.

Autor: Leung HW; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, P.R. China., Leung CON; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, P.R. China., Lau EY; Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, P.R. China., Chung KPS; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, P.R. China., Mok EH; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, P.R. China., Lei MML; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, P.R. China., Leung RWH; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, P.R. China., Tong M; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, P.R. China., Keng VW; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, P.R. China., Ma C; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, P.R. China., Zhao Q; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, P.R. China., Ng IOL; Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, P.R. China.; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong, P.R. China., Ma S; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, P.R. China.; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong, P.R. China., Lee TK; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, P.R. China. terence.kw.lee@polyu.edu.hk.; State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hong Kong, P.R. China.

Publikováno v: Cancer research [Cancer Res] 2021 Jun 15; Vol. 81 (12), pp. 3229-3240. Date of Electronic Publication: 2021 Apr 26.

The interplay of UBE2T and Mule in regulating Wnt/β-catenin activation to promote hepatocellular carcinoma progression.

Autor: Ho NPY; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, Hong Kong., Leung CON; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, Hong Kong., Wong TL; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong., Lau EYT; Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, Hong Kong., Lei MML; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, Hong Kong., Mok EHK; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, Hong Kong., Leung HW; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, Hong Kong., Tong M; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong., Ng IOL; Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, Hong Kong.; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong, Hong Kong., Yun JP; Department of Pathology, Sun Yat Sen University Cancer Center, Guangzhou, China., Ma S; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong, Hong Kong., Lee TKW; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, Hong Kong. terence.kw.lee@polyu.edu.hk.; State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hong Kong, Hong Kong. terence.kw.lee@polyu.edu.hk.

Publikováno v: Cell death & disease [Cell Death Dis] 2021 Feb 01; Vol. 12 (2), pp. 148. Date of Electronic Publication: 2021 Feb 01.