Synthesis, binding and cellular uptake properties of oligodeoxynucleotides containing cationic bicyclo-thymidine residues

Autor: Lietard, Jory, Ittig, Damian, Leumann, Christian J.

Publikováno v: In Bioorganic & Medicinal Chemistry 2011 19(19):5869-5875

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A fluorescence-quencher pair for DNA hybridization studies based on hydrophobic base surrogates

Autor: Stoop, Matthias, Zahn, Alain, Leumann, Christian J.

Publikováno v: In Tetrahedron 2007 63(17):3440-3449

Synthesis of functionalized biphenyl- C-nucleosides and their incorporation into oligodeoxynucleotides

Autor: Zahn, Alain, Leumann, Christian J.

Publikováno v: In Bioorganic & Medicinal Chemistry 2006 14(18):6174-6188

Efficient SMN Rescue following Subcutaneous Tricyclo-DNA Antisense Oligonucleotide Treatment

Autor: Robin, Valérie, Griffith, Graziella, Carter, John-Paul L., Leumann, Christian J., Garcia, Luis, Goyenvalle, Aurélie

Publikováno v: Molecular Therapy. Nucleic Acids
Molecular Therapy-Nucleic Acids
Molecular Therapy-Nucleic Acids, Elsevier, 2017, 7, pp.81-89. ⟨10.1016/j.omtn.2017.02.009⟩
Molecular Therapy-Nucleic Acids, 2017, 7, pp.81-89. ⟨10.1016/j.omtn.2017.02.009⟩
Robin, Valérie; Griffith, Graziella; Carter, John-Paul L.; Leumann, Christian; Garcia, Luis; Goyenvalle, Aurélie (2017). Efficient SMN Rescue following Subcutaneous Tricyclo-DNA Antisense Oligonucleotide Treatment. Molecular Therapy-Nucleic Acids, 7, pp. 81-89. Nature Publishing Group 10.1016/j.omtn.2017.02.009
Molecular Therapy: Nucleic Acids, Vol 7, Iss C, Pp 81-89 (2017)

Spinal muscular atrophy (SMA) is a recessive disease caused by mutations in the SMN1 gene, which encodes the protein survival motor neuron (SMN), whose absence dramatically affects the survival of motor neurons. In humans, the severity of the disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6fb13b448567b77f90eee347f27db7a4
http://europepmc.org/articles/PMC5415958