Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Leukotriene D4 receptor"'
Publikováno v:
Iranian Journal of Allergy, Asthma and Immunology, Vol 20, Iss 4 (2021)
Coronavirus disease 2019 (COVID-19) is an emerging worldwide issue, that has affected a large number of people around the world. So far, many studies have aimed to develop a therapeutic approach against COVID-19. Montelukast (MK) is a safe asthma con
Externí odkaz:
https://doaj.org/article/312448adc9bd420fad7e1412b904e6ab
Publikováno v:
Iranian Journal of Allergy, Asthma and Immunology, Vol 20, Iss 4 (2021)
Coronavirus disease 2019 (COVID-19) is an emerging worldwide issue, that has affected a large number of people around the world. So far, many studies have aimed to develop a therapeutic approach against COVID-19. Montelukast (MK) is a safe asthma con
Akademický článek
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Autor:
Yoshinori Okamoto, Souichirou Kawazoe, Ryo Naito, Hirokazu Kubota, Masaki Yokota, Minoru Okada, Makoto Takeuchi, Takeshi Oriyama, Shigeru Ieda
Publikováno v:
Bulletin of the Chemical Society of Japan. 87:127-140
Both (+)- and (−)-4-{[(2-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)-vinyl]phenyl}ethyl)thio]methyl}benzoic acid (1), Thromboxane A2 and Leukotriene D4 receptor dual antagonist ...
Publikováno v:
Proceedings of The 20th International Electronic Conference on Synthetic Organic Chemistry.
Montelukast 1 is a famous drug demonstrated for the chronic and prophylaxis therapy of asthma. It behaves as a selective antagonist of the leukotriene D4 receptor which causes the decrease of broncho constriction and eventuates in less inflammation.
Publikováno v:
Spectroscopy Letters. 36:407-418
The complete 1H and 13C NMR assignment and stereochemical elucidation of four norbornene derivatives (1–4) are presented. These derivatives were obtained by an asymmetric Diels–Alder reaction of a chiral dienophile, from D‐glucose, as leukotrie
Autor:
Shigeru Ieda, Masaki Yokota, Yoshinori Okamoto, Takeshi Oriyama, Hirokazu Kubota, Minoru Okada, Souichirou Kawazoe, Ryo Naito, Makoto Takeuchi
Publikováno v:
ChemInform. 45
Both (+)- and (−)-4-{[(2-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)-vinyl]phenyl}ethyl)thio]methyl}benzoic acid (1), Thromboxane A2 and Leukotriene D4 receptor dual antagonist ...
Autor:
Ayako Tani, Takashi Aikou, Misako Haraguchi, Zhe-Sheng Chen, Tatsuhiko Furukawa, Yuji Takebayashi, Shin-ichi Akiyama, Tomoyuki Sumizawa, Kazutaka Yamada, Shuichi Nagayama, Kiyoshi Niwa, Masaki Kitazono
Publikováno v:
Cancer Letters. 130:175-182
The leukotriene D4 (LTD4) receptor antagonist, 4-oxo-8-[p-(4-phenylbutyloxy)benzoylamino]-2-(tetrazol-5-yl) -4H-1-benzopyran hemihydrate (ONO-1078) is used for the treatment of allergic asthma and other immediate hypersensitivity diseases. We examine
Autor:
C. Rochette, Robert Zamboni, Anthony W. Ford-Hutchinson, Claude Dufresne, Marc Labelle, Deborah Slipetz, C. S. Mcfarlane, Thomas R. Jones, Yves Gareau, Lau Cheuk-Kun, Robert N. Young, L. Charette, Kathleen M. Metters, M. McAuliffe, Nicole Sawyer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1615-1620
Replacement of the quinoline pharmacophore of verlukast by alkylthiazoles and benzothiazoles has lead to the discovery of a new series of potent and orally active LTD4 receptor antagonists. The synthesis and structure activity relationships of this s
Autor:
T. R. Jones, M. Labelle, M. Belley, E. Champion, L. Charette, J. Evans, A. W. Ford-Hutchinson, J. -Y. Gauthier, A. Lord, P. Masson, M. McAuliffe, C. S. McFarlane, K. M. Metters, C. Pickett, H. Piechuta, C. Rochette, I. W. Rodger, N. Sawyer, R. N. Yoyng, R. Zamboni, W. M. Abraham
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 73:191-201
Montelukast sodium (Singulair™), also known as MK-0476 (1-(((1(R)-(3-(2-(7-chloro-2-quinolinyl)-(E)-ethenyl)phenyl)(3-2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane) acetic acid sodium salt, is a potent and selective inhibitor of