The mitochondrial antioxidant SS-31 increases SIRT1 levels and ameliorates inflammation, oxidative stress and leukocyte-endothelium interactions in type 2 diabetes

Autor: Irene Escribano-Lopez, Noelia Diaz-Morales, Francesca Iannantuoni, Sandra Lopez-Domenech, Aranzazu M de Marañon, Zaida Abad-Jimenez, Celia Bañuls, Susana Rovira-Llopis, Jose R Herance, Milagros Rocha, Victor M Victor

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)

Abstract There is growing focus on mitochondrial impairment and cardiovascular diseases (CVD) in type 2 diabetes (T2D), and the development of novel therapeutic strategies in this context. It is unknown whether mitochondrial-targeting antioxidants su

Externí odkaz: https://doaj.org/article/8e519efa5e8d480d87d2a3592d56800e

The mitochondrial antioxidant SS-31 increases SIRT1 levels and ameliorates inflammation, oxidative stress and leukocyte-endothelium interactions in type 2 diabetes

Autor: Noelia Diaz-Morales, Sandra López-Domènech, Francesca Iannantuoni, Irene Escribano-Lopez, Celia Bañuls, Susana Rovira-Llopis, Zaida Abad-Jiménez, José Raúl Herance, Milagros Rocha, Victor M. Victor, Aranzazu M. de Marañón

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports

There is growing focus on mitochondrial impairment and cardiovascular diseases (CVD) in type 2 diabetes (T2D), and the development of novel therapeutic strategies in this context. It is unknown whether mitochondrial-targeting antioxidants such as SS-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::846357e12a0aead7671638f0cfc1841b
https://doaj.org/article/8e519efa5e8d480d87d2a3592d56800e

Effects of different peep levels on mesenteric leukocyte-endothelial interactions in rats during mechanical ventilation

Autor: Rogério Pazetti, Naomi Kondo Nakagawa, Paulina Sannomiya, Priscila Aikawa, Thais Mauad, Maria Aparecida Oliveira, Sandra Helena Poliselli Farsky

Publikováno v: Clinics, Vol 64, Iss 5, Pp 443-450 (2009)
Clinics, Volume: 64, Issue: 5, Pages: 443-450, Published: MAY 2009
Clinics (Sao Paulo, Brazil)
Clinics; v. 64 n. 5 (2009); 443-450
Clinics; Vol. 64 Núm. 5 (2009); 443-450
Clinics; Vol. 64 No. 5 (2009); 443-450
Clinics
Universidade de São Paulo (USP)
instacron:USP

INTRODUCTION: Mechanical ventilation with positive end expiratory pressure (PEEP) improves oxygenation and treats acute pulmonary failure. However, increased intrathoracic pressure may cause regional blood flow alterations that may contribute to mese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88bf718a2c1442c1507fc4d8e85ea6d0
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322009000500012

Mechanotransduction at the basis of endothelial barrier function

Autor: Danielle Gulino-Debrac

Publikováno v: Tissue Barriers

Destabilization of cell-cell contacts involved in the maintenance of endothelial barrier function can lead to increased endothelial permeability. This increase in endothelial permeability results in an anarchical movement of fluid, solutes and cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b51fa9a263a57ad6da4a8a89d05b3c2e
https://pubmed.ncbi.nlm.nih.gov/24665386

Estudo dos efeitos da solução salina hipertônica e do Ringer lactato sobre a resposta da microcirculação mesentérica e a translocação bacteriana em modelo de obstrução intestinal e isquemia em ratos

Autor: Fernando Luiz Zanoni

Publikováno v: Biblioteca Digital de Teses e Dissertações da USPUniversidade de São PauloUSP.

INTRODUÇÃO: Estudos demonstram que a solução salina hipertônica melhora a hemodinâmica, a microcirculação e modula o sistema imune, atenuando a resposta inflamatória associada ao choque e trauma. Este estudo tem por objetivo avaliar e compar

Externí odkaz: http://www.teses.usp.br/teses/disponiveis/5/5152/tde-27092010-152952/