Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Leukocyte adhesion deficiency-1"'
Autor:
Baomei Wang, Niki M. Moutsopoulos, Tetsuhiro Kajikawa, Xiaofei Li, Hui Wang, George Hajishengallis, Triantafyllos Chavakis
Publikováno v:
J Leukoc Biol
β2 Integrins mediate neutrophil-endothelial adhesion and recruitment of neutrophils to sites of inflammation. The diminished expression of β2 integrins in patients with mutations in the ITGB2 (CD18) gene (leukocyte adhesion deficiency-Type 1; LAD1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::771341217477f8c0e0a27a5925a80994
https://doi.org/10.1002/jlb.5hi0420-648r
https://doi.org/10.1002/jlb.5hi0420-648r
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 4, p 1402 (2020)
International Journal of Molecular Sciences, Vol 21, Iss 4, p 1402 (2020)
β2 integrins are heterodimeric surface receptors composed of a variable α (CD11a-CD11d) and a constant β (CD18) subunit and are specifically expressed by leukocytes. The α subunit defines the individual functional properties of the corresponding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fbea1efca25f5fdbffac3244e27ca8d
https://doi.org/10.3390/ijms21041402
https://doi.org/10.3390/ijms21041402
Leukocyte adhesion deficiency 1 (LAD-1) is caused by defects in the β2 integrin subunit. We studied 18 missense mutations, 14 of which fail to support the surface expression of the β2 integrins. Integrins with the β2-G150D mutation fail to bind li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf5445867b6d42648766bb9a3a3f580
http://hdl.handle.net/10220/25195
http://hdl.handle.net/10220/25195
Publikováno v:
Gastroenterology. 121:958-964
Leukocyte adhesion deficiency 1 (LAD-1) is characterized by absent or dysfunctional beta2 integrin (CD18), leading to defective chemotaxis, adherence, phagocytosis, and bacterial killing. Colitis, except for rare intestinal necrotizing events, is not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c1394fb12fbc16d450e22608ad2d42b
https://doi.org/10.1053/gast.2001.28022
https://doi.org/10.1053/gast.2001.28022
Publikováno v:
Cell Motility and the Cytoskeleton. 46:183-189
The β2 integrins are known to be important in the motile function of leukocytes in general and in the adhesive response to inflammatory stimuli in particular. In the current study, under direct microscopic observation with concomitant time-lapse vid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dccf9c6ee7b380bb7eff91c910d09f59
https://doi.org/10.1002/1097-0169(200007)46:3<183::aid-cm3>3.0.co
https://doi.org/10.1002/1097-0169(200007)46:3<183::aid-cm3>3.0.co
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1500(1):70-76
Neutrophils isolated from a child with severe leukocyte adhesion deficiency 1 (LAD1) had a complete absence of expression of the CD11/CD18 β2 integrin family of adhesion molecules, and were shown to be deficient in the in vitro adhesion and migratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::092fc9b3876ed0d3da25549efcddb144
Autor:
Sona Chowdhary, Mohitesh Kumar
Publikováno v:
Indian Journal of Child Health. :153-154
Leukocyte adhesion deficiency 1 (LAD-1) is a rare autosomal recessive disorder of leukocyte function due to integrin deficiency. It is characterized by recurrent bacterial and fungal infections and depressed inflammatory responses despite striking bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::613a2f0963e9811f911e8468a94504ed
https://doi.org/10.32677/ijch.2014.v01.i03.014
https://doi.org/10.32677/ijch.2014.v01.i03.014
Autor:
Ester Rosenthal, Atar Lev, Baruch Wolach, Eran Eyal, Gideon Rechavi, Ninette Amariglio, Ronit Gavrieli, Ephraim Gazit, Amos J. Simon, Raz Somech
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 11, p e13659 (2010)
PLoS ONE, Vol 5, Iss 11, p e13659 (2010)
BackgroundLeukocyte adhesion deficiency 1 (LAD1) is an inherited disorder of neutrophil function. Nonsense mutations in the affected CD18 (ITB2) gene have rarely been described. In other genes containing such mutations, treatments with aminoglycoside
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c11bcd6a3a41908d14ac5627e8e1b49
http://europepmc.org/articles/PMC2982813
http://europepmc.org/articles/PMC2982813
Publikováno v:
Indian Journal of Dermatology, Vol 58, Iss 2, Pp 158-158 (2013)
Indian Journal of Dermatology
Indian Journal of Dermatology
Leukocyte adhesion deficiency 1 (LAD-1) is a rare autosomal recessive disorder of leukocyte function. LAD-1 affects about 1 per 10 million individuals and is characterized by recurrent bacterial and fungal infections and depressed inflammatory respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622b9346e6a78905e8933d9cb365d7b5
http://www.e-ijd.org/article.asp?issn=0019-5154
http://www.e-ijd.org/article.asp?issn=0019-5154
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