Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Leukemia & Proliferative Disorders of Hematic Cells"'
Publikováno v:
F1000Research, Vol 6 (2017)
Owing to the rarity of peripheral T-cell lymphoma (PTCL) and the heterogeneity of subtypes, there are no compelling data to guide the therapeutic approaches for such patients. Over the years, there have been remarkable advances in molecular subtyping
Externí odkaz:
https://doaj.org/article/609f508c93d546508de0c0058d3fdf51
Autor:
Florence Rufflé, Jerome Audoux, Anthony Boureux, Sacha Beaumeunier, Jean-Baptiste Gaillard, Elias Bou Samra, Andre Megarbane, Bruno Cassinat, Christine Chomienne, Ronnie Alves, Sebastien Riquier, Nicolas Gilbert, Jean-Marc Lemaitre, Delphine Bacq-Daian, Anne Laure Bougé, Nicolas Philippe, Therese Commes
Publikováno v:
F1000Research, Vol 6 (2017)
Background: High-throughput next generation sequencing (NGS) technologies enable the detection of biomarkers used for tumor classification, disease monitoring and cancer therapy. Whole-transcriptome analysis using RNA-seq is important, not only as a
Externí odkaz:
https://doaj.org/article/6830ab11a0e74f8ea902dcb6f6467b31
Autor:
Karen Bride, David Teachey
Publikováno v:
F1000Research, Vol 6 (2017)
Autoimmune lymphoproliferative syndrome (ALPS) is an inherited syndrome characterized by abnormal lymphocyte survival caused by failure of apoptotic mechanisms to maintain lymphocyte homeostasis. This failure leads to the clinical manifestations of n
Externí odkaz:
https://doaj.org/article/453545247a7b4ff88d39829060600c27
Autor:
Prithviraj Bose, Varsha Gandhi
Publikováno v:
F1000Research, Vol 6 (2017)
The last several years have witnessed a paradigm shift in the management of patients with chronic lymphocytic leukemia (CLL). The course of this very heterogeneous disease, traditionally treated with chemotherapeutic agents usually in combination wit
Externí odkaz:
https://doaj.org/article/a24cc13720434b4d875d54c33ec51d6a
Autor:
Karen Ballen
Publikováno v:
F1000Research, Vol 6 (2017)
Allogeneic hematopoietic cell transplant is a curative procedure for many patients with leukemia, lymphoma, myelodysplasia, myeloproliferative neoplasms, and genetic disorders. Umbilical cord blood transplantation is a graft source for patients who d
Externí odkaz:
https://doaj.org/article/71e84f0a8a524bfa926bf0948ac2fe0b
Autor:
Chin-Hin Ng, Wee-Joo Chng
Publikováno v:
F1000Research, Vol 6 (2017)
Acute promyelocytic leukaemia (APML) is a subtype of leukaemia arising from a distinct reciprocal translocation involving chromosomes 15 and 17, which results in the PML-RARA fusion gene. Over the past three decades, APML has been transformed from a
Externí odkaz:
https://doaj.org/article/91c1bb2e68724b7689aec1421b3f8d1c
Autor:
Maxim Norkin, John R Wingard
Publikováno v:
F1000Research, Vol 6 (2017)
Hematopoietic cell transplantation (HCT), once used as a last-resort therapy, is now considered a lifesaving procedure for thousands of patients with life-threatening diseases worldwide and is frequently used early in the course of treatment for dise
Externí odkaz:
https://doaj.org/article/dff98ab0fbdc4ebfa5445a6d8d9bf47b
Autor:
Effie W. Petersdorf
Publikováno v:
F1000Research, Vol 6 (2017)
Graft-versus-host disease (GVHD) remains a significant potentially life-threatening complication of allogeneic hematopoietic cell transplantation (HCT). Since the discovery of the human leukocyte antigen (HLA) system over 50 years ago, significant ad
Externí odkaz:
https://doaj.org/article/daaf273c92ee41fea82b84ff1459ae24
Publikováno v:
F1000Research, Vol 5 (2016)
The BCL2-selective BH3 mimetic venetoclax was recently approved for the treatment of relapsed, chromosome 17p-deleted chronic lymphocytic leukemia (CLL) and is undergoing extensive testing, alone and in combination, in lymphomas, acute leukemias, and
Externí odkaz:
https://doaj.org/article/82afa4c14b1641aba5f3ca3068b3ba7b
Autor:
Jan Starý, Ondřej Hrušák
Publikováno v:
F1000Research, Vol 5 (2016)
Acute lymphoblastic leukemia (ALL) is the most common malignancy in childhood. Despite enormous improvement of prognosis during the last half century, ALL remains a major cause of childhood cancer-related mortality. During the past decade, whole geno
Externí odkaz:
https://doaj.org/article/1e3ddd56b5d44d9f97de1d99a6199df0