Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Leu‐Fen H. Lin"'
Publikováno v:
Journal of neurochemistry. 89(6)
A small organic molecule (CUR-162590) that selectively enhances survival of midbrain dopaminergic neurons was identified by screening small molecule compound libraries. In embryonic midbrain cultures, CUR-162590 increased dopamine uptake and the numb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a9d6c72ae09b517a6463e2ed4978fdd
https://pubmed.ncbi.nlm.nih.gov/15189341
https://pubmed.ncbi.nlm.nih.gov/15189341
Autor:
Ronald W. Oppenheim, Leu-Fen H. Lin, Siwei Wang, Albert C. Lo, Ann L. Newsome, Lucien J. Houenou, James E. Johnson, Linxi Li, David Prevette
Publikováno v:
Nature. 373:344-346
DURING normal development of the vertebrate nervous system, large numbers of neurons in the central and peripheral nervous system undergo naturally occurring cell death1. For example, about half of all spinal motor neurons die over a period of a few
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5af93daeb64dd543e8fffb9376c1128
https://doi.org/10.1038/373344a0
https://doi.org/10.1038/373344a0
Publikováno v:
Science. 260:1130-1132
A potent neurotrophic factor that enhances survival of midbrain dopaminergic neurons was purified and cloned. Glial cell line-derived neurotrophic factor (GDNF) is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e9e99e0859a2d469e259589196f5c1
https://doi.org/10.1126/science.8493557
https://doi.org/10.1126/science.8493557
Publikováno v:
Journal of neurochemistry. 66(1)
The effect of glial cell line-derived neurotrophic factor (GDNF) on the growth of mesencephalic dopaminergic neurons and on their survival following exposure to the neurotoxin 1-methyl-4-phenylpyridinium (MPP + ) was examined in vitro. In cultures de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e15fc794026ef4d307975903784d61c
https://pubmed.ncbi.nlm.nih.gov/8522992
https://pubmed.ncbi.nlm.nih.gov/8522992
Glial cell line-derived neurotrophic factor (GDNF) has been shown to rescue developing motoneurons in vivo and in vitro from both naturally occurring and axotomy-induced cell death. To test whether GDNF has trophic effects on adult motoneurons, we us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a5cd30d16975b1c8f33728025dfa8d
https://europepmc.org/articles/PMC40884/
https://europepmc.org/articles/PMC40884/
Autor:
Ted Ebendal, Barry J. Hoffer, Johan Widenfalk, Tadahiko Kohno, Andreas Tomac, Leu-Fen H. Lin, Lars Olson
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 92(18)
The recently cloned, distant member of the transforming growth factor beta (TGF-beta) family, glial cell line-derived neurotrophic factor (GDNF), has potent trophic actions on fetal mesencephalic dopamine neurons. GDNF also has protective and restora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0985ab79c33d584eb5204e4bfdc373e
https://pubmed.ncbi.nlm.nih.gov/7667281
https://pubmed.ncbi.nlm.nih.gov/7667281
Publikováno v:
Journal of neurochemistry. 63(2)
The rat glial cell line B49 releases into its culture medium a potent neurotrophic factor that exhibits relative specificity for the dopaminergic neurons in dissociated cultures of rat embryonic midbrain. This factor is a heparin-binding, basic prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430117148b2589127050fc3056209025
https://pubmed.ncbi.nlm.nih.gov/8035200
https://pubmed.ncbi.nlm.nih.gov/8035200
Autor:
Leu-Fen H. Lin, Marjorie B. Lees
Publikováno v:
Neurochemical Research. 9:1515-1522
Dicyclohexylcarbodiimide (DCCD), an inhibitor of proton translocation, has been shown to bind preferentially to the myelin proteolipid and to inhibit proton movement in liposomes containing the proteolipid (Lin, L. and Lees, M. 1982. Proc. Natl. Acad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc87454cdaf9338eaad144debd36ca1
https://doi.org/10.1007/bf00964677
https://doi.org/10.1007/bf00964677
Publikováno v:
Archives of Biochemistry and Biophysics. 226:643-656
The sequence of the bovine white matter proteolipid has been studied by a combination of proteolytic digestion and chemical cleavage at tryptophan residues. Alignment of peptides obtained by digestion with trypsin, chymotrypsin, clostripain, and Stap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24aae190b3886d1ad00398bf6c9a0ddc
https://doi.org/10.1016/0003-9861(83)90334-x
https://doi.org/10.1016/0003-9861(83)90334-x
Publikováno v:
Archives of Biochemistry and Biophysics. 160:458-464
The inhibitors of protein synthesis, chloramphenicol and cycloheximide, were added to cultures of yeast undergoing glucose derepression at different times during the growth cycle. Both inhibitors blocked the increase in activity of coenzyme QH 2 -cyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35c84a00caba6d19cc51e2ef724856f0
https://doi.org/10.1016/0003-9861(74)90421-4
https://doi.org/10.1016/0003-9861(74)90421-4