Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Letizia Magnoni"'
Autor:
Giuseppe Pollio, Jeroen J.M. Hoozemans, Claus A. Andersen, Renza Roncarati, Maria Cristina Rosi, Elise S. van Haastert, Tamara Seredenina, Daniela Diamanti, Stefano Gotta, Anna Fiorentini, Letizia Magnoni, Roberto Raggiaschi, Annemieke J.M. Rozemuller, Fiorella Casamenti, Andrea Caricasole, Georg C. Terstappen
Publikováno v:
Neurobiology of Disease, Vol 31, Iss 1, Pp 145-158 (2008)
In a comprehensive proteomics study aiming at the identification of proteins associated with amyloid-beta (Aβ)-mediated toxicity in cultured cortical neurons, we have identified Thimet oligopeptidase (THOP1). Functional modulation of THOP1 levels in
Externí odkaz:
https://doaj.org/article/f395872d345c4193af394d962f5995fb
Autor:
Antonella De Rosa, Serena Pellegatta, Marco Rossi, Patrizia Tunici, Letizia Magnoni, Maria Carmela Speranza, Federico Malusa, Vincenzo Miragliotta, Elisa Mori, Gaetano Finocchiaro, Annette Bakker
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52113 (2012)
Glioblastoma multiforme (GBM) is among the most deadly cancers. A number of studies suggest that a fraction of tumor cells with stem cell features (Glioma Stem-like Cells, GSC) might be responsible for GBM recurrence and aggressiveness. GSC similarly
Externí odkaz:
https://doaj.org/article/0b1fde6b883c4ea0bb4991517c92c127
Autor:
Claudio Cucini, Francesco Nardi, Letizia Magnoni, Lorena Rebecchi, Roberto Guidetti, Peter Convey, Antonio Carapelli
The temperature experienced by micro-invertebrates in extreme environments (such as those of Antarctica) is a pivotal parameter regarding these animals' ecology and physiology. However, at present, detailed knowledge of microhabitat physical conditio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bbb26c65c86fe496d1203ea3e45bb1b
https://hdl.handle.net/11380/1270823
https://hdl.handle.net/11380/1270823
Autor:
Giovanna Tripepi, Ruth Farmer, Salman Haider, Monika Rudzińska, G Westerberg, Sebastian Brzozy, Karin Schiefele, Elisa Mori, Letizia Magnoni, Michael Orth, Sarah J. Tabrizi, Ralph Andre, Marco Di Bacco, Carsten Saft, Danuta Ryglewicz, Giuseppe Pollio, Daniela Diamanti, Chris Frost, Claus A. Andersen, Sigurd D. Süssmuth, Enrica Diodato, Luisa Massai, Jens Dreyhaupt, Claudia Lamanna, Anna Baran, Borje Darpo, David Craufurd, G. Bernhard Landwehrmeyer
Publikováno v:
British Journal of Clinical Pharmacology. 79:465-476
AIMS: Selisistat, a selective SirT1 inhibitor is being developed as a potentially disease-modifying therapeutic for Huntington's disease (HD). This was the first study of selisistat in HD patients and was primarily aimed at development of pharmacodyn
Autor:
Borje Darpo, Meijian Zhou, Daniela Diamanti, Giuseppe Pollio, Letizia Magnoni, Claus A. Andersen, G Westerberg, Joseph A. Chiesa
Publikováno v:
British Journal of Clinical Pharmacology. 79:477-491
Aim Selisistat (SEN0014196), a first-in-class SirT1 inhibitor, is being developed as a disease-modifying therapy for Huntington's disease. This first-in-human study investigated the safety, pharmacokinetics and pharmacogenomics of single and multiple
Autor:
Cesare Federico, Andrea Caricasole, Letizia Magnoni, Wolfgang Fecke, Valentina Porcari, Freddy Heitz, Giulia Lazzeroni, Salvatore La Rosa, Luisa Massai, Tiziana Benicchi, Lara Rossini, Daniela Diamanti
Publikováno v:
SLAS Discovery. 18:984-996
Huntington's Disease is a rare neurodegenerative disease caused by an abnormal expansion of CAG repeats encoding polyglutamine in the first exon of the huntingtin gene. N-terminal fragments containing polyglutamine (polyQ) sequences aggregate and can
Autor:
Giuseppe Pollio, Costanza Fondelli, Alessia Tarditi, Daniela Diamanti, Letizia Magnoni, Andrea Caricasole, Giovanna Tripepi, Elisa Mori, Enrica Diodato, Federico Malusa, Sarah J. Tabrizi, Emilia Morena, Nayana Lahiri
Publikováno v:
Journal of Huntington's Disease. 2:185-200
BACKGROUND: Huntington's disease is a neurodegenerative disorder characterized by transcriptional alterations both in central and peripheral tissues. Therefore, the identification of a transcriptional signature in an accessible tissue can meaningfull
Autor:
Silvia Valensin, Enrica Diodato, Elena Pilli, Carla Scali, Luisa Massai, Roberta Magrini, Riccardo Roggeri, Antonella De Rosa, Fabio A. Recchia, Nicola P. Caradonna, Sara Chellini, Giuseppe Pollio, Patrizia Tunici, Valentina Porcari, Gianluca Sardone, Pasquale Fiengo, Letizia Magnoni, Silvia Coniglio, Vincenzo Lionetti, Daniela Diamanti, Martina Monti, Marco Rossi
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 86
Preclinical imaging modalities represent an essential tool to develop a modern and translational biomedical research. To date, Optical Imaging (OI) and Magnetic Resonance Imaging (MRI) are used principally in separate studies for molecular imaging st
Autor:
Cinzia Giordano, Annette Bakker, Marco Rossi, Rossana Ritelli, Mario D'Andrea, Licia Montagna, Letizia Magnoni, Patrizia Tunici, Silvia Valensin, Margherita Gaviraghi, Aldo Scarpa
Publikováno v:
Bioscience Reports
Pancreatic cancer stem-like cells are described by membrane expression of CD24, CD44 and ESA (epithelial-specific antigen) and their capacity to grow as spheres in a serum-free medium containing well-defined growth factors. The capacity of a panel of
Autor:
Renza Roncarati, Andrea Caricasole, Anna Fiorentini, Stefano Gotta, Roberto Raggiaschi, Georg C. Terstappen, Letizia Magnoni, Jeroen J.M. Hoozemans, Giuseppe Pollio, Tamara Seredenina, Daniela Diamanti, Elise S. van Haastert, Annemieke J.M. Rozemuller, Claus A. Andersen, Maria Cristina Rosi, Fiorella Casamenti
Publikováno v:
Neurobiology of Disease, Vol 31, Iss 1, Pp 145-158 (2008)
Pollio, G, Hoozemans, J J M, Andersen, C A, Roncarati, R, Rosi, M C, van Haastert, E S, Seredenina, T, Diamanti, D, Gotta, S, Fiorentini, A, Magnoni, L, Raggiaschi, R, Rozemuller, A J M, Casamenti, F, Caricasole, A & Terstappen, G C 2008, ' Increased expression of the oligopeptidase THOP1 is a neuroprotective response to A beta toxicity ', Neurobiology of Disease, vol. 31, no. 1, pp. 145-158 . https://doi.org/10.1016/j.nbd.2008.04.004
Neurobiology of Disease, 31(1), 145-158. Academic Press Inc.
Pollio, G, Hoozemans, J J M, Andersen, C A, Roncarati, R, Rosi, M C, van Haastert, E S, Seredenina, T, Diamanti, D, Gotta, S, Fiorentini, A, Magnoni, L, Raggiaschi, R, Rozemuller, A J M, Casamenti, F, Caricasole, A & Terstappen, G C 2008, ' Increased expression of the oligopeptidase THOP1 is a neuroprotective response to A beta toxicity ', Neurobiology of Disease, vol. 31, no. 1, pp. 145-158 . https://doi.org/10.1016/j.nbd.2008.04.004
Neurobiology of Disease, 31(1), 145-158. Academic Press Inc.
In a comprehensive proteomics study aiming at the identification of proteins associated with amyloid-beta (Abeta)-mediated toxicity in cultured cortical neurons, we have identified Thimet oligopeptidase (THOP1). Functional modulation of THOP1 levels