Filamin A Modulates Store-Operated Ca 2+ Entry by Regulating STIM1 (Stromal Interaction Molecule 1)–Orai1 Association in Human Platelets

Autor: Jose Sanchez-Collado, Regis Bobe, Jose J. Lopez, Juan A. Rosado, Isaac Jardín, Letizia Albarran, Tarik Smani, Nuria Bermejo, Pedro C. Redondo

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 38:386-397

Objective— Here, we provide evidence for the role of FLNA (filamin A) in the modulation of store-operated calcium entry (SOCE). Approach and Results— SOCE is a major mechanism for calcium influx controlled by the intracellular Ca 2+ stores. On st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::572ce7884dd7edb0ab5facb355961d84
https://doi.org/10.1161/atvbaha.117.310139

Molecular modulators of store-operated calcium entry

Autor: Ginés M. Salido, Tarik Smani, Luis Gómez, Letizia Albarran, Juan A. Rosado, Jose J. Lopez

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1863:2037-2043

Three decades ago, store-operated Ca 2 + entry (SOCE) was identified as a unique mechanism for Ca 2 + entry through plasma membrane (PM) Ca 2 + -permeable channels modulated by the intracellular Ca 2 + stores, mainly the endoplasmic reticulum (ER). E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f02133fdf5e1ae3ae479a18207c957d
https://doi.org/10.1016/j.bbamcr.2016.04.024

EFHB is a Novel Cytosolic Ca2+ Sensor That Modulates STIM1-SARAF Interaction

Autor: Tarik Smani, Jose J. Lopez, Alejandro Berna-Erro, Ginés M. Salido, Pedro J. Camello, Letizia Albarran, Jose Sanchez-Collado, Isaac Jardin, Juan A. Rosado

Publikováno v: Cellular Physiology and Biochemistry, Vol 51, Iss 3, Pp 1164-1178 (2018)
idUS: Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
idUS. Depósito de Investigación de la Universidad de Sevilla
instname

Background/aims: STIM1 and Orai1 are the key components of store-operated Ca2+ entry (SOCE). Among the proteins involved in the regulation of SOCE, SARAF prevents spontaneous activation of SOCE and modulates STIM1 function. Methods: Cytosolic Ca2+ mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ca1fd26c64b51eb59223b867b691ea

New Insights into Adipokines as Potential Biomarkers for Type-2 Diabetes Mellitus

Autor: Pedro C. Redondo, Carlos Cantonero, Jose Sanchez-Collado, Letizia Albarran, Jose J. Lopez, María P. Granados, Marta Olivera-Santa Catalina

Publikováno v: Current medicinal chemistry. 26(22)

A large number of studies have been focused on investigating serum biomarkers associated with risk or diagnosis of type-2 diabetes mellitus. In the last decade, promising studies have shown that circulating levels of adipokines could be used as a rel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebad89ebab1b21c2b0d05a5f02c697bd
https://pubmed.ncbi.nlm.nih.gov/29210636

Transient receptor potential ankyrin-1 (TRPA1) modulates store-operated Ca2+ entry by regulation of STIM1-Orai1 association

Autor: Ginés M. Salido, Letizia Albarran, Natalia Dionisio, Juan A. Rosado, Tarik Smani, Jose J. Lopez

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1833(12):3025-3034

TRPA1 is a non-selective Ca(2+) permeable channel located in the plasma membrane that functions as a cellular sensor detecting mechanical, chemical and thermal stimuli, being a component of neuronal, epithelial, blood and smooth muscle tissues. TRPA1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1199e0ff3ad947cffb4eec06422da97f