Zobrazeno 1 - 10
of 195
pro vyhledávání: '"Letizia, Mazzini"'
Autor:
Giacomo Tondo, Letizia Mazzini, Silvia Paola Caminiti, Chiara Gallo, Roberta Matheoud, Cristoforo Comi, Gian Mauro Sacchetti, Daniela Perani, Fabiola De Marchi
Publikováno v:
Neurobiology of Disease, Vol 199, Iss , Pp 106579- (2024)
Background: The diagnosis of amyotrophic lateral sclerosis (ALS) is primarily clinical, supported by the electromyographic examination to reveal signs of lower motor neuron damage. Identifying reliable markers of upper motor neuron (UMN) involvement
Externí odkaz:
https://doaj.org/article/f7984282d8ad43be8b94ef9f1ab826b7
Autor:
Maurizio Grassano, Umberto Manera, Fabiola De Marchi, Paolo Cugnasco, Enrico Matteoni, Margherita Daviddi, Luca Solero, Alessandro Bombaci, Francesca Palumbo, Rosario Vasta, Antonio Canosa, Paolina Salamone, Giuseppe Fuda, Federico Casale, Letizia Mazzini, Andrea Calvo, Cristina Moglia, Adriano Chiò
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 9, Pp 1623-1632 (2023)
Abstract Background Systemic inflammation has been proposed as a relevant mechanism in amyotrophic lateral sclerosis (ALS). Still, comprehensive data on ALS patients' innate and adaptive immune responses and their effect on the clinical phenotype are
Externí odkaz:
https://doaj.org/article/25c1bc3aac9943a0a7a952f2d3ffa46b
Autor:
Jessica Mandrioli, Roberto D’Amico, Elisabetta Zucchi, Sara De Biasi, Federico Banchelli, Ilaria Martinelli, Cecilia Simonini, Domenico Lo Tartaro, Roberto Vicini, Nicola Fini, Giulia Gianferrari, Marcello Pinti, Christian Lunetta, Francesca Gerardi, Claudia Tarlarini, Letizia Mazzini, Fabiola De Marchi, Ada Scognamiglio, Gianni Sorarù, Andrea Fortuna, Giuseppe Lauria, Eleonora Dalla Bella, Claudia Caponnetto, Giuseppe Meo, Adriano Chio, Andrea Calvo, Andrea Cossarizza
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract In preclinical studies rapamycin was found to target neuroinflammation, by expanding regulatory T cells, and affecting autophagy, two pillars of amyotrophic lateral sclerosis (ALS) pathogenesis. Herein we report a multicenter, randomized, do
Externí odkaz:
https://doaj.org/article/b047af166d3e4b93aacae7ef3e501443
Autor:
Beatrice Vilardo, Fabiola De Marchi, Davide Raineri, Marcello Manfredi, Veronica De Giorgis, Alen Bebeti, Lorenza Scotti, Natasa Kustrimovic, Giuseppe Cappellano, Letizia Mazzini, Annalisa Chiocchetti
Publikováno v:
Biomolecules, Vol 14, Iss 6, p 727 (2024)
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder lacking reliable biomarkers for early diagnosis and disease progression monitoring. This study aimed to identify the novel biomarkers in plasmatic extracellular vesicles
Externí odkaz:
https://doaj.org/article/18d7f2ad22874069969188f454264c6c
Autor:
Giacomo Tondo, Fabiola De Marchi, Francesca Bonardi, Federico Menegon, Gaia Verrini, Davide Aprile, Matteo Anselmi, Letizia Mazzini, Cristoforo Comi
Publikováno v:
Journal of Clinical Medicine, Vol 13, Iss 11, p 3098 (2024)
Alzheimer’s disease (AD) causes a significant challenge to global healthcare systems, with limited effective treatments available. This review examines the landscape of novel therapeutic strategies for AD, focusing on the shortcomings of traditiona
Externí odkaz:
https://doaj.org/article/af07a56a950b42b88a38ec7f61615e3a
Autor:
Michele Lombardi, Lucia Corrado, Beatrice Piola, Cristoforo Comi, Roberto Cantello, Sandra D’Alfonso, Letizia Mazzini, Fabiola De Marchi
Publikováno v:
Genes, Vol 14, Iss 11, p 2039 (2023)
Mutations in the 43 kDa transactive-response (TAR)-DNA-binding protein (TARDBP) are associated with 2–5% of familial Amyotrophic Lateral Sclerosis (ALS) cases. TAR DNA-Binding Protein 43 (TDP-43) is an RNA/DNA-binding protein involved in several ce
Externí odkaz:
https://doaj.org/article/12afbf522e204977ac61d5aaea0fe197
Autor:
Elena Grossini, Fabiola De Marchi, Sakthipriyan Venkatesan, Angelica Mele, Daniela Ferrante, Letizia Mazzini
Publikováno v:
Antioxidants, Vol 12, Iss 10, p 1887 (2023)
Oxidative stress, the alteration of mitochondrial function, and the neurovascular unit (NVU), play a role in Amyotrophic Lateral Sclerosis (ALS) pathogenesis. We aimed to demonstrate the changes in the plasma redox system and nitric oxide (NO) in 32
Externí odkaz:
https://doaj.org/article/8f9254f8c87b4fdda3d21cefb7b08677
Autor:
Fabiola De Marchi, Ivana Munitic, Lea Vidatic, Eliša Papić, Valentino Rački, Jerneja Nimac, Igor Jurak, Gabriela Novotni, Boris Rogelj, Vladimira Vuletic, Rajka M. Liscic, Jason R. Cannon, Emanuele Buratti, Letizia Mazzini, Silva Hecimovic
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2793 (2023)
Many potential immune therapeutic targets are similarly affected in adult-onset neurodegenerative diseases, such as Alzheimer’s (AD) disease, Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD), as wel
Externí odkaz:
https://doaj.org/article/473fce8945424961988b168cd6f23534
Autor:
Chiara Gallo, Letizia Mazzini, Claudia Varrasi, Domizia Vecchio, Eleonora Virgilio, Roberto Cantello
Publikováno v:
NeuroSci, Vol 3, Iss 2, Pp 321-331 (2022)
Unilateral facial nerve palsy (FNP) is one of the most common cranial mononeuropathies. Among rare etiologies, neurosarcoidosis (NS) can cause bilateral involvement (both recurring and simultaneous) only in 15% to 25% of cases. The rarity of this sys
Externí odkaz:
https://doaj.org/article/f17e9ca4043649a7ac4bf00d013c4811
Autor:
Fabiola De Marchi, Giacomo Tondo, Lucia Corrado, Federico Menegon, Davide Aprile, Matteo Anselmi, Sandra D’Alfonso, Cristoforo Comi, Letizia Mazzini
Publikováno v:
Genes, Vol 14, Iss 8, p 1658 (2023)
Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal dementia (FDT) are progressive neurodegenerative disorders that, in several cases, overlap in clinical presentation, and genetic and pathological disease mechanisms. About 10–15% of ALS cases a
Externí odkaz:
https://doaj.org/article/0c9971afbdcb4084baabc750fd2fa1b4