Zobrazeno 1 - 10
of 418
pro vyhledávání: '"Letizia, Mazzini"'
Autor:
Giacomo Tondo, Letizia Mazzini, Silvia Paola Caminiti, Chiara Gallo, Roberta Matheoud, Cristoforo Comi, Gian Mauro Sacchetti, Daniela Perani, Fabiola De Marchi
Publikováno v:
Neurobiology of Disease, Vol 199, Iss , Pp 106579- (2024)
Background: The diagnosis of amyotrophic lateral sclerosis (ALS) is primarily clinical, supported by the electromyographic examination to reveal signs of lower motor neuron damage. Identifying reliable markers of upper motor neuron (UMN) involvement
Externí odkaz:
https://doaj.org/article/f7984282d8ad43be8b94ef9f1ab826b7
Autor:
Maurizio Grassano, Umberto Manera, Fabiola De Marchi, Paolo Cugnasco, Enrico Matteoni, Margherita Daviddi, Luca Solero, Alessandro Bombaci, Francesca Palumbo, Rosario Vasta, Antonio Canosa, Paolina Salamone, Giuseppe Fuda, Federico Casale, Letizia Mazzini, Andrea Calvo, Cristina Moglia, Adriano Chiò
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 9, Pp 1623-1632 (2023)
Abstract Background Systemic inflammation has been proposed as a relevant mechanism in amyotrophic lateral sclerosis (ALS). Still, comprehensive data on ALS patients' innate and adaptive immune responses and their effect on the clinical phenotype are
Externí odkaz:
https://doaj.org/article/25c1bc3aac9943a0a7a952f2d3ffa46b
Autor:
Beatrice Vilardo, Fabiola De Marchi, Davide Raineri, Marcello Manfredi, Veronica De Giorgis, Alen Bebeti, Lorenza Scotti, Natasa Kustrimovic, Giuseppe Cappellano, Letizia Mazzini, Annalisa Chiocchetti
Publikováno v:
Biomolecules, Vol 14, Iss 6, p 727 (2024)
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder lacking reliable biomarkers for early diagnosis and disease progression monitoring. This study aimed to identify the novel biomarkers in plasmatic extracellular vesicles
Externí odkaz:
https://doaj.org/article/18d7f2ad22874069969188f454264c6c
Autor:
Jessica Mandrioli, Roberto D’Amico, Elisabetta Zucchi, Sara De Biasi, Federico Banchelli, Ilaria Martinelli, Cecilia Simonini, Domenico Lo Tartaro, Roberto Vicini, Nicola Fini, Giulia Gianferrari, Marcello Pinti, Christian Lunetta, Francesca Gerardi, Claudia Tarlarini, Letizia Mazzini, Fabiola De Marchi, Ada Scognamiglio, Gianni Sorarù, Andrea Fortuna, Giuseppe Lauria, Eleonora Dalla Bella, Claudia Caponnetto, Giuseppe Meo, Adriano Chio, Andrea Calvo, Andrea Cossarizza
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract In preclinical studies rapamycin was found to target neuroinflammation, by expanding regulatory T cells, and affecting autophagy, two pillars of amyotrophic lateral sclerosis (ALS) pathogenesis. Herein we report a multicenter, randomized, do
Externí odkaz:
https://doaj.org/article/b047af166d3e4b93aacae7ef3e501443
Autor:
Chiara Gallo, Letizia Mazzini, Claudia Varrasi, Domizia Vecchio, Eleonora Virgilio, Roberto Cantello
Publikováno v:
NeuroSci, Vol 3, Iss 2, Pp 321-331 (2022)
Unilateral facial nerve palsy (FNP) is one of the most common cranial mononeuropathies. Among rare etiologies, neurosarcoidosis (NS) can cause bilateral involvement (both recurring and simultaneous) only in 15% to 25% of cases. The rarity of this sys
Externí odkaz:
https://doaj.org/article/f17e9ca4043649a7ac4bf00d013c4811
Autor:
Elena Grossini, Fabiola De Marchi, Sakthipriyan Venkatesan, Angelica Mele, Daniela Ferrante, Letizia Mazzini
Publikováno v:
Antioxidants, Vol 12, Iss 10, p 1887 (2023)
Oxidative stress, the alteration of mitochondrial function, and the neurovascular unit (NVU), play a role in Amyotrophic Lateral Sclerosis (ALS) pathogenesis. We aimed to demonstrate the changes in the plasma redox system and nitric oxide (NO) in 32
Externí odkaz:
https://doaj.org/article/8f9254f8c87b4fdda3d21cefb7b08677
Autor:
Fabiola De Marchi, Ivana Munitic, Lea Vidatic, Eliša Papić, Valentino Rački, Jerneja Nimac, Igor Jurak, Gabriela Novotni, Boris Rogelj, Vladimira Vuletic, Rajka M. Liscic, Jason R. Cannon, Emanuele Buratti, Letizia Mazzini, Silva Hecimovic
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2793 (2023)
Many potential immune therapeutic targets are similarly affected in adult-onset neurodegenerative diseases, such as Alzheimer’s (AD) disease, Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD), as wel
Externí odkaz:
https://doaj.org/article/473fce8945424961988b168cd6f23534
Autor:
Cynthia Morata-Tarifa, Garikoitz Azkona, Jonathan Glass, Letizia Mazzini, Rosario Sanchez-Pernaute
Publikováno v:
npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-10 (2021)
Abstract Transplantation of several types of stem cells (SC) for the treatment of amyotrophic lateral sclerosis (ALS) has been evaluated in numerous Phase I/II clinical trials with inconclusive results. Here, we conducted a meta-analysis to systemati
Externí odkaz:
https://doaj.org/article/2fbb57f2b2d8490a838bf471fd9df03c
Autor:
Fabiola De Marchi, Toni Franjkic, Paride Schito, Tommaso Russo, Jerneja Nimac, Anna A. Chami, Angelica Mele, Lea Vidatic, Jasna Kriz, Jean-Pierre Julien, Gordana Apic, Robert B. Russell, Boris Rogelj, Jason R. Cannon, Marco Baralle, Federica Agosta, Silva Hecimovic, Letizia Mazzini, Emanuele Buratti, Ivana Munitic
Publikováno v:
Biomedicines, Vol 11, Iss 6, p 1599 (2023)
Proteinopathy and neuroinflammation are two main hallmarks of neurodegenerative diseases. They also represent rare common events in an exceptionally broad landscape of genetic, environmental, neuropathologic, and clinical heterogeneity present in pat
Externí odkaz:
https://doaj.org/article/1d4499cfcc20462c9f6f60178f9f2d72
Autor:
Diana Di Gioia, Nicole Bozzi Cionci, Loredana Baffoni, Angela Amoruso, Marco Pane, Luca Mogna, Francesca Gaggìa, Maria Ausiliatrice Lucenti, Enrica Bersano, Roberto Cantello, Fabiola De Marchi, Letizia Mazzini
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-19 (2020)
Abstract Background A connection between amyotrophic lateral sclerosis (ALS) and altered gut microbiota composition has previously been reported in animal models. This work is the first prospective longitudinal study addressing the microbiota composi
Externí odkaz:
https://doaj.org/article/15d36d648fc645b38d7a291dc306a1d9