Výsledky vyhledávání - "Letitia Sarah"

First-in-Class Allosteric Inhibitors of DNMT3A Disrupt Protein–Protein Interactions and Induce Acute Myeloid Leukemia Cell Differentiation

Autor: Jonathan E. Sandoval, Raghav Ramabadran, Nathaniel Stillson, Letitia Sarah, Danica Galonić Fujimori, Margaret A. Goodell, Norbert Reich

Publikováno v: Journal of Medicinal Chemistry. 65:10554-10566

We previously identified two structurally related pyrazolone (compound 1) and pyridazine (compound 2) allosteric inhibitors of DNMT3A through screening of a small chemical library. Here, we show that these compounds bind and disrupt protein-protein i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4687bef218fc881adcbf7a0f0a9f0196
https://doi.org/10.1021/acs.jmedchem.2c00725

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Functional multi-omics reveals genetic and pharmacologic regulation of surface CD38 in multiple myeloma

Autor: Byron Hann, Olivia Gugliemini, Letitia Sarah, Poornima Ramkumar, Martin Kampmann, Yu-Hsiu T. Lin, Veronica Steri, Donghui Wang, Arun P. Wiita, Priya Choudhry, Huimin Geng, Vishesh Sarin, Paul Phojanakong, Neha Paranjape, Makeba Marcoulis

Background: CD38 is a surface ectoenzyme expressed at high levels on myeloma plasma cells and is the target for the monoclonal antibodies (mAbs) daratumumab and isatuximab. These antibodies have multiple mechanisms of action, primarily involving recr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a6d97ac42c082f13ff8c100f02a76a
https://doi.org/10.1101/2021.08.04.455165

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