Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Leticia Toledo"'
Publikováno v:
Novedades en Población, Vol XI, Iss 22, Pp 20-28 (2015)
Resumen Villa Clara es la provincia más envejecida del país y la atención a este proceso demográfico se declara como urgente para este territorio. El artículo que se presenta constituye un resultado parcial del estudio que viene realizando,
Externí odkaz:
https://doaj.org/article/e9c043b3581c48e2b5fccfb442354f70
Autor:
Cristina Cariulo, Paola Martufi, Margherita Verani, Leticia Toledo-Sherman, Ramee Lee, Celia Dominguez, Lara Petricca, Andrea Caricasole
N-terminal phosphorylation at residues T3 and S13 is believed to have important beneficial implications for the biological and pathological properties of mutant huntingtin, where IKBKB was identified as a candidate regulator of huntingtin N-terminal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d13f72186139ace7ba098b3f77b0935
https://doi.org/10.1101/2022.12.05.519070
https://doi.org/10.1101/2022.12.05.519070
Autor:
Georg Kempf, Ignacio Munoz-Sanjuan, Alexandros Patsilinakos, Matteo Andreini, Stefania Colarusso, Vincenzo Summa, Jesus Maria Ontoria Ontoria, Federica Ferrigno, Paola Fezzardi, Steven J. Harper, Leticia Toledo Sherman, Stefan Steinbacher, Ilaria Biancofiore, Esther Torrente, Martin Augustin, Elisabetta Bianchi, Larry Park, Alberto Bresciani, Robert Pacifici, Celia Dominguez
Publikováno v:
ACS Med Chem Lett
[Image: see text] The NRF2-ARE pathway is an intrinsic mechanism of defense against oxidative stress. Inhibition of the interaction between NRF2 and its main negative regulator KEAP1 is an attractive strategy toward neuroprotective agents. We report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697530dc3724a96d48064e27557ca038
https://doi.org/10.1021/acsmedchemlett.9b00594
https://doi.org/10.1021/acsmedchemlett.9b00594
Autor:
Margherita Verani, Paola Martufi, Celia Dominguez, Ramee Lee, Lara Petricca, Raffaele Ingenito, Cristina Cariulo, Daniel J. Lavery, Marco Finotto, Leticia Toledo-Sherman, Sean M. DeGuire, Andrea Caricasole, Thomas F. Vogt, Elizabeth M. Doherty, Hilal A. Lashuel
Publikováno v:
Biochemical and Biophysical Research Communications. 521:549-554
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expansion of a CAG triplet repeat (encoding for a polyglutamine tract) within the first exon of the huntingtin gene. Expression of the mutant huntingtin (mHTT) protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708a06a05dc236486abebc8e82acb464
https://doi.org/10.1016/j.bbrc.2019.09.097
https://doi.org/10.1016/j.bbrc.2019.09.097
Autor:
Sarah L. Martin, Dawn Yates, Grant Wishart, Ignacio Munoz-Sanjuan, Wesley Blackaby, Ovadia Lazari, Roger Cachope, Amanda Van de Poël, Leticia Toledo-Sherman, Esmieu William R K, Ivan Angulo-Herrera, Celia Dominguez, Rebecca E. Jarvis, Helen C. Cox, Amy Barnard, Graham Jones, Marcus Peacock, Sung-Wook Jang, Perla Breccia, Jennifer R. Bate, Cole Clissold, Philip Leonard, Maria Eznarriaga, Marieke Lamers, Mark Rose, George McAllister, Kim L. Matthews, Huw D. Vater
Publikováno v:
Journal of medicinal chemistry. 64(8)
Our group has recently shown that brain-penetrant ataxia telangiectasia-mutated (ATM) kinase inhibitors may have potential as novel therapeutics for the treatment of Huntington's disease (HD). However, the previously described pyranone-thioxanthenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f36cf11e03a84484aef8a9c43f147a9d
https://pubmed.ncbi.nlm.nih.gov/33783225
https://pubmed.ncbi.nlm.nih.gov/33783225
Autor:
Paola Fezzardi, Steven J. Harper, Alberto Bresciani, Licia Tomei, Leticia-Toledo Sherman, Ignacio Munoz-Sajuan, Larry Park, Antonino Missineo, Mauro Cerretani, Robert Pacifici, Celia Dominquez, Daniele Moretti, Sara Tambone
Publikováno v:
Free radical biologymedicine. 162
Oxidative stress has been associated with pathogenesis in several diseases including Huntington's disease (HD), a neurodegenerative disorder caused by a mutation in the huntingtin gene. Oxidative stress induced reactive oxygen species (ROS) are norma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c125dfcb529779046473cfcc08c87c5
https://pubmed.ncbi.nlm.nih.gov/33096251
https://pubmed.ncbi.nlm.nih.gov/33096251
Publikováno v:
Revista dos Mestrados Profissionais. 6
U ma das principais causas de perda de receita e a fraude. E com o crescente volume e armazenamento de dados varias empresas torna-se inviavel a analise manual de todos os dados. O uso do KDD e ( Knowledge Discovery in Database - Descoberta de conhec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c977bf2f3d5ea8c742f84f5db1b9b56c
https://doi.org/10.52614/2317-0115.2017.245170
https://doi.org/10.52614/2317-0115.2017.245170
Akademický článek
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Akademický článek
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Autor:
Daniel O. Cicero, Elisabetta Bianchi, Leticia Toledo-Sherman, Ignacio Munoz-Sanjuan, Paola Fezzardi, Licia Tomei, Robert Pacifici, Alessia Santoprete, Alberto Bresciani, Celia Dominguez, Antonino Missineo, Larry Park, Raffaele Ingenito, Mauro Cerretani, Sergio Altamura, Steven J. Harper, Mariana Gallo
Publikováno v:
Archives of Biochemistry and Biophysics. 631:31-41
Mechanisms that activate innate antioxidant responses, as a way to mitigate oxidative stress at the site of action, hold much therapeutic potential in diseases, such as Parkinson's disease, Alzheimer's disease and Huntington's disease, where the use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23111e296eb4dd845228e78fe4f9832e
https://doi.org/10.1016/j.abb.2017.08.003
https://doi.org/10.1016/j.abb.2017.08.003