Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Leticia Stock"'
Autor:
Leticia Stock, Lydia Robinson-Mailman, Long C. Nguyen, Shao-Nong Chen, Guido F. Pauli, Marsha R. Rosner
Publikováno v:
Cancer Research. 83:793-793
CBD, an FDA approved drug for epilepsy, may have therapeutic potential for other diseases and is currently being tested for efficacy in cancer-related clinical trials. As the literature about CBD, especially in vitro reports, is often contradictory,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff749974677e20c46c3f2ccffcd32d4a
https://doi.org/10.1158/1538-7445.am2023-793
https://doi.org/10.1158/1538-7445.am2023-793
Publikováno v:
Biophysical Journal. 118:141a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8414d50ae3aceebc45a53b9c26b1452
https://doi.org/10.1016/j.bpj.2019.11.896
https://doi.org/10.1016/j.bpj.2019.11.896
Publikováno v:
Biophysical Journal. 118:420a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98e019a421ded311457aa13eda45d9f1
https://doi.org/10.1016/j.bpj.2019.11.2370
https://doi.org/10.1016/j.bpj.2019.11.2370
Publikováno v:
Biophysical Journal. 118:48a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3747106464238625d7277db5ba846872
https://doi.org/10.1016/j.bpj.2019.11.441
https://doi.org/10.1016/j.bpj.2019.11.441
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 11, p e1006605 (2018)
PLoS Computational Biology
PLoS Computational Biology
The direct-site hypothesis assumes general anesthetics bind ion channels to impact protein equilibrium and function, inducing anesthesia. Despite advancements in the field, a first principle all-atom demonstration of this structure-function premise i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f337ca07cb645b2f4c7c06d05b8115e
https://doaj.org/article/4378ad12f3e44171934baa72e18383f7
https://doaj.org/article/4378ad12f3e44171934baa72e18383f7
Publikováno v:
ACS Omega
ACS Omega, Vol 3, Iss 11, Pp 15916-15923 (2018)
ACS Omega, Vol 3, Iss 11, Pp 15916-15923 (2018)
2,2,2-Trichloroethanol (TCE) is the active form of the sedative hypnotic drug chloral hydrate, one of the oldest sleep medications in the market. Understanding of TCE's action mechanisms to its many targets, particularly within the ion channel family
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b57f8e8d076df9d8190126cb7e813b5
https://pubmed.ncbi.nlm.nih.gov/30556017
https://pubmed.ncbi.nlm.nih.gov/30556017
The direct-site hypothesis assumes general anesthetics bind ion channels to impact protein equilibrium and function, inducing anesthesia. Despite advancements in the field, a first-principle all-atom demonstration of this structure-function premise m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b781e2b2a2f7d131ead39cf485079765
https://doi.org/10.1101/266809
https://doi.org/10.1101/266809
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Membrane proteins are primary targets for most therapeutic indications in cancer and neurological diseases, binding over 50% of all known small molecule drugs. Understanding how such ligands impact membrane proteins requires knowledge on the molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674ef2e53a07df839c795b74b68ee58a
http://europepmc.org/articles/PMC5516019
http://europepmc.org/articles/PMC5516019
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 4885-4891 (2022)
In the category of functional low-affinity interactions, small ligands may interact with multiple protein sites in a highly degenerate manner. Better conceived as a partition phenomenon at the molecular interface of proteins, such low-affinity intera
Externí odkaz:
https://doaj.org/article/296617b07d8242da8ef69fa1e7e5de7d
Autor:
Long C. Nguyen, David M. Renner, Diane Silva, Dongbo Yang, Nicholas A. Parenti, Kaeri M. Medina, Vlad Nicolaescu, Haley Gula, Nir Drayman, Andrea Valdespino, Adil Mohamed, Christopher Dann, Kristin Wannemo, Lydia Robinson-Mailman, Alan Gonzalez, Letícia Stock, Mengrui Cao, Zeyu Qiao, Raymond E. Moellering, Savas Tay, Glenn Randall, Michael F. Beers, Marsha Rich Rosner, Scott A. Oakes, Susan R. Weiss
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed over 6 million individuals worldwide and continues to spread in countries where vaccines are not yet widely available or its citizens are hesitant to become vaccinated.
Externí odkaz:
https://doaj.org/article/5cf75b97da964ea0a46a9ad54694937e