Gut microbiota produces biofilm-associated amyloids with potential for neurodegeneration

Autor: Ariadna Fernández-Calvet, Leticia Matilla-Cuenca, María Izco, Susanna Navarro, Miriam Serrano, Salvador Ventura, Javier Blesa, Maite Herráiz, Gorka Alkorta-Aranburu, Sergio Galera, Igor Ruiz de los Mozos, María Luisa Mansego, Alejandro Toledo-Arana, Lydia Alvarez-Erviti, Jaione Valle

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Abstract Age-related neurodegenerative diseases involving amyloid aggregation remain one of the biggest challenges of modern medicine. Alterations in the gastrointestinal microbiome play an active role in the aetiology of neurological disorders. Here

Externí odkaz: https://doaj.org/article/40b541987ebf412386b91ac11bd1521e

Regulation of Heterogenous LexA Expression in Staphylococcus aureus by an Antisense RNA Originating from Transcriptional Read-Through upon Natural Mispairings in the sbrB Intrinsic Terminator

Autor: Laurène Bastet, Pilar Bustos-Sanmamed, Arancha Catalan-Moreno, Carlos J. Caballero, Sergio Cuesta, Leticia Matilla-Cuenca, Maite Villanueva, Jaione Valle, Iñigo Lasa, Alejandro Toledo-Arana

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 1, p 576 (2022)

Bacterial genomes are pervasively transcribed, generating a wide variety of antisense RNAs (asRNAs). Many of them originate from transcriptional read-through events (TREs) during the transcription termination process. Previous transcriptome analyses

Externí odkaz: https://doaj.org/article/9b19506c416a4769bcc2861cedba1ee2

The biofilm-associated surface protein Esp of Enterococcus faecalis forms amyloid-like fibers

Autor: Salvador Ventura, James A. Garnett, Leticia Matilla-Cuenca, Agustina Taglialegna, Jaione Valle, Susanna Navarro, Iñigo Lasa, Pedro Dorado-Morales

Publikováno v: npj Biofilms and Microbiomes, Vol 6, Iss 1, Pp 1-12 (2020)
Academica-e: Repositorio Institucional de la Universidad Pública de Navarra
Universidad Pública de Navarra
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
NPJ Biofilms and Microbiomes
Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname
Digital.CSIC. Repositorio Institucional del CSIC

Functional amyloids are considered as common building block structures of the biofilm matrix in different bacteria. In previous work, we have shown that the staphylococcal surface protein Bap, a member of the Biofilm-Associated Proteins (BAP) family,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7d20450669fcfe12e047455232f5e5
http://link.springer.com/article/10.1038/s41522-020-0125-2

Anti-Biofilm Molecules Targeting Functional Amyloids

Autor: Jaione Valle, Alejandro Toledo-Arana, Leticia Matilla-Cuenca

Publikováno v: Antibiotics
Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname
Antibiotics, Vol 10, Iss 795, p 795 (2021)

The choice of an effective therapeutic strategy in the treatment of biofilm-related infections is a significant issue. Amyloids, which have been historically related to human diseases, are now considered to be prevailing structural components of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a0e925567abb054a761d3f9ea71ac6c
http://europepmc.org/articles/PMC8300730