Recombinant antibody against Trypanosoma cruzi from patients with chronic Chagas heart disease recognizes mammalian nervous system.

Autor: Leticia L. Niborski, Mariana Potenza, Renato G.S. Chirivi, Leandro Simonetti, Micaela S. Ossowski, Vanina Grippo, Maria May, Daniela I. Staquicini, Adriana Parodi-Talice, Carlos Robello, Marcelo A. Comini, Guillermo D. Alonso, Jos M.H. Raats, Karina A. Gómez

Publikováno v: EBioMedicine, Vol 63, Iss , Pp 103206- (2021)

Background: To deeply understand the role of antibodies in the context of Trypanosoma cruzi infection, we decided to characterize A2R1, a parasite antibody selected from single-chain variable fragment (scFv) phage display libraries constructed from B

Externí odkaz: https://doaj.org/article/a853729103f84abd87ebff633142d355

Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model

Autor: Alain Doucet, Adeline Bourgeois, Celine Lesaulnier, Edwige Declercq, Martin Reczko, Silvia Cereghini, Petra Zürbig, Maria Kuzma-Kuzniarska, Muriel Umbhauer, Leticia L. Niborski, Mélanie Paces-Fessy, Pierbruno Ricci, Pedro Magalhães

Publikováno v: Disease Models & Mechanisms
article-version (VoR) Version of Record
Disease Models & Mechanisms, Vol 14, Iss 5 (2021)
Disease Models & Mechanisms, Cambridge Company of Biologists, 2021, pp.dmm.047498. ⟨10.1242/dmm.047498⟩
Disease Models & Mechanisms, 2021, pp.dmm.047498. ⟨10.1242/dmm.047498⟩

Heterozygous mutations in HNF1B cause the complex syndrome renal cysts and diabetes (RCAD), characterized by developmental abnormalities of the kidneys, genital tracts and pancreas, and a variety of renal, pancreas and liver dysfunctions. The pathoge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cce66a9e4d43e609ac3b8038cfeb141
http://europepmc.org/articles/PMC8126479

Tissue-resident FOLR2

Autor: Rodrigo, Nalio Ramos, Yoann, Missolo-Koussou, Yohan, Gerber-Ferder, Christian P, Bromley, Mattia, Bugatti, Nicolas Gonzalo, Núñez, Jimena, Tosello Boari, Wilfrid, Richer, Laurie, Menger, Jordan, Denizeau, Christine, Sedlik, Pamela, Caudana, Fiorella, Kotsias, Leticia L, Niborski, Sophie, Viel, Mylène, Bohec, Sonia, Lameiras, Sylvain, Baulande, Laëtitia, Lesage, André, Nicolas, Didier, Meseure, Anne, Vincent-Salomon, Fabien, Reyal, Charles-Antoine, Dutertre, Florent, Ginhoux, Lene, Vimeux, Emmanuel, Donnadieu, Bénédicte, Buttard, Jérôme, Galon, Santiago, Zelenay, William, Vermi, Pierre, Guermonprez, Eliane, Piaggio, Julie, Helft

Publikováno v: Cell. 185(7)

Macrophage infiltration is a hallmark of solid cancers, and overall macrophage infiltration correlates with lower patient survival and resistance to therapy. Tumor-associated macrophages, however, are phenotypically and functionally heterogeneous. Sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::101f9a4f41a01b572a6d7446532beefe
https://pubmed.ncbi.nlm.nih.gov/35325594

Serological based monitoring of a cohort of patients with chronic Chagas disease treated with benznidazole in a highly endemic area of northern Argentina

Autor: Juan M. Burgos, Vilma Ayala, María Coppede, Natalia Anahí Juiz, Crescencia López, Alejandro G. Schijman, Mariano J. Levin, Margarita Bisio, Vanina Grippo, Hugo D Mujica, Leticia L. Niborski, Silvia Andrea Longhi, Facundo Garcia-Bournissen, Karina A. Gómez, Juan Carlos Ramirez, G Levitus, Juan C Elean, Sonia Lafon, Ana Contreras, Verónica Herrera

Publikováno v: Memórias do Instituto Oswaldo Cruz., Vol 111, Iss 6, Pp 365-371 (2016)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Paediatrics Publications
Memórias do Instituto Oswaldo Cruz
Memórias do Instituto Oswaldo Cruz, Volume: 111, Issue: 6, Pages: 365-371, Published: 24 MAY 2016

This study aimed to evaluate well-documented diagnostic antigens, named B13, 1F8 and JL7 recombinant proteins, as potential markers of seroconversion in treated chagasic patients. Prospective study, involving 203 patients treated with benznidazole, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6655021ff5fbd8b70a389b7f9d62b1d
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762016000600365&lng=en&tlng=en

Human recombinant antibodies against Trypanosoma cruzi ribosomal P2β protein

Autor: Leticia L. Niborski, Karina A. Gómez, Vanina Grippo, Mariano J. Levin

Publikováno v: Parasitology. 138(6)

SUMMARYPatients with chronic Chagas' Heart Disease (cChHD) develop an antibody response that is suspected to be involved in the cardiac pathogenesis. The response againstTrypanosoma cruziribosomal P proteins is of particular interest, as these antibo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272b192f391acb751226282500f14001
https://pubmed.ncbi.nlm.nih.gov/21414241