Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Leticia G. Leon"'
Autor:
Stefan J. Erkeland, Christiaan J. Stavast, Joyce Schilperoord-Vermeulen, Giada Dal Collo, Harmen J.G. van de Werken, Leticia G. Leon, Antoinette van Hoven-Beijen, Iris van Zuijen, Yvonne M. Mueller, Eric M. Bindels, Dick de Ridder, Mies C. Kappers-Klunne, Kirsten van Lom, Vincent H.J. van der Velden, Anton W. Langerak
Publikováno v:
Haematologica, Vol 107, Iss 1 (2021)
T-cell prolymphocytic leukemia (T-PLL) is mostly characterized by aberrant expansion of small- to medium-sized prolymphocytes with a mature post-thymic phenotype, high aggressiveness of the disease and poor prognosis. However, T-PLL is more heterogen
Externí odkaz:
https://doaj.org/article/c51dcad216b44704bc99e3de44c2cf7a
Autor:
Ruud W.J. Meijers, Alice F. Muggen, Leticia G. Leon, Maaike de Bie, Jacques J.M. van Dongen, Rudi W. Hendriks, Anton W. Langerak
Publikováno v:
Haematologica, Vol 105, Iss 1 (2020)
Chronic lymphocytic leukemia (CLL) is a disease with heterogeneous clinical and biological characteristics. Differences in Ca2+ levels among cases, both basal and upon B-cell receptor (BCR) stimulation, may reflect heterogeneity in the pathogenesis d
Externí odkaz:
https://doaj.org/article/c0957c08f15f48cc916d717b2d1088c7
Autor:
Lodewijk J. A. Toonen, Maurice Overzier, Melvin M. Evers, Leticia G. Leon, Sander A. J. van der Zeeuw, Hailiang Mei, Szymon M. Kielbasa, Jelle J. Goeman, Kristina M. Hettne, Olafur Th. Magnusson, Marion Poirel, Alexandre Seyer, Peter A. C. ‘t Hoen, Willeke M. C. van Roon-Mom
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-18 (2018)
Abstract Background Spinocerebellar ataxia type 3 (SCA3) is a progressive neurodegenerative disorder caused by expansion of the polyglutamine repeat in the ataxin-3 protein. Expression of mutant ataxin-3 is known to result in transcriptional dysregul
Externí odkaz:
https://doaj.org/article/cf4ff2d151824bce86e17f157244572b
Autor:
Daniela Massihnia, Amir Avan, Niccola Funel, Mina Maftouh, Anne van Krieken, Carlotta Granchi, Rajiv Raktoe, Ugo Boggi, Babette Aicher, Filippo Minutolo, Antonio Russo, Leticia G. Leon, Godefridus J. Peters, Elisa Giovannetti
Publikováno v:
Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-17 (2017)
Abstract Background There is increasing evidence of a constitutive activation of Akt in pancreatic ductal adenocarcinoma (PDAC), associated with poor prognosis and chemoresistance. Therefore, we evaluated the expression of phospho-Akt in PDAC tissues
Externí odkaz:
https://doaj.org/article/2d4ba8f27dcf4bd8ba06725e5e44ca29
Autor:
Iris L. A. Bodewes, Peter J. van der Spek, Leticia G. Leon, Annemarie J. M. Wijkhuijs, Cornelia G. van Helden-Meeuwsen, Liselotte Tas, Marco W. J. Schreurs, Paul L. A. van Daele, Peter D. Katsikis, Marjan A. Versnel
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Background: Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease, where patients often suffer from fatigue. Biological pathways underlying fatigue are unknown. In this study aptamer-based SOMAscan technology is used to identify potentia
Externí odkaz:
https://doaj.org/article/46734dad477b4401b0089d6c67ed3791
Autor:
Elena Galvani, Elisa Giovannetti, Francesca Saccani, Andrea Cavazzoni, Leticia G. Leon, Henk Dekker, Roberta Alfieri, Caterina Carmi, Marco Mor, Andrea Ardizzoni, Pier Giorgio Petronini, Godefridus J. Peters
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 1, Pp 61-72 (2013)
Overcoming the emergence of acquired resistance to clinically approved epidermal growth factor receptor (EGFR) inhibitors is a major challenge in the treatment of advanced non–small cell lung cancer (NSCLC). The aim of this study was to investigate
Externí odkaz:
https://doaj.org/article/367d37976e004f8fb81e5fe6353c68fd
Autor:
Ugo Boggi, Henk M. Verheul, Daniela Campani, Romano Danesi, Alfredo Falcone, Annemieke Groen, Luca E. Pollina, Leticia G. Leon, Enrico Vasile, Leyla A. Erozenci, Marco Del Chiaro, Godefridus J. Peters, Niccola Funel, Elisa Giovannetti
Supplementary Methods from MicroRNA-21 in Pancreatic Cancer: Correlation with Clinical Outcome and Pharmacologic Aspects Underlying Its Role in the Modulation of Gemcitabine Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eb3410ac8abe5aa75f4a87803809e30
https://doi.org/10.1158/0008-5472.22382375.v1
https://doi.org/10.1158/0008-5472.22382375.v1
Autor:
Ugo Boggi, Henk M. Verheul, Daniela Campani, Romano Danesi, Alfredo Falcone, Annemieke Groen, Luca E. Pollina, Leticia G. Leon, Enrico Vasile, Leyla A. Erozenci, Marco Del Chiaro, Godefridus J. Peters, Niccola Funel, Elisa Giovannetti
33,000+KB. May take a few minutes to open
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff0b1a10a44e00fde73988f00c0c567
https://doi.org/10.1158/0008-5472.22382369
https://doi.org/10.1158/0008-5472.22382369
Autor:
Ugo Boggi, Henk M. Verheul, Daniela Campani, Romano Danesi, Alfredo Falcone, Annemieke Groen, Luca E. Pollina, Leticia G. Leon, Enrico Vasile, Leyla A. Erozenci, Marco Del Chiaro, Godefridus J. Peters, Niccola Funel, Elisa Giovannetti
MicroRNA-21 (miR-21) was reported to be overexpressed and contributes to invasion and gemcitabine resistance in pancreatic ductal adenocarcinoma (PDAC). The aim of this study was to evaluate whether miR-21 expression was associated with the overall s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9176c4b2456947eb33f838f0f2daa55c
https://doi.org/10.1158/0008-5472.c.6500180
https://doi.org/10.1158/0008-5472.c.6500180
Autor:
Jorn L. J. C. Assmann, Leticia G. Leon, Christiaan J. Stavast, Sanne E. van den Bogaerdt, Joyce Schilperoord-Vermeulen, Yorick Sandberg, Mar Bellido, Stefan J. Erkeland, David J. Feith, Thomas P. Loughran Jr, Anton W. Langerak
Publikováno v:
Leukemia, 36. Nature Publishing Group
Leukemia, 36(4), 983-993. Nature Publishing Group
Leukemia, 36(4), 983-993. Nature Publishing Group
T-LGL cells arise as a consequence of chronic antigenic stimulation and inflammation and thrive because of constitutive activation of the STAT3 and ERK pathway. Notably, in 40% of patients, constitutive STAT3 activation is due to STAT3 activating mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcbe792e0080c94f752304297c31470b
https://pure.eur.nl/en/publications/5f9453c3-f066-447b-80af-1c45f5f46d92
https://pure.eur.nl/en/publications/5f9453c3-f066-447b-80af-1c45f5f46d92