Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Leticia G. Leon"'
Autor:
Stefan J. Erkeland, Christiaan J. Stavast, Joyce Schilperoord-Vermeulen, Giada Dal Collo, Harmen J.G. van de Werken, Leticia G. Leon, Antoinette van Hoven-Beijen, Iris van Zuijen, Yvonne M. Mueller, Eric M. Bindels, Dick de Ridder, Mies C. Kappers-Klunne, Kirsten van Lom, Vincent H.J. van der Velden, Anton W. Langerak
Publikováno v:
Haematologica, Vol 107, Iss 1 (2021)
T-cell prolymphocytic leukemia (T-PLL) is mostly characterized by aberrant expansion of small- to medium-sized prolymphocytes with a mature post-thymic phenotype, high aggressiveness of the disease and poor prognosis. However, T-PLL is more heterogen
Externí odkaz:
https://doaj.org/article/c51dcad216b44704bc99e3de44c2cf7a
Autor:
Ruud W.J. Meijers, Alice F. Muggen, Leticia G. Leon, Maaike de Bie, Jacques J.M. van Dongen, Rudi W. Hendriks, Anton W. Langerak
Publikováno v:
Haematologica, Vol 105, Iss 1 (2020)
Chronic lymphocytic leukemia (CLL) is a disease with heterogeneous clinical and biological characteristics. Differences in Ca2+ levels among cases, both basal and upon B-cell receptor (BCR) stimulation, may reflect heterogeneity in the pathogenesis d
Externí odkaz:
https://doaj.org/article/c0957c08f15f48cc916d717b2d1088c7
Autor:
Lodewijk J. A. Toonen, Maurice Overzier, Melvin M. Evers, Leticia G. Leon, Sander A. J. van der Zeeuw, Hailiang Mei, Szymon M. Kielbasa, Jelle J. Goeman, Kristina M. Hettne, Olafur Th. Magnusson, Marion Poirel, Alexandre Seyer, Peter A. C. ‘t Hoen, Willeke M. C. van Roon-Mom
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-18 (2018)
Abstract Background Spinocerebellar ataxia type 3 (SCA3) is a progressive neurodegenerative disorder caused by expansion of the polyglutamine repeat in the ataxin-3 protein. Expression of mutant ataxin-3 is known to result in transcriptional dysregul
Externí odkaz:
https://doaj.org/article/cf4ff2d151824bce86e17f157244572b
Autor:
Hector Tejeda-Mora, Leticia G. Leon, Jeroen Demmers, Carla C. Baan, Marlies E. J. Reinders, Bertram Bleck, Eleuterio Lombardo, Ana Merino, Martin J. Hoogduijn
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 12935 (2021)
Extracellular vesicles (EV) derived from mesenchymal stromal cells (MSC) are a potential therapy for immunological and degenerative diseases. However, large-scale production of EV free from contamination by soluble proteins is a major challenge. The
Externí odkaz:
https://doaj.org/article/c9d3b73d969648ef8ef479fba48943fe
Autor:
Daniela Massihnia, Amir Avan, Niccola Funel, Mina Maftouh, Anne van Krieken, Carlotta Granchi, Rajiv Raktoe, Ugo Boggi, Babette Aicher, Filippo Minutolo, Antonio Russo, Leticia G. Leon, Godefridus J. Peters, Elisa Giovannetti
Publikováno v:
Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-17 (2017)
Abstract Background There is increasing evidence of a constitutive activation of Akt in pancreatic ductal adenocarcinoma (PDAC), associated with poor prognosis and chemoresistance. Therefore, we evaluated the expression of phospho-Akt in PDAC tissues
Externí odkaz:
https://doaj.org/article/2d4ba8f27dcf4bd8ba06725e5e44ca29
Autor:
Iris L. A. Bodewes, Peter J. van der Spek, Leticia G. Leon, Annemarie J. M. Wijkhuijs, Cornelia G. van Helden-Meeuwsen, Liselotte Tas, Marco W. J. Schreurs, Paul L. A. van Daele, Peter D. Katsikis, Marjan A. Versnel
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Background: Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease, where patients often suffer from fatigue. Biological pathways underlying fatigue are unknown. In this study aptamer-based SOMAscan technology is used to identify potentia
Externí odkaz:
https://doaj.org/article/46734dad477b4401b0089d6c67ed3791
Autor:
Rocco Sciarrillo, Anna Wojtuszkiewicz, Irsan E. Kooi, Leticia G. Leon, Edwin Sonneveld, Roland P. Kuiper, Gerrit Jansen, Elisa Giovannetti, Gertjan J.L. Kaspers, Jacqueline Cloos
Publikováno v:
Cancers, Vol 12, Iss 3, p 723 (2020)
Glucocorticoid (GC) resistance is a crucial determinant of inferior response to chemotherapy in pediatric acute lymphoblastic leukemia (ALL); however, molecular mechanisms underlying this phenomenon are poorly understood. Deregulated splicing is a co
Externí odkaz:
https://doaj.org/article/5c2ddf53d02f4452a6e104c68207f876
Autor:
Elena Galvani, Elisa Giovannetti, Francesca Saccani, Andrea Cavazzoni, Leticia G. Leon, Henk Dekker, Roberta Alfieri, Caterina Carmi, Marco Mor, Andrea Ardizzoni, Pier Giorgio Petronini, Godefridus J. Peters
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 1, Pp 61-72 (2013)
Overcoming the emergence of acquired resistance to clinically approved epidermal growth factor receptor (EGFR) inhibitors is a major challenge in the treatment of advanced non–small cell lung cancer (NSCLC). The aim of this study was to investigate
Externí odkaz:
https://doaj.org/article/367d37976e004f8fb81e5fe6353c68fd
Autor:
Ugo Boggi, Henk M. Verheul, Daniela Campani, Romano Danesi, Alfredo Falcone, Annemieke Groen, Luca E. Pollina, Leticia G. Leon, Enrico Vasile, Leyla A. Erozenci, Marco Del Chiaro, Godefridus J. Peters, Niccola Funel, Elisa Giovannetti
Supplementary Methods from MicroRNA-21 in Pancreatic Cancer: Correlation with Clinical Outcome and Pharmacologic Aspects Underlying Its Role in the Modulation of Gemcitabine Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eb3410ac8abe5aa75f4a87803809e30
https://doi.org/10.1158/0008-5472.22382375.v1
https://doi.org/10.1158/0008-5472.22382375.v1
Autor:
Ugo Boggi, Henk M. Verheul, Daniela Campani, Romano Danesi, Alfredo Falcone, Annemieke Groen, Luca E. Pollina, Leticia G. Leon, Enrico Vasile, Leyla A. Erozenci, Marco Del Chiaro, Godefridus J. Peters, Niccola Funel, Elisa Giovannetti
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Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff0b1a10a44e00fde73988f00c0c567
https://doi.org/10.1158/0008-5472.22382369
https://doi.org/10.1158/0008-5472.22382369