Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Leticia G Leon"'
Autor:
Manzhi Zhao, Caoimhe H Kiernan, Christopher J Stairiker, Jennifer L Hope, Leticia G Leon, Marjan van Meurs, Inge Brouwers-Haspels, Ruben Boers, Joachim Boers, Joost Gribnau, Wilfred F J van IJcken, Eric M Bindels, Remco M Hoogenboezem, Stefan J Erkeland, Yvonne M Mueller, Peter D Katsikis
Publikováno v:
PLoS Pathogens, Vol 16, Iss 6, p e1008555 (2020)
Exhaustion is a dysfunctional state of cytotoxic CD8+ T cells (CTL) observed in chronic infection and cancer. Current in vivo models of CTL exhaustion using chronic viral infections or cancer yield very few exhausted CTL, limiting the analysis that c
Externí odkaz:
https://doaj.org/article/0638732910034e3dbdc1bc9fe44b7d9d
Autor:
Christopher J Stairiker, Marjan van Meurs, Leticia G Leon, A A Brouwers-Haspels, Laurine Rijsbergen, Yvonne M Mueller, Peter D Katsikis
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0236195 (2020)
During infection, viruses enter susceptible host cells in order to replicate their components for production of new virions. In the process of infection, the gene expression of infected cells undergoes changes because of the production of viral compo
Externí odkaz:
https://doaj.org/article/a76eed523d8b44219bad60f7db5aa876
Autor:
Ogan K Kumova, Adam J Fike, Jillian L Thayer, Linda T Nguyen, Joshua Chang Mell, Judy Pascasio, Christopher Stairiker, Leticia G Leon, Peter D Katsikis, Alison J Carey
Publikováno v:
PLoS Pathogens, Vol 15, Iss 10, p e1008072 (2019)
Respiratory viral infections contribute substantially to global infant losses and disproportionately affect preterm neonates. Using our previously established neonatal murine model of influenza infection, we demonstrate that three-day old mice are ex
Externí odkaz:
https://doaj.org/article/f901ee8cfd604a21bde3c4e6fb64d9a9
Autor:
Elisa Giovannetti, Arjan van der Velde, Niccola Funel, Enrico Vasile, Vittorio Perrone, Leticia G Leon, Nelide De Lio, Amir Avan, Sara Caponi, Luca E Pollina, Valentina Gallá, Hiroko Sudo, Alfredo Falcone, Daniela Campani, Ugo Boggi, Godefridus J Peters
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49145 (2012)
BackgroundOnly a subset of radically resected pancreatic ductal adenocarcinoma (PDAC) patients benefit from chemotherapy, and identification of prognostic factors is warranted. Recently miRNAs emerged as diagnostic biomarkers and innovative therapeut
Externí odkaz:
https://doaj.org/article/78d81e5485f2461cb502a7b869c679ef
Autor:
Jin-Hyeok Hwang, Johannes Voortman, Elisa Giovannetti, Seth M Steinberg, Leticia G Leon, Yong-Tae Kim, Niccola Funel, Joo Kyung Park, Min A Kim, Gyeong Hoon Kang, Sun-Whe Kim, Marco Del Chiaro, Godefridus J Peters, Giuseppe Giaccone
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10630 (2010)
Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis. The high risk of recurrence following surgical resection provides the rationale for adjuvant therapy. However, only a subset of patients benefit from adjuvant therapy. Identification of
Externí odkaz:
https://doaj.org/article/281cc288c786485ab873da9b3573edd6
Autor:
Stefan J. Erkeland, Christiaan J. Stavast, Joyce Schilperoord-Vermeulen, Giada Dal Collo, Harmen J.G. van de Werken, Leticia G. Leon, Antoinette van Hoven-Beijen, Iris van Zuijen, Yvonne M. Mueller, Eric M. Bindels, Dick de Ridder, Mies C. Kappers-Klunne, Kirsten van Lom, Vincent H.J. van der Velden, Anton W. Langerak
Publikováno v:
Haematologica, Vol 107, Iss 1 (2021)
T-cell prolymphocytic leukemia (T-PLL) is mostly characterized by aberrant expansion of small- to medium-sized prolymphocytes with a mature post-thymic phenotype, high aggressiveness of the disease and poor prognosis. However, T-PLL is more heterogen
Externí odkaz:
https://doaj.org/article/c51dcad216b44704bc99e3de44c2cf7a
Autor:
Ruud W.J. Meijers, Alice F. Muggen, Leticia G. Leon, Maaike de Bie, Jacques J.M. van Dongen, Rudi W. Hendriks, Anton W. Langerak
Publikováno v:
Haematologica, Vol 105, Iss 1 (2020)
Chronic lymphocytic leukemia (CLL) is a disease with heterogeneous clinical and biological characteristics. Differences in Ca2+ levels among cases, both basal and upon B-cell receptor (BCR) stimulation, may reflect heterogeneity in the pathogenesis d
Externí odkaz:
https://doaj.org/article/c0957c08f15f48cc916d717b2d1088c7
Autor:
Lodewijk J. A. Toonen, Maurice Overzier, Melvin M. Evers, Leticia G. Leon, Sander A. J. van der Zeeuw, Hailiang Mei, Szymon M. Kielbasa, Jelle J. Goeman, Kristina M. Hettne, Olafur Th. Magnusson, Marion Poirel, Alexandre Seyer, Peter A. C. ‘t Hoen, Willeke M. C. van Roon-Mom
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-18 (2018)
Abstract Background Spinocerebellar ataxia type 3 (SCA3) is a progressive neurodegenerative disorder caused by expansion of the polyglutamine repeat in the ataxin-3 protein. Expression of mutant ataxin-3 is known to result in transcriptional dysregul
Externí odkaz:
https://doaj.org/article/cf4ff2d151824bce86e17f157244572b
Autor:
Iris L. A. Bodewes, Peter J. van der Spek, Leticia G. Leon, Annemarie J. M. Wijkhuijs, Cornelia G. van Helden-Meeuwsen, Liselotte Tas, Marco W. J. Schreurs, Paul L. A. van Daele, Peter D. Katsikis, Marjan A. Versnel
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Background: Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease, where patients often suffer from fatigue. Biological pathways underlying fatigue are unknown. In this study aptamer-based SOMAscan technology is used to identify potentia
Externí odkaz:
https://doaj.org/article/46734dad477b4401b0089d6c67ed3791
Autor:
Ugo Boggi, Henk M. Verheul, Daniela Campani, Romano Danesi, Alfredo Falcone, Annemieke Groen, Luca E. Pollina, Leticia G. Leon, Enrico Vasile, Leyla A. Erozenci, Marco Del Chiaro, Godefridus J. Peters, Niccola Funel, Elisa Giovannetti
Supplementary Methods from MicroRNA-21 in Pancreatic Cancer: Correlation with Clinical Outcome and Pharmacologic Aspects Underlying Its Role in the Modulation of Gemcitabine Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eb3410ac8abe5aa75f4a87803809e30
https://doi.org/10.1158/0008-5472.22382375.v1
https://doi.org/10.1158/0008-5472.22382375.v1
