Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Leticia Fernandez-Rubio"'
Autor:
Luisa Chocarro, Ester Blanco, Leticia Fernandez-Rubio, Maider Garnica, Miren Zuazo, Maria Jesus Garcia, Ana Bocanegra, Miriam Echaide, Colette Johnston, Carolyn J Edwards, James Legg, Andrew J Pierce, Hugo Arasanz, Gonzalo Fernandez-Hinojal, Ruth Vera, Karina Ausin, Enrique Santamaria, Joaquin Fernandez-Irigoyen, Grazyna Kochan, David Escors
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 8, Pp 1791-1816 (2024)
Abstract Many cancer patients do not benefit from PD-L1/PD-1 blockade immunotherapies. PD-1 and LAG-3 co-upregulation in T-cells is one of the major mechanisms of resistance by establishing a highly dysfunctional state in T-cells. To identify shared
Externí odkaz:
https://doaj.org/article/28ff1b0ab6c0455fbce072272578f5f4
Autor:
David Escors, Ana Bocanegra, Luisa Chocarro, Ester Blanco, Sergio Piñeiro-Hermida, Maider Garnica, Leticia Fernandez-Rubio, Ruth Vera, Hugo Arasanz, Grazyna Kochan
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13241 (2022)
PD-L1/PD-1 blockade immunotherapy has changed the therapeutic approaches for the treatment of many cancers. Nevertheless, the mechanisms underlying its efficacy or treatment failure are still unclear. Proficient systemic immunity seems to be a prereq
Externí odkaz:
https://doaj.org/article/9368ea6f30dc49aeb278620d161b8a4f
Autor:
Maider Garnica, Anna Aiello, Mattia Emanuela Ligotti, Giulia Accardi, Hugo Arasanz, Ana Bocanegra, Ester Blanco, Anna Calabrò, Luisa Chocarro, Miriam Echaide, Grazyna Kochan, Leticia Fernandez-Rubio, Pablo Ramos, Fanny Pojero, Nahid Zareian, Sergio Piñeiro-Hermida, Farzin Farzaneh, Giuseppina Candore, Calogero Caruso, David Escors
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9797 (2022)
The number of people that are 65 years old or older has been increasing due to the improvement in medicine and public health. However, this trend is not accompanied by an increase in quality of life, and this population is vulnerable to most illnesse
Externí odkaz:
https://doaj.org/article/8d072a5d97a54a0ca38c20e4d599476f
Autor:
Anna Aiello, Mattia Emanuela Ligotti, Maider Garnica, Giulia Accardi, Anna Calabrò, Fanny Pojero, Hugo Arasanz, Ana Bocanegra, Ester Blanco, Luisa Chocarro, Miriam Echaide, Leticia Fernandez-Rubio, Pablo Ramos, Sergio Piñeiro-Hermida, Grazyna Kochan, Nahid Zareian, Farzin Farzaneh, David Escors, Calogero Caruso, Giuseppina Candore
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9880 (2022)
Vaccination, being able to prevent millions of cases of infectious diseases around the world every year, is the most effective medical intervention ever introduced. However, immunosenescence makes vaccines less effective in providing protection to ol
Externí odkaz:
https://doaj.org/article/1ed714b6d4e24c50b14514e85aef022e
Autor:
Luisa Chocarro, Leticia Fernandez-Rubio, María Jesús García-Granda, Ester Blanco, Ana Bocanegra, Miriam Echaide, Maider Garnica, Miren Zuazo, Colette Johnston, Carolyn J. Edwards, James Legg, Andrew J Pierce, Hugo Arasanz, Ruth Vera, Karina Ausin, Enrique Santamaría, Joaquín Fernández-Irigoyen, Grazyna Kochan, David Escors
A significant number of cancer patients do not benefit from PD-L1/PD-1 blockade immunotherapies. PD-1 and LAG-3 co-upregulation in T-cells is one of the major mechanisms of resistance by establishing a highly dysfunctional state in T-cells. To identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d848313fcb6f18fa869f1a6b34bf72b7
https://doi.org/10.1101/2023.03.10.23287087
https://doi.org/10.1101/2023.03.10.23287087
Autor:
Derek A Wainwright, Aurelio Hernández-Laín, Maria E Rodriguez-Ruiz, Olaya de Dios, Carlos E De Andrea, Angel Pérez-Nuñez, Diego Megías, M Angeles Ramírez-González, Irene Gómez-Soria, Berta Segura-Collar, Juliana Manosalva, Leticia Fernández-Rubio, Juan M Sepúlveda-Sánchez, Ricardo Gargini, Pilar Sánchez-Gómez
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 8 (2024)
Background Activating and inhibitory receptors of natural killer (NK) cells such as NKp, NKG2, or CLEC are highly relevant to cold tumors including glioblastoma (GBM). Here, we aimed to characterize the expression of these receptors in GBM to gain in
Externí odkaz:
https://doaj.org/article/04d1b93182b748a8b6bc49cb908fda23
Autor:
Hugo Arasanz, Luisa Chocarro, Leticia Fernández-Rubio, Ester Blanco, Ana Bocanegra, Miriam Echaide, Ibone Labiano, Ana Elsa Huerta, Maria Alsina, Ruth Vera, David Escors, Grazyna Kochan
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 9855 (2023)
Bispecific antibodies are a promising type of therapy for the treatment of cancer due to their ability to simultaneously inhibit different proteins playing a role in cancer progression. The development in lung cancer has been singularly intense becau
Externí odkaz:
https://doaj.org/article/2597e759acea40d5afa9204115f4270d
Autor:
Ester Blanco, Luisa Chocarro, Leticia Fernández-Rubio, Ana Bocanegra, Hugo Arasanz, Miriam Echaide, Maider Garnica, Sergio Piñeiro-Hermida, Grazyna Kochan, David Escors
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2676 (2023)
Immunotherapies based on immune checkpoint blockade have shown remarkable clinical outcomes and durable responses in patients with many tumor types. Nevertheless, these therapies lack efficacy in most cancer patients, even causing severe adverse even
Externí odkaz:
https://doaj.org/article/da112a495cf44504969175a9ad0558f2
Autor:
Luisa Chocarro, Ester Blanco, Leticia Fernández-Rubio, Hugo Arasanz, Ana Bocanegra, Miriam Echaide, Maider Garnica, Pablo Ramos, Sergio Piñeiro-Hermida, Ruth Vera, Grazyna Kochan, David Escors
Publikováno v:
Biomedicines, Vol 10, Iss 12, p 3035 (2022)
Chimeric antigen receptor (CAR)-T adoptive cell therapy is one of the most promising advanced therapies for the treatment of cancer, with unprecedented outcomes in haematological malignancies. However, it still lacks efficacy in solid tumours, possib
Externí odkaz:
https://doaj.org/article/5127199687ab464095c15c2b22495ba0
Autor:
Luisa Chocarro, Ana Bocanegra, Ester Blanco, Leticia Fernández-Rubio, Hugo Arasanz, Miriam Echaide, Maider Garnica, Pablo Ramos, Sergio Piñeiro-Hermida, Ruth Vera, David Escors, Grazyna Kochan
Publikováno v:
Cells, Vol 11, Iss 15, p 2351 (2022)
Immune checkpoint inhibitors (ICIs) have revolutionized medical practice in oncology since the FDA approval of the first ICI 11 years ago. In light of this, Lymphocyte-Activation Gene 3 (LAG-3) is one of the most important next-generation immune chec
Externí odkaz:
https://doaj.org/article/daeda1afba8b4128981210ceb30080c2