Výsledky vyhledávání - "Leticia De Mattos- Arruda"

Akademický článek

Converging and evolving immuno-genomic routes toward immune escape in breast cancer

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Abstract The interactions between tumor and immune cells along the course of breast cancer progression remain largely unknown. Here, we extensively characterize multiple sequential and parallel multiregion tumor and blood specimens of an index patien

Externí odkaz: https://doaj.org/article/14cae652f3b14f88b2b7c2b80f375b63

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Akademický článek

Virus-like particle-mediated delivery of structure-selected neoantigens demonstrates immunogenicity and antitumoral activity in mice

Publikováno v: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-14 (2024)

Abstract Background Neoantigens are patient- and tumor-specific peptides that arise from somatic mutations. They stand as promising targets for personalized therapeutic cancer vaccines. The identification process for neoantigens has evolved with the

Externí odkaz: https://doaj.org/article/83a923e41a4c4f16982d7a9a094b4b9c

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Akademický článek

The temporal mutational and immune tumour microenvironment remodelling of HER2-negative primary breast cancers

Publikováno v: npj Breast Cancer, Vol 7, Iss 1, Pp 1-10 (2021)

Abstract The biology of breast cancer response to neoadjuvant therapy is underrepresented in the literature and provides a window-of-opportunity to explore the genomic and microenvironment modulation of tumours exposed to therapy. Here, we characteri

Externí odkaz: https://doaj.org/article/206a008b2ff14604b0c18a4e4d55bbec

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Akademický článek

Integrating Biological Advances Into the Clinical Management of Breast Cancer Related Lymphedema

Autor: Marco Invernizzi, Gianluca Lopez, Anna Michelotti, Konstantinos Venetis, Elham Sajjadi, Leticia De Mattos-Arruda, Michele Ghidini, Letterio Runza, Alessandro de Sire, Renzo Boldorini, Nicola Fusco

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

Breast cancer-related lymphedema (BCRL) occurs in a significant number of breast cancer survivors as a consequence of the axillary lymphatics' impairment after therapy (mainly axillary surgery and irradiation). Despite the recent achievements in the

Externí odkaz: https://doaj.org/article/4b783b2c683c4cd2a900b5b89753d093

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Akademický článek

Intersect-then-combine approach: improving the performance of somatic variant calling in whole exome sequencing data using multiple aligners and callers

Autor: Maurizio Callari, Stephen-John Sammut, Leticia De Mattos-Arruda, Alejandra Bruna, Oscar M. Rueda, Suet-Feung Chin, Carlos Caldas

Publikováno v: Genome Medicine, Vol 9, Iss 1, Pp 1-11 (2017)

Abstract Bioinformatic analysis of genomic sequencing data to identify somatic mutations in cancer samples is far from achieving the required robustness and standardisation. In this study we generated a whole exome sequencing benchmark dataset using

Externí odkaz: https://doaj.org/article/7488b73db73f445ba7052efa8ade4e0d

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Akademický článek

The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer

Publikováno v: Cell Reports, Vol 27, Iss 9, Pp 2690-2708.e10 (2019)

Summary: The detailed molecular characterization of lethal cancers is a prerequisite to understanding resistance to therapy and escape from cancer immunoediting. We performed extensive multi-platform profiling of multi-regional metastases in autopsie

Externí odkaz: https://doaj.org/article/caa33a84a1a642cdaf3f8314c1e4dd94

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