New Platinum(II) Triazole Thiosemicarbazone Complexes: Analysis of Their Reactivity and Potential Antitumoral Action

Autor: Eva J Faraco, Ana I. Matesanz, Leticia Cubo, Jorge M. Herrero, Adoración G. Quiroga

Publikováno v: ChemBioChem. 21:1226-1232

The synthesis and characterization of three new platinum complexes, with 3,5-diacetyl-1,2,4-triazole bis(4-N-isopropylthiosemicarbazone) as a ligand, are reported. The specific conditions under which solvent coordination takes place are reported and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb7dca8cfc2a510999de72d24c532a3
https://doi.org/10.1002/cbic.201900545

Photoactivation of trans diamine platinum complexes in aqueous solution and effect on reactivity towards nucleotides

Autor: Peter J. Sadler, Carmen Navarro-Ranninger, Leticia Cubo, Ana M. Pizarro, Adoración G. Quiroga, Luca Salassa

Publikováno v: Journal of Inorganic Biochemistry. 104:909-918

We show that UVA irradiation (365 nm) of the Pt-IV complex trans,trans,trans-[(PtCl2)-Cl-IV(OH)(2)(dimethylamine) (isopropylamine)] (1), induces reduction to Pt-II photoproducts. For the mixed amine Pt-II complex, trans[(PtCl2)-Cl-II(isopropylamine)(

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::229d1078fa8207d1e5809d13f6d30e45
https://doi.org/10.1016/j.jinorgbio.2010.04.009

Isolation of an Intermediate in the Platination of p ‐Nitroacetophenone 4‐Methylthiosemicarbazone: Potential Application as an Antitumor Drug

Autor: Amancio Carnero, Carmen Navarro-Ranninger, Leticia Cubo, Victoria Moneo, Adoración G. Quiroga, Pablo J. Sanz Miguel

Publikováno v: European Journal of Inorganic Chemistry. 2008:1183-1187

The investigation of the formation and reactivity of Pd and Pt thiosemicarbazone complexes has revealed an unstudied intermediate derived from p-nitroacetophenone 4-methylthiosemicabazone (L1H2). The L1H2 ligand leads to a new complex [Pt(L1)(L1H2)]

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48105064ce044ba943985332de2b08df
https://doi.org/10.1002/ejic.200800003

Trans platinum complexes design: One novel water soluble oxime derivative that contains aliphatic amines in trans configuration

Autor: Leticia Cubo, Patricio Aller, Adoración G. Quiroga, Carmen Navarro-Ranninger, Elena de Blas

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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7 páginas, 5 figuras, 1 tabla -- PAGS nros. 104-110
In an attempt to design new antitumoral drugs based on transplatin complexes, we determined the experimental conditions for the preparation of trans-[Pt((CH3)2CNOH)((CH3)2CHNH2)Cl2], and solve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98bc7c4ea5345188740e2692f2e2c460
https://doi.org/10.1016/j.jinorgbio.2006.08.012

Assembly of palladium(II) and platinum(II) metallo-rectangles with a guanosine-substituted terpyridine and study of their interactions with quadruplex DNA

Autor: Leticia Cubo, Ramon Vilar, Valérie Gabelica, Sushobhan Ghosh, Oscar Mendoza, Frédéric Rosu, Andrew J. P. White

Publikováno v: Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2014, 20 (16), pp.4772-4779. ⟨10.1002/chem.201304905⟩
Chemistry-A European Journal, 2014, 20 (16), pp.4772-4779. ⟨10.1002/chem.201304905⟩

International audience; Two novel [2+2] metallo-assemblies based on a guanosine-substituted terpyridine ligand (1) coordinated to palladium(II) (2a) and platinum(II) (2b) are reported. These supramolecular assemblies have been fully characterized by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3acee32662a5a5806bf24295a05ab25c
https://pubmed.ncbi.nlm.nih.gov/24596127