Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Leticia Campo"'
Autor:
Elizabeth J. Brown, Leire Balaguer-Lluna, Adam P. Cribbs, Martin Philpott, Leticia Campo, Molly Browne, Jong Fu Wong, Udo Oppermann, Ángel M. Carcaboso, Alex N. Bullock, Gillian Farnie
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract H3K27-altered Diffuse Midline Glioma (DMG) is a universally fatal paediatric brainstem tumour. The prevalent driver mutation H3K27M creates a unique epigenetic landscape that may also establish therapeutic vulnerabilities to epigenetic inhib
Externí odkaz:
https://doaj.org/article/cd300eaf757540c2bae8198462204942
Autor:
Anja L Frei, Anthony McGuigan, Ritik RAK Sinha, Mark A Glaire, Faiz Jabbar, Luciana Gneo, Tijana Tomasevic, Andrea Harkin, Tim J Iveson, Mark Saunders, Karin Oein, Noori Maka, Francesco Pezella, Leticia Campo, Jennifer Hay, Joanne Edwards, Owen J Sansom, Caroline Kelly, Ian Tomlinson, Wanja Kildal, Rachel S Kerr, David J Kerr, Håvard E Danielsen, Enric Domingo, TransSCOT Consortium, David N Church, Viktor H Koelzer
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 9, Iss 6, Pp 449-463 (2023)
Abstract Multiplex immunofluorescence (mIF) imaging can provide comprehensive quantitative and spatial information for multiple immune markers for tumour immunoprofiling. However, application at scale to clinical trial samples sourced from multiple i
Externí odkaz:
https://doaj.org/article/d2fd350d290249e6b38f3b09f966ff54
Autor:
Stephen W. Booth, Toby A. Eyre, John Whittaker, Leticia Campo, Lai Mun Wang, Elizabeth Soilleux, Daniel Royston, Gabrielle Rees, Murali Kesavan, Catherine Hildyard, Farasat Kazmi, Nick La Thangue, David Kerr, Mark R. Middleton, Graham P. Collins
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-10 (2021)
Abstract Background This Phase 2a dose expansion study was performed to assess the safety, tolerability and preliminary efficacy of the maximum tolerated dose of the oral histone de-acetylase (HDAC) inhibitor CXD101 in patients with relapsed / refrac
Externí odkaz:
https://doaj.org/article/ed0569a0654b401a969430ba23e234a6
Autor:
Paul Christopher Lyon, Visa Suomi, Philip Jakeman, Leticia Campo, Constantin Coussios, Robert Carlisle
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Abstract Triggered release and targeted drug delivery of potent anti-cancer agents using hyperthermia-mediated focused-ultrasound (FUS) is gaining momentum in the clinical setting. In early phase studies, tissue biopsy samples may be harvested to ass
Externí odkaz:
https://doaj.org/article/77c829b338cb49c9a1408af1c8c3576a
Autor:
Amélie Viratham Pulsawatdi, Stephanie G. Craig, Victoria Bingham, Kris McCombe, Matthew P. Humphries, Seedevi Senevirathne, Susan D. Richman, Phil Quirke, Leticia Campo, Enric Domingo, Timothy S. Maughan, Jacqueline A. James, Manuel Salto‐Tellez
Publikováno v:
Molecular Oncology, Vol 14, Iss 10, Pp 2384-2402 (2020)
Multiplex immunofluorescence is a powerful tool for the simultaneous detection of tissue‐based biomarkers, revolutionising traditional immunohistochemistry. The Opal methodology allows up to eight biomarkers to be measured concomitantly without cro
Externí odkaz:
https://doaj.org/article/ddaedcd62c55444cbbab846a80836163
Autor:
Mara Artibani, Kenta Masuda, Zhiyuan Hu, Pascal C. Rauher, Garry Mallett, Nina Wietek, Matteo Morotti, Kay Chong, Mohammad KaramiNejadRanjbar, Christos E. Zois, Sunanda Dhar, Salma El-Sahhar, Leticia Campo, Sarah P. Blagden, Stephen Damato, Pubudu N. Pathiraja, Shibani Nicum, Fergus Gleeson, Alexandros Laios, Abdulkhaliq Alsaadi, Laura Santana Gonzalez, Takeshi Motohara, Ashwag Albukhari, Zhen Lu, Robert C. Bast Jr., Adrian L. Harris, Christer S. Ejsing, Robin W. Klemm, Christopher Yau, Tatjana Sauka-Spengler, Ahmed Ashour Ahmed
Publikováno v:
JCI Insight, Vol 6, Iss 11 (2021)
Similar to tumor-initiating cells (TICs), minimal residual disease (MRD) is capable of reinitiating tumors and causing recurrence. However, the molecular characteristics of solid tumor MRD cells and drivers of their survival have remained elusive. He
Externí odkaz:
https://doaj.org/article/aed4f3377d6c477db1f5a1a0d72b84ea
Autor:
Yiyan Zheng, Ritika Sethi, Lingegowda S. Mangala, Charlotte Taylor, Juliet Goldsmith, Ming Wang, Kenta Masuda, Eli M. Carrami, David Mannion, Fabrizio Miranda, Sandra Herrero-Gonzalez, Karin Hellner, Fiona Chen, Abdulkhaliq Alsaadi, Ashwag Albukhari, Donatien Chedom Fotso, Christopher Yau, Dahai Jiang, Sunila Pradeep, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Stefan Knapp, Nathanael S. Gray, Leticia Campo, Kevin A. Myers, Sunanda Dhar, David Ferguson, Robert C. Bast, Anil K. Sood, Frank von Delft, Ahmed Ashour Ahmed
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/2005bec4130b42fcbb14be00909fa2b7
Autor:
Paul C. Lyon, BSc, MSc, MRCS, MRes, DPhil, Helen Winter, BSc, MBBS, MSc, MRCP, FRACP, Karin Herbschleb, MRCP, Leticia Campo, Diploma, Robert Carlisle, PhD, Feng Wu, MD, PhD, Robert Goldin, MD, MEd, FRCPath, Constantin C. Coussios, PhD, Mark R. Middleton, BA, MA, PhD, FRCP, Fergus V. Gleeson, FRCR, FRCP, Philip Boardman, FRCR, Ricky A. Sharma, MB, BChir, MA, PhD, FRCP, FRCR
Publikováno v:
Radiology Case Reports, Vol 13, Iss 6, Pp 1259-1266 (2018)
Liver metastasis from breast cancer is associated with poor prognosis and is a major cause of early morbidity and mortality. When liver resection is not feasible, minimally invasive directed therapies are considered to attempt to prolong survival. Se
Externí odkaz:
https://doaj.org/article/20f6dd12649d40dc90fb887054b18b43
Autor:
Yiyan Zheng, Ritika Sethi, Lingegowda S. Mangala, Charlotte Taylor, Juliet Goldsmith, Ming Wang, Kenta Masuda, Mohammad Karaminejadranjbar, David Mannion, Fabrizio Miranda, Sandra Herrero-Gonzalez, Karin Hellner, Fiona Chen, Abdulkhaliq Alsaadi, Ashwag Albukhari, Donatien Chedom Fotso, Christopher Yau, Dahai Jiang, Sunila Pradeep, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Stefan Knapp, Nathanael S. Gray, Leticia Campo, Kevin A. Myers, Sunanda Dhar, David Ferguson, Robert C. Bast, Anil K. Sood, Frank von Delft, Ahmed Ashour Ahmed
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Some anticancer drugs target cell microtubules inhibiting mitosis and cell division. Here, the authors show that CRMP2 induces microtubule bundling and that this activity is regulated by the FER kinase, thus providing a rationale for targeting FER in
Externí odkaz:
https://doaj.org/article/3f3066d1a6b14342a99fe65262e6ce95
Autor:
Karin Hellner, Fabrizio Miranda, Donatien Fotso Chedom, Sandra Herrero-Gonzalez, Daniel M. Hayden, Rick Tearle, Mara Artibani, Mohammad KaramiNejadRanjbar, Ruth Williams, Kezia Gaitskell, Samar Elorbany, Ruoyan Xu, Alex Laios, Petronela Buiga, Karim Ahmed, Sunanda Dhar, Rebecca Yu Zhang, Leticia Campo, Kevin A. Myers, María Lozano, María Ruiz-Miró, Sónia Gatius, Alba Mota, Gema Moreno-Bueno, Xavier Matias-Guiu, Javier Benítez, Lorna Witty, Gil McVean, Simon Leedham, Ian Tomlinson, Radoje Drmanac, Jean-Baptiste Cazier, Robert Klein, Kevin Dunne, Robert C. Bast Jr, Stephen H. Kennedy, Bassim Hassan, Stefano Lise, María José Garcia, Brock A. Peters, Christopher Yau, Tatjana Sauka-Spengler, Ahmed Ashour Ahmed
Publikováno v:
EBioMedicine, Vol 10, Iss C, Pp 137-149 (2016)
Current screening methods for ovarian cancer can only detect advanced disease. Earlier detection has proved difficult because the molecular precursors involved in the natural history of the disease are unknown. To identify early driver mutations in o
Externí odkaz:
https://doaj.org/article/48848af61fb0476781413217637a8181