Expression of the human atypical kinase ADCK3 rescues coenzyme Q biosynthesis and phosphorylation of Coq polypeptides in yeast coq8 mutants

Autor: Edward J. Hsieh, UyenPhuong C. Tran, Jia Y. Chen, Catherine F. Clarke, Letian X. Xie, Shota Watanabe, Christopher M. Allan

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1811:348-360

Coenzyme Q (ubiquinone or Q) is a lipid electron and proton carrier in the electron transport chain. In yeast Saccharomyces cerevisiae eleven genes, designated COQ1 through COQ9 , YAH1 and ARH1 , have been identified as being required for Q biosynthe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd55f441d0ce7c84204551d6c9e338c1
https://doi.org/10.1016/j.bbalip.2011.01.009

Resveratrol and para-coumarate serve as ring precursors for coenzyme Q biosynthesis

Autor: Emily Weng, Ohyun Kwon, Letian X. Xie, San Khong, Steven J. Bensinger, Kevin J. Williams, Tristan E. Rose, Catherine F. Clarke, Cuiwen He, Beth N. Marbois

Publikováno v: Journal of lipid research, vol 56, iss 4
Journal of Lipid Research, Vol 56, Iss 4, Pp 909-919 (2015)

Coenzyme Q (Q or ubiquinone) is a redox-active polyisoprenylated benzoquinone lipid essential for electron and proton transport in the mitochondrial respiratory chain. The aromatic ring 4-hydroxybenzoic acid (4HB) is commonly depicted as the sole aro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c4bf7e7e9444f5238554f8fb3d3759d
https://escholarship.org/uc/item/0kj611r6

In vivo accumulation of coenzyme Q biosynthetic intermediates and aminated analogs in the yeast Saccharomyces cerevisiae

Autor: Jeniffer Y. Tang, Letian X. Xie, Fabien Pierrel, Mohammad Ozeir, Mahmoud Hajj Chehade, Jia Y. Chen, Sylvie-Kieffer Jaquinod, Marc Fontecave, Catherine F. Clarke

Publikováno v: Biochimica biophysica acta (BBA)-Bioenergetics
Biochimica biophysica acta (BBA)-Bioenergetics, 2012, 1817, pp.S92-S92. ⟨10.1016/j.bbabio.2012.06.249⟩
Biochimica biophysica acta (BBA)-Bioenergetics, Elsevier, 2012, 1817, pp.S92-S92. ⟨10.1016/j.bbabio.2012.06.249⟩

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1602513658a972b74c01035147595295
https://hal.science/hal-01236935

COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness

Autor: Eva Trevisson, Vanessa Pertegato, Gudrun Nürnberg, Dominik S. Schoeb, Paul D. Killen, Christian Becker, Yehoash Raphael, Holger Prokisch, Neveen A. Soliman, Rannar Airik, Christopher N. Vlangos, Pawaree Saisawat, Toby W. Hurd, Agnès Rötig, Gil Chernin, Andreas Kispert, Virginia Vega-Warner, Leonardo Salviati, Jochen Reiser, Alexis Sloan, Letian X. Xie, Afig Berdeli, Gianpietro Giorgi, Seza ϖzen, Su Q. Wang, Weibin Zhou, Peter Nürnberg, Sevcan A. Bakkaloglu, Mara Doimo, Bugsu Ovunc, Sevgi Mir, Fatih Ozaltin, Stefanie Krick, Shazia Ashraf, Roger C. Wiggins, Martin Zenker, Saskia F. Heeringa, Antje Beissert, Dominik N. Müller, Verena Matejas, Heather M. McLaughlin, Rasheed Gbadegesin, Ziming Ji, Friedhelm Hildebrandt, Takehiro Kusakabe, Moumita Chaki, Carlos Santos-Ocaña, Plácido Navas, Sema Akman, Peter Mundel, Alberto Casarin, Christian Faul, Rezan Topaloglu, Catherine F. Clarke, Aysin Bakkaloglu, Bernward Hinkes

Publikováno v: Heeringa, S F, Chernin, G, Chaki, M, Zhou, W, Sloan, A J, Ji, Z, Xie, L X, Salviati, L, Hurd, T W, Vega-Warner, V, Killen, P D, Raphael, Y, Ashraf, S, Ovunc, B, Schoeb, D S, McLaughlin, H M, Airik, R, Vlangos, C N, Gbadegesin, R, Hinkes, B, Saisawat, P, Trevisson, E, Doimo, M, Casarin, A, Pertegato, V, Giorgi, G, Prokisch, H, Rötig, A, Nürnberg, G, Becker, C, Wang, S, Ozaltin, F, Topaloglu, R, Bakkaloglu, A, Bakkaloglu, S A, Müller, D, Beissert, A, Mir, S, Berdeli, A, Varpizen, S, Zenker, M, Matejas, V, Santos-Ocaña, C, Navas, P, Kusakabe, T, Kispert, A, Akman, S, Soliman, N A, Krick, S, Mundel, P, Reiser, J, Nürnberg, P, Clarke, C F, Wiggins, R C, Faul, C & Hildebrandt, F 2011, ' COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness ', Journal of Clinical Investigation, vol. 121, no. 5, pp. 2013-24 . https://doi.org/10.1172/JCI45693
J. Clin. Invest. 121, 2013-2024 (2011)
Digital.CSIC. Repositorio Institucional del CSIC
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WOS: 000290246800035
PubMed ID: 21540551
Steroid-resistant nephrotic syndrome (SRNS) is a frequent cause of end-stage renal failure. Identification of single-gene causes of SRNS has generated some insights into its pathogenesis; however, ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bbb5227453df1f87059d7143f50a903
https://avesis.gazi.edu.tr/publication/details/eb384aa3-f6ca-4920-9616-08694e2d1695/oai

Focal segmental glomerulosclerosis is associated with a PDSS2 haplotype and, independently, with a decreased content of coenzyme Q10.

Autor: Gasser, David L., Winkler, Cheryl A., Min Peng, Ping An, McKenzie, Louise M., Kirk, Gregory D., Yuchen Shi, Letian X. Xie, Marbois, Beth N., Clarke, Catherine F., Kopp, Jeffrey B.

Publikováno v: American Journal of Physiology: Renal Physiology; Oct2013, Vol. 305 Issue 8, pF1228-F1238, 11p