Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Letian Song"'
Autor:
Letian Song, Shenghua Gao, Bing Ye, Mianling Yang, Yusen Cheng, Dongwei Kang, Fan Yi, Jin-Peng Sun, Luis Menéndez-Arias, Johan Neyts, Xinyong Liu, Peng Zhan
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 1, Pp 87-109 (2024)
The main protease (Mpro) of SARS-CoV-2 is an attractive target in anti-COVID-19 therapy for its high conservation and major role in the virus life cycle. The covalent Mpro inhibitor nirmatrelvir (in combination with ritonavir, a pharmacokinetic enhan
Externí odkaz:
https://doaj.org/article/3f51f2f2ddc7422491491f1bb580fa8a
Autor:
Shenghua Gao, Letian Song, Yusen Cheng, Fabao Zhao, Dongwei Kang, Shu Song, Mianling Yang, Bing Ye, Wei Zhao, Yajie Tang, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 6, Pp 2747-2764 (2023)
Indolylarylsulfones (IASs) are classical HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with a unique scaffold and possess potent antiviral activity. To address the high cytotoxicity and improve safety profiles of IASs, we introduced
Externí odkaz:
https://doaj.org/article/8964cae7904a4512954b69a8af82c05c
Autor:
Shenghua Gao, Tianguang Huang, Letian Song, Shujing Xu, Yusen Cheng, Srinivasulu Cherukupalli, Dongwei Kang, Tong Zhao, Lin Sun, Jian Zhang, Peng Zhan, Xinyong Liu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 2, Pp 581-599 (2022)
Novel therapies are urgently needed to improve global treatment of SARS-CoV-2 infection. Herein, we briefly provide a concise report on the medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors with representative
Externí odkaz:
https://doaj.org/article/42a993d333674950b66d10c6989264d8
Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors
Autor:
Shenghua Gao, Letian Song, Hongtao Xu, Antonios Fikatas, Merel Oeyen, Steven De Jonghe, Fabao Zhao, Lanlan Jing, Dirk Jochmans, Laura Vangeel, Yusen Cheng, Dongwei Kang, Johan Neyts, Piet Herdewijn, Dominique Schols, Peng Zhan, Xinyong Liu
Publikováno v:
Molecules, Vol 28, Iss 1, p 160 (2022)
The Coronavirus Disease 2019 (COVID-19) and dengue fever (DF) pandemics both remain to be significant public health concerns in the foreseeable future. Anti-SARS-CoV-2 drugs and vaccines are both indispensable to eliminate the epidemic situation. Her
Externí odkaz:
https://doaj.org/article/89b6753f327840d6a40932bf3754e640
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202868 (2018)
As a powerful tool for fast and precise genome editing, the CRISPR/Cas9 system has been applied in filamentous fungi to improve the efficiency of genome alteration. However, the method of delivering guide RNA (gRNA) remains a bottleneck in performing
Externí odkaz:
https://doaj.org/article/921ecdce5f6645e6863fde079838dcea
Autor:
Shenghua Gao, Letian Song, Tobias Claff, Molly Woodson, Katharina Sylvester, Lanlan Jing, Renato H. Weiße, Yusen Cheng, Norbert Sträter, Laura Schäkel, Michael Gütschow, Bing Ye, Mianling Yang, Tao Zhang, Dongwei Kang, Karoly Toth, John Tavis, Ann E. Tollefson, Christa E. Müller, Peng Zhan, Xinyong Liu
Publikováno v:
Journal of Medicinal Chemistry. 65:16902-16917
The spread of SARS-CoV-2 keeps threatening human life and health, and small-molecule antivirals are in demand. The main protease (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::271ca8882f9f7b9c5ad53b93c3b5bbee
https://doi.org/10.1021/acs.jmedchem.2c01716
https://doi.org/10.1021/acs.jmedchem.2c01716
Autor:
Shujing Xu, Jian Zhang, Yusen Cheng, Tong Zhao, Xinyong Liu, Tianguang Huang, Lin Sun, Letian Song, Dongwei Kang, Peng Zhan, Shenghua Gao, Srinivasulu Cherukupalli
Publikováno v:
Acta Pharmaceutica Sinica. B
Novel therapies are urgently needed to improve global treatment of SARS-CoV-2 infection. Herein, we briefly provide a concise report on the medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors with representative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bed086534a97edbe615ec38f29a3dbc3
https://doi.org/10.1016/j.apsb.2021.08.027
https://doi.org/10.1016/j.apsb.2021.08.027
Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors
Autor:
Shenghua Gao, Letian Song, Hongtao Xu, Antonios Fikatas, Merel Oeyen, Steven De Jonghe, Fabao Zhao, Lanlan Jing, Dirk Jochmans, Laura Vangeel, Yusen Cheng, Dongwei Kang, Johan Neyts, Piet Herdewijn, Dominique Schols, Peng Zhan, Xinyong Liu
Publikováno v:
Molecules; Volume 28; Issue 1; Pages: 160
The Coronavirus Disease 2019 (COVID-19) and dengue fever (DF) pandemics both remain to be significant public health concerns in the foreseeable future. Anti-SARS-CoV-2 drugs and vaccines are both indispensable to eliminate the epidemic situation. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dab3f9b3c3f2ed8cbf75985fbb973cc
https://lirias.kuleuven.be/handle/20.500.12942/711110
https://lirias.kuleuven.be/handle/20.500.12942/711110
Autor:
Shenghua Gao, Katharina Sylvester, Letian Song, Tobias Claff, Lanlan Jing, Molly Woodson, Renato H. Weiße, Yusen Cheng, Laura Schäkel, Marvin Petry, Michael Gütschow, Anke C. Schiedel, Norbert Sträter, Dongwei Kang, Shujing Xu, Karoly Toth, John Tavis, Ann E. Tollefson, Christa E. Müller, Xinyong Liu, Peng Zhan
Publikováno v:
Journal of medicinal chemistry. 65(19)
The continuous spread of SARS-CoV-2 calls for more direct-acting antiviral agents to combat the highly infectious variants. The main protease (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f21c7153a2aaab01947dfa7685024a7
https://pubmed.ncbi.nlm.nih.gov/36107752
https://pubmed.ncbi.nlm.nih.gov/36107752
Autor:
Shenghua Gao, Yusen Cheng, Shu Song, Letian Song, Fabao Zhao, Shujing Xu, Dongwei Kang, Lin Sun, Ping Gao, Erik De Clercq, Christophe Pannecouque, Xinyong Liu, Peng Zhan
Publikováno v:
European Journal of Medicinal Chemistry. 238:114471
To thoroughly investigate the uncharted chemical space around the entrance channel of HIV-1 reverse transcriptase (RT) and to improve the physicochemical properties, we introduced different spiro ring structures with high Fsp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a9676de07d11a7b81f2f199573ee6d5
https://doi.org/10.1016/j.ejmech.2022.114471
https://doi.org/10.1016/j.ejmech.2022.114471