Zobrazeno 1 - 10
of 20 204
pro vyhledávání: '"Lethality"'
Autor:
Giovanni Buccioli, Carolina Testa, Emanuela Jacchetti, Pietro Pinoli, Stephana Carelli, Stefano Ceri, Manuela T. Raimondi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Statins, widely used cardiovascular drugs that lower cholesterol by inhibiting HMG-CoA reductase, have been increasingly recognized for their potential anticancer properties. This study elucidates the underlying mechanism, revealing that sta
Externí odkaz:
https://doaj.org/article/0c1f53cca6b34826820d8f66486621c7
Publikováno v:
Health Research Policy and Systems, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background Cancer is a major public health challenge globally. However, little is known about the evolution patterns of cancer research communities and the influencing factors of their research capacity and impact, which is affected not only
Externí odkaz:
https://doaj.org/article/3ff220a3d8df4a2589c620f956f33868
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Selective drugs with a relatively narrow spectrum can reduce the side effects of treatments compared to broad-spectrum antibiotics by specifically targeting the pathogens responsible for infection. Furthermore, combating an infectious pathog
Externí odkaz:
https://doaj.org/article/86d6df7c8f854474afb916106d74bcb6
Autor:
Leonardo Gomes da Silva, Italla Maria Pinheiro Bezerra, Gabriella Lima Santos, Luiz Carlos de Abreu
Publikováno v:
Epidemiologia, Vol 5, Iss 2, Pp 250-266 (2024)
At the beginning of December 2019, a new type of coronavirus emerged, SARS-CoV-2. This virus causes COVID-19, a highly contagious disease that can initially present asymptomatically and can also lead to death. Our ecological study goal was to evaluat
Externí odkaz:
https://doaj.org/article/c81c415bf03c49709d9b64fb6ed5f94e
Autor:
Stephan Krieg, Thomas Rohde, Tobias Rausch, Luise Butthof, Lena Wendler-Link, Christoph Eckert, Kai Breuhahn, Bruno Galy, Jan Korbel, Maximilian Billmann, Marco Breinig, Darjus F. Tschaharganeh
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-21 (2024)
Abstract Background Somatic copy number alterations are a hallmark of cancer that offer unique opportunities for therapeutic exploitation. Here, we focused on the identification of specific vulnerabilities for tumors harboring chromosome 8p deletions
Externí odkaz:
https://doaj.org/article/d7c5dfffb2304419945cd7a2bce10c8a
Autor:
Richard Seidu A.
Publikováno v:
Open Medicine, Vol 19, Iss 1, Pp 602-66 (2024)
Glioblastoma multiforme (GBM) is characterized by a high mortality rate, high resistance to cytotoxic chemotherapy, and radiotherapy due to its highly aggressive nature. The pathophysiology of GBM is characterized by multifarious genetic abrasions th
Externí odkaz:
https://doaj.org/article/034128ab27014209b99d7210bb2744a7
Autor:
Natalia Tikhenko, Max Haupt, Jörg Fuchs, Dragan Perovic, Axel Himmelbach, Martin Mascher, Andreas Houben, Twan Rutten, Manuela Nagel, Natalia V. Tsvetkova, Stefanie Sehmisch, Andreas Börner
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The presence of incompatibility alleles in primary amphidiploids constitutes a reproductive barrier in newly synthesized wheat-rye hybrids. To overcome this barrier, the genome stabilization process includes large-scale chromosome rearrangem
Externí odkaz:
https://doaj.org/article/072af3058f14482cbfb11067aea36d71
Autor:
Joseane Elza Tonussi Mendes, Blanca Elena Guerrero Daboin, Tassiane Cristina Morais, Italla Maria Pinheiro Bezerra, Matheus Paiva Emidio Cavalcanti, Andres Ricardo Perez Riera, Matias Noll, Luiz Carlos de Abreu
Publikováno v:
Epidemiologia, Vol 5, Iss 2, Pp 187-199 (2024)
The north region of Brazil is characterized by significant vulnerabilities, notably surpassing national poverty indicators. These disparities exacerbated the impact of respiratory illnesses on the healthcare system during the COVID-19 pandemic, parti
Externí odkaz:
https://doaj.org/article/b0aae0d2e26d4be486821eae80552f53
Autor:
Michael Qwarse, Mainen Julius Moshi, Matobola Joel Mihale, Alphonce Ignace Marealle, Ramadhani Selemani Omari Nondo, Joseph Sempombe, Veronica Mugoyela
Publikováno v:
Research Journal of Pharmacognosy, Vol 11, Iss 2, Pp 37-46 (2024)
Background and objectives: Several wild mushroom species occur in southern Tanzania and are used as food by the local tribes. Experience shows that some of them could contain phytochemical compounds with therapeutic potential for treating various dis
Externí odkaz:
https://doaj.org/article/c4712d64a2ed4af3b9f868012abbb589