Zobrazeno 1 - 10
of 1 244
pro vyhledávání: '"Lethal toxin"'
Autor:
Guan-Ling Lin, Hsin-Hou Chang, Wei-Ting Lin, Yu-Shan Liou, Yi-Ling Lai, Min-Hua Hsieh, Po-Kong Chen, Chi-Yuan Liao, Chi-Chih Tsai, Tso-Fu Wang, Sung-Chao Chu, Jyh-Hwa Kau, Hsin-Hsien Huang, Hui-Ling Hsu, Der-Shan Sun
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 6, p 3102 (2024)
Lethal toxin (LT) is the critical virulence factor of Bacillus anthracis, the causative agent of anthrax. One common symptom observed in patients with anthrax is thrombocytopenia, which has also been observed in mice injected with LT. Our previous st
Externí odkaz:
https://doaj.org/article/6db2c920a4ea4d7583ecc3b2bedaf74a
Development of a New Cell-Based AP-1 Gene Reporter Potency Assay for Anti-Anthrax Toxin Therapeutics
Publikováno v:
Toxins, Vol 15, Iss 9, p 528 (2023)
Anthrax toxin is a critical virulence factor of Bacillus anthracis. The toxin comprises protective antigen (PA) and two enzymatic moieties, edema factor (EF) and lethal factor (LF), forming bipartite lethal toxin (LT) and edema toxin (ET). PA binds c
Externí odkaz:
https://doaj.org/article/69fde52c7f454a98af1800f8f613cc2b
Akademický článek
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Autor:
V. V. Firstova, A. S. Kartseva, M. V. Silkina, M. A. Marin, Ia. O. Muntian, A. K. Ryabko, I. G. Shemyakin
Publikováno v:
Инфекция и иммунитет, Vol 9, Iss 3-4, Pp 495-503 (2019)
Currently, live anthrax vaccine has been used for vaccine prophylaxis in Russia and neighbor countries for seve ral decades, but precise mechanism of post-vaccination protection mechanism remains unclear. Here, we provide data on examining serum anti
Externí odkaz:
https://doaj.org/article/2f65465c0b2849d3b5eff8ad2193e61e
Autor:
Siping Xiong, Tingting Zhou, Feng Zheng, Xudong Liang, Yongping Cao, Chunhui Wang, Zhengqin Feng, Qi Tang, Jin Zhu
Publikováno v:
BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-8 (2019)
Abstract Background Bacillus anthracis causes a highly lethal infectious disease primarily due to toxin-mediated injury. Antibiotics are no longer effective to treat the accumulation of anthrax toxin, thereby new strategies of antibody treatment are
Externí odkaz:
https://doaj.org/article/67c75371874042949038c9a9d7c2c695
Autor:
Qi Tang, Siping Xiong, Xudong Liang, Xingwang Kuai, Yiwen Wang, Changjun Wang, Zhenqing Feng, Jin Zhu
Publikováno v:
BMC Infectious Diseases, Vol 18, Iss 1, Pp 1-8 (2018)
Abstract Background Disease caused by Bacillus anthracis is often accompanied by high mortality primarily due to toxin-mediated injury. In the early disease course, anthrax toxins are secreted; thus, antibiotic use is limited to the early stage. In t
Externí odkaz:
https://doaj.org/article/f98f30d88aac4e1c924930ce0dbad4a6
Akademický článek
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Autor:
Dante A. Suffredini, Xizhong Cui, Dharmvir Jaswal, Kenneth E. Remy, Yan Li, Junfeng Sun, Steven B. Solomon, Yvonne Fitz, Mahtab Moayeri, Stephen Leppla, Peter Q. Eichacker
Publikováno v:
Intensive Care Medicine Experimental, Vol 5, Iss 1, Pp 1-13 (2017)
Abstract Background Although anthrax immune globulin (AIG) improved survival in antibiotic-treated Bacillus anthracis-challenged animal models, whether it adds to the benefit of conventional hemodynamic support for B. anthracis toxin-associated shock
Externí odkaz:
https://doaj.org/article/fc1405e36eec411aac3a8e7cf8c16967
Akademický článek
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Publikováno v:
Cells, Vol 10, Iss 5, p 1101 (2021)
Inhibition of the RAF-MEK1/2-ERK signaling pathway is an ideal strategy for treating cancers with NRAS or BRAF mutations. However, the development of resistance due to incomplete inhibition of the pathway and activation of compensatory cell prolifera
Externí odkaz:
https://doaj.org/article/60d7606b37474f448c7f775478089539