Výsledky vyhledávání - "Letícia Martins, Mota"

Akademický článek

LC-MS characterization of valsartan degradation products and comparison with LC-PDA

Autor: Sumaia Araújo Pires, Letícia Martins Mota, Jerusa Simone Garcia, Phellipe Honorio Amaral, Eduardo César Meurer, Marcos Nogueira Eberlin, Marcello Garcia Trevisan

Publikováno v: Brazilian Journal of Pharmaceutical Sciences, Vol 51, Iss 4, Pp 839-845 (2015)

abstract Valsartan was submitted to forced degradation under acid hydrolysis condition as prescribed by the ICH. Degraded sample aliquots were separated via HPLC using a Hypersil ODS (C18) column (250 x 4.6 mm i.d., 5 µm). Either photodiode array (P

Externí odkaz: https://doaj.org/article/1f5ae62e8d2b469a85f073e813569b32

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Cell Free Remodeling of Glycosylation of Antibodies

Autor: Michael Butler, Letícia Martins Mota, Venkata S. Tayi

Publikováno v: Glycosylation ISBN: 9781071616840

The N-glycosylation profile of a monoclonal antibody (mAb) is a critical quality attribute in relation to its therapeutic application. The control of this profile during biomanufacture is difficult because of the multiple parameters that affect the g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd989d3643ffa9636c8198b3e3d6cc18
https://doi.org/10.1007/978-1-0716-1685-7_6

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Cell Free Remodeling of Glycosylation of Antibodies

Autor: Letícia Martins, Mota, Venkata S, Tayi, Michael, Butler

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2370

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eb5c231a34c02d879fab4b1f5a759094
https://pubmed.ncbi.nlm.nih.gov/34611867

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The role of protein hydrolysates in prolonging viability and enhancing antibody production of CHO cells

Autor: Ismael Obaidi, Letícia Martins Mota, Michael Butler, Andrew Quigley

Publikováno v: Applied microbiology and biotechnology. 105(8)

Four independent mAb-producing CHO cell lines were grown in media supplemented with one of seven protein hydrolysates of animal and plant origin. This generated a 7x4 matrix of replicate cultures which was analysed for viable cell density and mAb pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56907ab1627d210b68efc93988af8122
https://pubmed.ncbi.nlm.nih.gov/33796891

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Mammalian cell culture for production of recombinant proteins: A review of the critical steps in their biomanufacturing

Autor: Adam Bergin, Ismael Obaidi, Roisin O'Flaherty, Evangelia Flampouri, Michael Butler, Yongjing Xie, Letícia Martins Mota, Andrew Quigley

The manufacturing of recombinant protein is traditionally undertaken in mammalian cell culture. Today, speed, cost and safety are the primary considerations for process improvements in both upstream and downstream manufacturing. Leaders in the biopha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204b3a50e8e4f0424dc9f9e2499ccc78
https://mural.maynoothuniversity.ie/16172/

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High-throughput and high-sensitivity N-Glycan profiling: A platform for biopharmaceutical development and disease biomarker discovery

Autor: Roisin O'Flaherty, Bethan Morgan, Aled Jones, Letícia Martins Mota, Adam Bergin, Michael Butler, Yongjing Xie

Publikováno v: Analytical Biochemistry. 623:114205

Protein glycosylation contributes to critical biological function of glycoproteins. Glycan analysis is essential for the production of biopharmaceuticals as well as for the identification of disease biomarkers. However, glycans are highly heterogeneo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857329d1db311f74cbbd506ccf13ad15
https://doi.org/10.1016/j.ab.2021.114205

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LC-MS characterization of valsartan degradation products and comparison with LC-PDA

Autor: Phellipe Honorio Amaral, Marcos N. Eberlin, Sumaia Araújo Pires, Marcello G. Trevisan, Jerusa S. Garcia, Eduardo C. Meurer, Letícia Martins Mota

Publikováno v: Brazilian Journal of Pharmaceutical Sciences, Volume: 51, Issue: 4, Pages: 839-845, Published: DEC 2015
Brazilian Journal of Pharmaceutical Sciences, Vol 51, Iss 4, Pp 839-845 (2015)
Brazilian Journal of Pharmaceutical Sciences; Vol. 51 No. 4 (2015); 839-845
Brazilian Journal of Pharmaceutical Sciences; Vol. 51 Núm. 4 (2015); 839-845
Brazilian Journal of Pharmaceutical Sciences; v. 51 n. 4 (2015); 839-845
Brazilian Journal of Pharmaceutical Sciences
Universidade de São Paulo (USP)
instacron:USP

Valsartan was submitted to forced degradation under acid hydrolysis condition as prescribed by the ICH. Degraded sample aliquots were separated via HPLC using a Hypersil ODS (C18) column (250 x 4.6 mm i.d., 5 µm). Either photodiode array (PDA) detec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::293330a536cf270da9b462ea3199ec44
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000400839&lng=en&tlng=en

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