A kinetic study of the main guaco metabolites using syrup formulation and the identification of an alternative route of coumarin metabolism in humans.

Autor: João Cleverson Gasparetto, Rosângela Gonçalves Peccinini, Thais Martins Guimarães de Francisco, Letícia Bonâncio Cerqueira, Francinete Ramos Campos, Roberto Pontarolo

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0118922 (2015)

For decades guaco species have been empirically used for the treatment of respiratory diseases. However, studies have shown that the toxic and therapeutic effects of the main guaco metabolites are dose-dependent, and none clinical study was done to e

Externí odkaz: https://doaj.org/article/7e8221d68bb140fabe518f868b65464b

New Metabolites of Coumarin Detected in Human Urine Using Ultra Performance Liquid Chromatography/Quadrupole-Time-of-Flight Tandem Mass Spectrometry

Autor: Letícia Paula Leonart, João Cleverson Gasparetto, Flávia Lada Degaut Pontes, Letícia Bonancio Cerqueira, Thais Martins Guimarães de Francisco, Roberto Pontarolo

Publikováno v: Molecules, Vol 22, Iss 11, p 2031 (2017)

Coumarin (1,2-benzopyrone) is a natural compound whose metabolism in humans was established in the 1970s. However, a new metabolite was recently identified in human plasma, indicating that the metabolism of coumarin has not been completely elucidated

Externí odkaz: https://doaj.org/article/1d4ece56527443d9896e8aef5b6e827f

Stability Indicating Method for Determination of Benznidazole and Its Degradation Products in Active Pharmaceutical Ingredient

Autor: Michel Leandro Campos, Roberto Pontarolo, Iara J. Messias Reason, Letícia Bonancio Cerqueira, Mariana Millan Fachi, Wilton H. Kawaguchi, Angela C. L. B. Trindade, Alan G. Gonçalves

Publikováno v: Journal of the Brazilian Chemical Society v.31 n.6 2020
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ
Journal of the Brazilian Chemical Society, Volume: 31, Issue: 6, Pages: 1194-1202, Published: 08 JUN 2020

Currently, treatment of Chagas disease is restricted to the use of benznidazole and nifurtimox; however, nifurtimox was temporarily suspended in some countries. Based on the limitations in pharmacological treatments, it is essential to guarantee the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26797f0b40d5ece00025127d1f28cffb
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532020000601194

Neuroprotective Effect of Caryocar brasiliense Camb. Leaves Is Associated with Anticholinesterase and Antioxidant Properties

Autor: Francinete Ramos Campos, Elson Alves Costa, Paulo César Ghedini, Hiasmin Franciely da Silva Neri, Eric de Souza Gil, Luane Ferreira Garcia, Douglas Vieira Thomaz, Fernanda C. A. Santos, Letícia Bonancio Cerqueira, Thiago Sardinha de Oliveira, Henric Pietro Vicente Gil, Roberto Pontarolo

Publikováno v: Oxidative Medicine and Cellular Longevity
BASE-Bielefeld Academic Search Engine
Oxidative Medicine and Cellular Longevity, Vol 2018 (2018)

Pequi (Caryocar brasiliense) is an endemic species from Brazilian Cerrado, and their fruits are widely used in regional cuisine. In this work, a crude hydroalcoholic extract (CHE) of C. brasiliense leaves and its resulting fractions in hexane (HF), c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a883add68c189f82301916cad4ad108f
http://europepmc.org/articles/PMC6215548

Rapid detection of aspergillosis in immunocompromised patients using DIMS and chemometric analysis

Autor: João Cleverson Gasparetto, Francinete Ramos Campos, Mário S. Piantavini, Isabela F. Zaramella, Letícia Bonancio Cerqueira, Roberto Pontarolo, Thais Martins Guimarães de Francisco

Publikováno v: Analytical Methods. 7:6346-6351

Rapid diagnosis of aspergillosis is one of the most important aspects for disease control and treatment. The purpose of this study was to develop a metabolic fingerprint of serum from immunocompromised patients that can enable rapid detection of aspe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f269f11621b55540a4a0c48c9a9810ce
https://doi.org/10.1039/c5ay01146a