Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Leszek Ignatowicz"'
Autor:
Anna Cebula, Michal Kuczma, Edyta Szurek, Maciej Pietrzak, Natasha Savage, Wessam R. Elhefnawy, Grzegorz Rempala, Piotr Kraj, Leszek Ignatowicz
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Autoreactive T cells are normally eliminated during their maturation in the thymus, but an unknown number of autoreactive CD4+ T cells escape to the periphery. Here the authors show, by comparing the T cell receptors of mice sufficient or deficient i
Externí odkaz:
https://doaj.org/article/f0ecadad87d6496c8f838eae6f2b9404
Autor:
Lauren M. Browning, Caroline Miller, Michal Kuczma, Maciej Pietrzak, Yu Jing, Grzegorz Rempala, Pawel Muranski, Leszek Ignatowicz, Piotr Kraj
Publikováno v:
Cell Reports, Vol 33, Iss 1, Pp 108219- (2020)
Summary: Bone morphogenic proteins (BMPs) are members of the transforming growth factor β (TGF-β) cytokine family promoting differentiation, homeostasis, and self-renewal of multiple tissues. We show that signaling through the bone morphogenic prot
Externí odkaz:
https://doaj.org/article/667fc846294b4f0a8093f179d49af5a6
Autor:
Lukasz Wojciech, Edyta Szurek, Michal Kuczma, Anna Cebula, Wessam R. Elhefnawy, Maciej Pietrzak, Grzegorz Rempala, Leszek Ignatowicz
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract In the gut, various subsets of intraepithelial T cells (IELs) respond to self or non-self-antigens derived from the body, diet, commensal and pathogenic microbiota. Dominant subset of IELs in the small intestine are TCRαβCD8αα+ cells, wh
Externí odkaz:
https://doaj.org/article/17fae1688ad846f5801bedc8c82b0475
Autor:
Edyta Szurek, Anna Cebula, Lukasz Wojciech, Maciej Pietrzak, Grzegorz Rempala, Pawel Kisielow, Leszek Ignatowicz
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141161 (2015)
Helios transcription factor and semaphorin receptor Nrp-1 were originally described as constitutively expressed at high levels on CD4+Foxp3+ T regulatory cells of intrathymic origin (tTregs). On the other hand, CD4+Foxp3+ Tregs generated in the perip
Externí odkaz:
https://doaj.org/article/994a36e571b541ec8e496972d802fd2e
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47729 (2012)
We have investigated the gross, microscopic and molecular effects of carnitine deficiency in the neonatal gut using a mouse model with a loss-of-function mutation in the OCTN2 (SLC22A5) carnitine transporter. The tissue carnitine content of neonatal
Externí odkaz:
https://doaj.org/article/982cf7ca664f4c799590649863b0ec17
Autor:
Piotr Kraj, Vu L. Ngo, Maciej Pietrzak, Michal Kuczma, Timothy L. Denning, Leszek Ignatowicz, Edyta Szurek, Anna Cebula
Publikováno v:
Mucosal Immunology. 14:443-454
The physiological role of T cell anergy induction as a key mechanism supporting self-tolerance remains undefined, and natural antigens that induce anergy are largely unknown. In this report, we used TCR sequencing to show that the recruitment of CD4+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d88a47f1d6ca4b21cfe8ba56d395f772
https://doi.org/10.1038/s41385-020-00349-4
https://doi.org/10.1038/s41385-020-00349-4
Autor:
Edyta Szurek, Andrew T. Gewirtz, Asma Nusrat, Oscar Medina-Contreras, Nora Moore, Vu L. Ngo, Michal Kuczma, Leszek Ignatowicz, Hirohito Abo, Timothy L. Denning, Didier Merlin
Publikováno v:
Proc Natl Acad Sci U S A
Enteropathogenic bacterial infections are a global health issue associated with high mortality, particularly in developing countries. Efficient host protection against enteropathogenic bacterial infection is characterized by coordinated responses bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4f9b340e36bf3cc6ff04728f43e30d1
https://doi.org/10.1073/pnas.2004484117
https://doi.org/10.1073/pnas.2004484117
Autor:
Edyta Szurek, Michal Kuczma, Maciej Pietrzak, Piotr Kraj, Wessam Elhefnawy, Leszek Ignatowicz, Natasha M. Savage, Grzegorz A. Rempala, Anna Cebula
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Thymic central tolerance eliminates most immature T cells with autoreactive T cell receptors (TCR) that recognize self MHC/peptide complexes. Regardless, an unknown number of autoreactive CD4+Foxp3− T cells escape negative selection and in the peri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b9d7d02918154ee2073d14bed22a79a
http://link.springer.com/article/10.1038/s41467-019-12820-3
http://link.springer.com/article/10.1038/s41467-019-12820-3
Autor:
Grzegorz A. Rempala, Anna Cebula, Edyta Szurek, Leszek Ignatowicz, Michal Kuczma, Maciej Pietrzak, Wessam Elhefnawy, Lukasz Wojciech
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports
Scientific Reports
In the gut, various subsets of intraepithelial T cells (IELs) respond to self or non-self-antigens derived from the body, diet, commensal and pathogenic microbiota. Dominant subset of IELs in the small intestine are TCRαβCD8αα+ cells, which are d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef113e9ac59f572b0a0af0e481cd77f
https://doaj.org/article/17fae1688ad846f5801bedc8c82b0475
https://doaj.org/article/17fae1688ad846f5801bedc8c82b0475
Autor:
Lauren M, Browning, Caroline, Miller, Michal, Kuczma, Maciej, Pietrzak, Yu, Jing, Grzegorz, Rempala, Pawel, Muranski, Leszek, Ignatowicz, Piotr, Kraj
Publikováno v:
Cell Rep
Bone morphogenic proteins (BMPs) are members of the transforming growth factor β (TGF-β) cytokine family promoting differentiation, homeostasis, and self-renewal of multiple tissues. We show that signaling through the bone morphogenic protein recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f783c69f62c09443b7fa1b079204c080
https://pubmed.ncbi.nlm.nih.gov/33027660
https://pubmed.ncbi.nlm.nih.gov/33027660